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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j3370-vancomycin-500mg-injection
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    HCPCS Level II J3370: Vancomycin HCl Injection, 500 mg

    HCPCS Level II code J3370 describes a 500 mg injection of vancomycin HCl, a parenteral antibiotic preparation typically administered as an intravenous infusion or injection in hospital inpatient, hospital outpatient, emergency department, or infusion center settings; the code is used for billing the drug product when provided separately from the professional administration service and when documenting the specific drug and dosage for clinical and claims records.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult hospitalized for suspected or confirmed Gram-positive serious infection (for example, methicillin-resistant Staphylococcus aureus bacteremia, complicated skin and soft tissue infection, or prosthetic joint infection) requiring intravenous antibiotic therapy. The treating team (hospitalist or infectious disease physician) orders J3370 for vancomycin 500 mg. Nursing or an infusion pharmacist prepares the dose, often diluting vancomycin for intravenous infusion and administering via peripheral or central venous access in the inpatient setting, emergency department, or outpatient infusion center. Baseline and interval labs (renal function, vancomycin trough or area-under-curve monitoring) and vital sign monitoring occur per facility protocol. Documentation includes indication, dose and concentration, route, start and stop times, patient tolerance, and any adverse reactions. Typical sites of service are inpatient acute care, hospital outpatient department, emergency department, and ambulatory infusion centers.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, initial, for therapy, prophylaxis, or diagnosis; up to 1 hourUsed when vancomycin infusion is billed as an infusion service (initial hour) in outpatient or office-based infusion settings.
    96366Intravenous infusion, each additional hourUsed when the infusion extends beyond the initial hour for prolonged administration or monitoring.
    96374Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); intravenous push, single or initial substance/drugUsed when vancomycin is administered as an IV push (rare due to infusion-related reactions) and documentation supports push technique.
    36415Collection of venous blood by venipunctureUsed for lab monitoring such as vancomycin trough or renal function tests associated with therapy.
    99223Initial hospital care, typically 70 minutes or moreRepresents physician evaluation and management for hospitalized patients initiating IV vancomycin therapy; used where applicable to capture clinical management.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207RH0000XHematology (Internal Medicine) PhysicianAn internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
    163W00000XRegistered Nurse(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    261QM1300XMulti-Specialty Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    103TE1100XExercise & Sports PsychologistA psychologist with a proficiency in sports psychology that uses psychological knowledge and skills to address optimal performance and well-being of a…
    207RA0001XAdvanced Heart Failure and Transplant Cardiology PhysicianSpecialists in Advanced Heart Failure and Transplant Cardiology would participate in the inpatient and outpatient management of patients with advanced…
    320600000XIntellectual and/or Developmental Disabilities Residential Treatment FacilityA residential facility that provides habilitation services and other care and treatment to adults or children diagnosed with developmental and intelle…

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    A37.91Whooping cough, unspecified species with pneumonia
    A41.51Sepsis due to Escherichia coli [E. coli]
    A41.52Sepsis due to Pseudomonas
    A41.9Sepsis, unspecified organism
    A49.02Methicillin resistant Staphylococcus aureus infection, unspecified site
    A49.1Streptococcal infection, unspecified site
    A49.9Bacterial infection, unspecified
    A54.89Other gonococcal infections
    B95.61Methicillin susceptible Staphylococcus aureus infection as the cause of diseases classified elsewhere
    B96.21Shiga toxin-producing Escherichia coli [E. coli] [STEC] O157 as the cause of diseases classified elsewhere

    Showing 1–10 of 29

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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