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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j0878-daptomycin-injection-1mg
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    HCPCS Level II J0878: Injection, daptomycin, 1 mg

    HCPCS Level II code J0878 describes the drug administration unit for daptomycin quantified as 1 mg and is used on medical billing records when this intravenous antibiotic is supplied for treatment of serious gram-positive infections; the service type is injection (intravenous or intramuscular) drug administration and the typical site of service is hospital inpatient, hospital outpatient infusion center, or outpatient infusion clinic.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only).

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult admitted to an inpatient ward or seen in an outpatient infusion center with a serious gram-positive bacterial infection requiring intravenous daptomycin therapy. For example, a 68-year-old male with a prosthetic joint infection and persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia after initial therapy may be started on daptomycin. The clinical workflow includes order entry by the attending infectious disease physician, pharmacy verification of dosing (commonly weight-based, e.g., 6 mg/kg daily), preparation of the appropriate daptomycin vial(s) by the pharmacy, administration via peripheral or central intravenous line by a registered nurse, monitoring of creatine phosphokinase (CPK) and renal function prior to and during therapy, and documentation of dose, lot number, units billed, and site of service. Billing uses J0878 reported per milligram (1 mg units) with quantity reflecting total milligrams administered for the encounter. Typical sites of service include the inpatient hospital floor, observation unit, outpatient infusion center, emergency department when administered as part of a visit, or skilled nursing facility when provided as part of parenteral antibiotic therapy.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hourOften billed for the initial administration time of an IV daptomycin infusion when infusion duration is ≤1 hour and infusion services are separately reportable.
    96366Intravenous infusion, each additional hour (List separately in addition to code for primary infusion)Billed when the infusion extends beyond the initial hour and infusion time is reportable.
    96368Intravenous infusion, concurrent infusionUsed if multiple infusions are given concurrently and payer allows separate reporting.
    96374Therapeutic, prophylactic, or diagnostic injection (intravenous push), each additional drug/biologicMay be used for IV push administration if daptomycin is administered as a bolus per institutional protocol and payer policy allows.
    36415Collection of venous blood by venipuncturePerformed for baseline and follow-up labs such as CPK and renal function monitoring related to daptomycin therapy.
    99070Supplies and materials (e.g., saline flushes, tubing) used during infusionBilled to capture non-covered supplies associated with infusion if payer policy permits.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    27Modifier 27 indicates a separate, subsequent outpatient hospital E/M service provided to the same patient on the same date by a different provider in a hospital outpatient setting. It is a…- Use modifier -27 on facility (hospital outpatient/ambulatory service center) claims to report a subsequent, separate, and distinct outpatient E/M service provided to the same patient on the same…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    209800000XLegal Medicine (M.D./D.O.) PhysicianLegal Medicine is a special field of medicine that focuses on various aspects of medicine and law. Historically, the practice of legal medicine made c…
    133VN1501XSports Dietetics Nutrition Registered DietitianAn individual who is a Board Certified Specialist in Sports Dietetics and applies evidence-based nutrition knowledge in exercise and sports. RDNs spec…
    163WP0200XPediatric Registered NurseNursing Service Providers · Registered Nurse
    333600000XPharmacyA facility used by pharmacists for the compounding and dispensing of medicinal preparations and other associated professional and administrative servi…
    364SA2100XAcute Care Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    237700000XHearing Instrument SpecialistIndividuals who test hearing for the selection, adaptation, fitting, adjusting, servicing, and sale of hearing aids. Hearing Instrument Specialist is …

    Related ICD-10-CM Codes

    18 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    A49.1Streptococcal infection, unspecified site
    A49.2Hemophilus influenzae infection, unspecified site
    A49.9Bacterial infection, unspecified
    B37.7Candidal sepsis
    B95.61Methicillin susceptible Staphylococcus aureus infection as the cause of diseases classified elsewhere
    B95.62Methicillin resistant Staphylococcus aureus infection as the cause of diseases classified elsewhere
    I33.0Acute and subacute infective endocarditis
    J15.211Pneumonia due to Methicillin susceptible Staphylococcus aureus
    J15.3Pneumonia due to streptococcus, group B

    Showing 1–10 of 18

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Chimeric Antigen Receptor (CAR) T-Cell TherapyColorado Rocky Mountain Health Plans2026-08-01
    Allogeneic Hematopoietic Progenitor Cell TherapyAmbetter Georgia2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)UnitedHealthcare2026-08-01
    Reblozyl (luspatercept-aamt) Medical Benefit Drug PolicyUnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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