HCPCS J1595: Injection, Glatiramer Acetate, 20 mg

HCPCS Level II code J1595 represents a billed injectable medication product: injection, glatiramer acetate, 20 mg, typically administered as a subcutaneous injection for disease-modifying therapy; service type is medication administration and the typical site of service is outpatient clinic or physician office infusion/injection suite.

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HCPCS J1595: Injection, Glatiramer Acetate, 20 mg

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Get alerted when payer policies referencing J1595 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult diagnosed with relapsing-remitting multiple sclerosis (MS) receiving outpatient subcutaneous therapy with glatiramer acetate, 20 mg. The patient presents to an infusion or specialty pharmacy clinic for medication administration or to a neurology clinic for training on self-injection. The clinical workflow includes verification of the prescription for J1595, pre-administration screening for allergies and infection, assessment of recent relapses and baseline vital signs, patient education on injection technique and adverse effects (for example, injection-site reactions, transient chest tightness or flushing), preparation and administration of the 20 mg glatiramer acetate dose via subcutaneous injection, documentation of lot number and expiration, and post-injection observation for immediate reactions. Billing for the medication uses J1595 and may be accompanied by appropriate visit or injection administration CPT codes, device or supply charges, and modifiers to indicate special circumstances (for example, patient status or service component). Typical sites of service include outpatient infusion/administration clinics, neurology offices, specialty pharmacy clinics, and the patient’s home when administered by a qualified clinician or under a home health plan arrangement.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Commonly used to report the professional service of administering a subcutaneous injection of glatiramer acetate when billed separately from the drug supply.
`90471`	Immunization administration (includes percutaneous, intranasal, or oral) — first or only component	Occasionally used by payers for counseling and administration-type services; less typical for prescription biologic injectables but included where administration codes are required.
`96401`	Chemotherapy administration, subcutaneous or intramuscular; non-hormonal antineoplastic	Not routinely used for glatiramer acetate; listed for clinical workflow distinction when oncology-style infusion billing rules are present (use payer guidance).
`99001`	Handling and/or processing of a single dose injectable medication by a pharmacy or licensed practitioner (facility-specific)	Used in some facility billing scenarios for preparation/handling of specialty injectable medications.
`G0498`	Administration of a medication through a subcutaneous infusion pump or catheter; per 30-day supply (Medicare-specific)	Relevant only if the medication is delivered via an approved pump/catheter system — generally not applicable to standard self-injection but included for completeness.
`S4993`	Injectable drug administration, subcutaneous or intramuscular (payer-specific HCPCS-level)	Payer-specific codes sometimes appear alongside `J` drug codes for administration reporting; check payer policies for appropriate use.

Related Modifiers

5 rows

Modifier	Description	When to Use
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
2084P0800X	Psychiatry Physician	A Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
367A00000X	Advanced Practice Midwife	Advanced practice midwifery encompasses the independent provision of care during pregnancy, childbirth, and the postpartum period; sexual and reproduc…
3336C0002X	Clinic Pharmacy	A pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
2278E1000X	Educational Certified Respiratory Therapist	The focus of patient and family education activities is to promote knowledge of disease process, medical therapy, and self help. Respiratory therapis…
313M00000X	Nursing Facility/Intermediate Care Facility	An institution (or a distinct part of an institution) which- (1) is primarily engaged in providing to residents- (A) skilled nursing care and related …
405300000X	Prevention Professional	Prevention Professionals work in programs aimed to address specific patient needs, such as suicide prevention, violence prevention, alcohol avoidance,…
208C00000X	Colon & Rectal Surgery Physician	A colon and rectal surgeon is trained to diagnose and treat various diseases of the intestinal tract, colon, rectum, anal canal and perianal area by m…
207YS0123X	Facial Plastic Surgery Physician	An otolaryngologist who specializes in facial plastic surgery.

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Commonly used to report the professional service of administering a subcutaneous injection of glatiramer acetate when billed separately from the drug supply.
`90471`	Immunization administration (includes percutaneous, intranasal, or oral) — first or only component	Occasionally used by payers for counseling and administration-type services; less typical for prescription biologic injectables but included where administration codes are required.
`96401`	Chemotherapy administration, subcutaneous or intramuscular; non-hormonal antineoplastic	Not routinely used for glatiramer acetate; listed for clinical workflow distinction when oncology-style infusion billing rules are present (use payer guidance).
`99001`	Handling and/or processing of a single dose injectable medication by a pharmacy or licensed practitioner (facility-specific)	Used in some facility billing scenarios for preparation/handling of specialty injectable medications.
`G0498`	Administration of a medication through a subcutaneous infusion pump or catheter; per 30-day supply (Medicare-specific)	Relevant only if the medication is delivered via an approved pump/catheter system — generally not applicable to standard self-injection but included for completeness.
`S4993`	Injectable drug administration, subcutaneous or intramuscular (payer-specific HCPCS-level)	Payer-specific codes sometimes appear alongside `J` drug codes for administration reporting; check payer policies for appropriate use.

Related Modifiers

5 rows

Modifier	Description	When to Use
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
2084P0800X	Psychiatry Physician	A Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
367A00000X	Advanced Practice Midwife	Advanced practice midwifery encompasses the independent provision of care during pregnancy, childbirth, and the postpartum period; sexual and reproduc…
3336C0002X	Clinic Pharmacy	A pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
2278E1000X	Educational Certified Respiratory Therapist	The focus of patient and family education activities is to promote knowledge of disease process, medical therapy, and self help. Respiratory therapis…
313M00000X	Nursing Facility/Intermediate Care Facility	An institution (or a distinct part of an institution) which- (1) is primarily engaged in providing to residents- (A) skilled nursing care and related …
405300000X	Prevention Professional	Prevention Professionals work in programs aimed to address specific patient needs, such as suicide prevention, violence prevention, alcohol avoidance,…
208C00000X	Colon & Rectal Surgery Physician	A colon and rectal surgeon is trained to diagnose and treat various diseases of the intestinal tract, colon, rectum, anal canal and perianal area by m…
207YS0123X	Facial Plastic Surgery Physician	An otolaryngologist who specializes in facial plastic surgery.

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS J1595: Injection, Glatiramer Acetate, 20 mg

Sign up for hcpcs J1595 policy alerts

HCPCS J1595: Injection, Glatiramer Acetate, 20 mg

Sign up for hcpcs J1595 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does HCPCS code J1595 represent and where is it typically used?

Which CPT or other administration codes are commonly billed alongside J1595?

What clinical workflow and documentation steps are associated with administering J1595?

Which modifiers might be appropriate when billing J1595 and when are they used?

What ICD-10 diagnosis codes are typically used with J1595?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does HCPCS code J1595 represent and where is it typically used?

Which CPT or other administration codes are commonly billed alongside J1595?

What clinical workflow and documentation steps are associated with administering J1595?

Which modifiers might be appropriate when billing J1595 and when are they used?

What ICD-10 diagnosis codes are typically used with J1595?

References