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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j2505-pegfilgrastim-6mg-injection-oncology-supportive-care
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    HCPCS Level II J2505: Injection, pegfilgrastim, 6 mg

    HCPCS Level II code J2505 describes an injection of pegfilgrastim, 6 mg, a long-acting granulocyte colony-stimulating factor used to reduce the incidence of infection in patients receiving myelosuppressive chemotherapy; the service is an injectable biologic medication typically administered in an outpatient oncology clinic or infusion center as a single-dose subcutaneous injection per chemotherapy cycle.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult undergoing myelosuppressive chemotherapy for a solid tumor (for example, breast cancer or lung cancer) or a patient with a history of febrile neutropenia requiring prophylaxis. The drug administered is J2505 (pegfilgrastim, 6 mg) given as a single subcutaneous injection to stimulate neutrophil recovery. Clinical workflow: the oncology nurse confirms chemotherapy schedule and neutropenia risk, reviews recent complete blood count (CBC), verifies patient identity and weight, documents indication and informed consent, prepares J2505 per manufacturer and facility protocols, administers subcutaneously (often in the abdomen or thigh), observes the patient briefly for immediate adverse reactions, documents lot number and injection site, and schedules follow-up CBC and subsequent oncology visits. Typical sites of service include outpatient oncology infusion centers, physician offices (oncology practices), and hospital outpatient departments. Common patient scenarios include: primary prophylaxis when expected risk of febrile neutropenia is high, secondary prophylaxis after a prior neutropenic complication, or treatment of severe neutropenia with clinical justification.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96372Therapeutic, prophylactic, or diagnostic injection (e.g., subcutaneous or intramuscular); single or initial substance/drugCommonly used to report the administration service when billing the injection separately from the drug in non-drug-bundle payer scenarios.
    36415Collection of venous blood by venipuncturePerformed before or after J2505 to obtain CBC for neutrophil monitoring.
    99213Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutesUsed when an established patient is evaluated and the decision to administer J2505 is made during a standard office visit.
    96374Therapeutic, prophylactic, or diagnostic injection; each additional sequential infusion (use when applicable)May be used rarely if additional injections are given during the same encounter and payer allows stacking.
    96127Brief emotional/behavioral assessment (screening)Occasionally used for brief standardized screening if psychosocial distress is documented related to chemotherapy complications; not routine but seen in comprehensive oncology visits.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    247200000XOther TechnicianA collective term for persons with specialized training in various narrow fields of expertise whose occupations require training and skills in specifi…
    207WX0108XUveitis and Ocular Inflammatory Disease (Ophthalmology) PhysicianAn ophthalmologist who specializes in the treatment of intraocular inflammation, scleritis, keratitis and infectious disorders affecting the eye and i…
    222Z00000XOrthotistA health care professional who is specifically educated and trained to manage comprehensive orthotic patient care, including musculoskeletal and neuro…
    163WC0400XCase Management Registered NurseNursing Service Providers · Registered Nurse

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    C15.9Malignant neoplasm of esophagus, unspecified
    C18.9Malignant neoplasm of colon, unspecified
    C20Malignant neoplasm of rectum
    C25.9Malignant neoplasm of pancreas, unspecified
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C43.9Malignant melanoma of skin, unspecified
    C50.911Malignant neoplasm of unspecified site of right female breast
    C61Malignant neoplasm of prostate
    C67.9Malignant neoplasm of bladder, unspecified
    C71.9Malignant neoplasm of brain, unspecified

    Showing 1–10 of 28

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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