HCPCS Level II J2150: Injection, Mannitol 25% in 50 mL - OpenPayer

Summary & Overview

HCPCS Level II J2150: Injection, Mannitol 25% in 50 mL

HCPCS Level II code J2150 denotes the injectable medication mannitol, 25% in a 50 mL presentation. Mannitol is an osmotic diuretic commonly used in acute care to reduce elevated intracranial pressure and to induce osmotic diuresis in select clinical scenarios. Nationally, accurate coding for parenteral agents like mannitol supports appropriate reimbursement, care coordination in acute settings, and medication utilization tracking.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. The publication outlines payer coverage considerations, typical billing practices, and clinical context for use of this injectable formulation.

Readers will learn: the clinical role and administration setting for J2150, common billing and claim considerations relevant to hospital and emergency department service lines, and the types of benchmarks and policy updates that affect coverage and payment for injectable hyperosmotic agents. Data not available in the input is indicated where applicable.

AetnaBlue Cross Blue ShieldCigna HealthUnitedHealthcareMedicareJ2150HCPCS Level IImannitol injectionintravenous medicationacute carehospital servicesemergency medicinepharmacy billinginjectable therapy

Billing Code Overview

HCPCS Level II code J2150 describes an injection of mannitol, 25% in 50 mL. This code represents a single-dose parenteral administration of a hyperosmotic diuretic solution used to reduce intracranial pressure, promote osmotic diuresis, or manage specific acute fluid and electrolyte indications.

Service type: Intravenous medication administration (single-dose injectable therapy)
Typical site of service: Hospital inpatient and emergency department settings, and other acute care units where intravenous osmotic therapy is indicated

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult admitted to the emergency department or hospital with acute cerebral edema or elevated intracranial pressure after traumatic brain injury, intracerebral hemorrhage, or cranial surgery. The clinician orders hyperosmolar therapy with J2150 (injection, mannitol, 25% in 50 ml) to reduce intracranial pressure and promote diuresis. The medication is prepared by pharmacy or an authorized clinician, IV access is confirmed (preferably a large-bore peripheral or central venous line), and mannitol is administered as an intravenous bolus over the recommended time with concurrent monitoring of neurologic status, serum osmolality, electrolytes, and urine output. Typical workflow steps: assess indication and contraindications, verify orders and medication availability, obtain baseline vitals and labs (serum sodium, osmolality, renal function), ensure adequate IV access, administer J2150 per protocol, monitor patient for hemodynamic changes and neurologic response, repeat laboratory checks and documentation, and consider additional doses or alternative therapies based on response.

Coding Specifications

Modifier	Description	When to Use
`11`	Continued treatment by same physician	Use when a subsequent visit or service is submitted by the same physician for ongoing management related to the mannitol administration.

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Taxonomy Code	Specialty	Notes
2084P0800X	Emergency Medicine	Emergency physicians commonly order and oversee IV mannitol for acute intracranial hypertension.
208D00000X	Neurological Surgery	Neurosurgeons administer mannitol intraoperatively and for perioperative intracranial pressure control.
207R00000X	Internal Medicine (Hospitalist)	Hospitalists manage inpatient administration and monitoring of hyperosmolar therapy.
364S00000X	Critical Care Medicine	Intensivists manage mannitol use in the ICU with advanced hemodynamic and neurologic monitoring.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`G93.6`	Cerebral edema	Primary indication for mannitol to reduce intracranial pressure.
`S06.5X0A`	Traumatic subdural hemorrhage without loss of consciousness, initial encounter	Intracranial hemorrhage cases often require osmotherapy with mannitol.
`I61.9`	Intracerebral hemorrhage, unspecified	Hemorrhagic stroke with elevated intracranial pressure treated with mannitol.
`I62.9`	Nontraumatic intracranial hemorrhage, unspecified	Nontraumatic bleeding causing increased intracranial pressure.
`T79.4XXA`	Traumatic compartment syndrome of other sites, initial encounter	Included when mannitol is used for severe edema in compartment syndromes or as osmotic diuresis in selected situations.
`G91.1`	Communicating hydrocephalus	Elevated intracranial pressure from hydrocephalus may prompt temporary osmotic therapy.
`G92`	Toxic encephalopathy	Cerebral edema from toxic/metabolic causes may be managed with osmotic agents including mannitol.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	May be used for non-IV injections; not typically used for IV mannitol but listed here for contrast with injection coding pathways.
`36415`	Collection of venous blood by venipuncture	Performed before or after administration to obtain serum electrolytes, osmolality, and renal function tests.
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	Used when mannitol is administered as an IV infusion over time rather than a bolus.
`94002`	Ventilation assist and management, initiation of pressure support ventilation (for initial day)	May be relevant when mannitol administration is performed in mechanically ventilated patients requiring sedation and ventilator management.
`99183`	Physician attendance and supervision for moderate sedation provided by an anesthesiologist; per 15 minutes	Used when moderate sedation is required for safe administration and requires physician supervision.

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