J0380 Metaraminol Injection HCPCS Reimbursement | OpenPayer

Summary & Overview

HCPCS J0380: Metaraminol Injection, per 10 mg

HCPCS Level II code J0380 denotes an injection of metaraminol bitartrate, billed per 10 mg. Metaraminol is a vasopressor used to raise systemic blood pressure in acute hypotensive events, making this code relevant for hospitals, emergency departments, and other acute care settings nationwide. Accurate coding of vasoactive medication administration supports clinical documentation, care coordination, and claims processing for time-sensitive interventions.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. The publication provides a concise overview of how J0380 is used, typical sites of service, and common billing considerations tied to inpatient and emergency care delivery. Where available, readers will find benchmarking context and policy highlights that affect reimbursement and coding practice for injectable vasoactive agents.

Readers will learn: the clinical context for using metaraminol, how the HCPCS Level II code maps to acute care medication administration, and which national payers commonly cover services billed with J0380. The piece also identifies gaps where supplemental billing details (such as specific modifiers, taxonomies, or diagnosis mappings) are not available in the input. This national-level summary is intended to inform coding, revenue cycle, and clinical teams about the role of J0380 in acute-care medication billing.

AetnaBlue Cross Blue ShieldCigna HealthUnitedHealthcareMedicareJ0380HCPCS Level IImetaraminolvasopressorinjectionacute carehospital billingemergency departmentmedication administration

Billing Code Overview

HCPCS Level II code J0380 represents an injection of metaraminol bitartrate, billed per 10 mg. This code is used to report the administration of metaraminol, a vasopressor agent typically given to support blood pressure in acute care settings.

Service Type: Injection / Medication administration

Typical Site of Service: Hospital inpatient, emergency department, or other acute care settings where intravenous vasoactive medications are administered

Data not available in the input.

Clinical & Coding Specifications

Clinical Context

A 68-year-old male with symptomatic orthostatic hypotension and acute hypotensive episodes in the emergency department receives a bolus of vasopressor medication. The clinician orders an intravenous injection of metaraminol bitartrate to rapidly raise arterial blood pressure while evaluating for underlying causes such as volume depletion or medication effects. The procedure is performed in an acute care setting (emergency department, hospital ward, or inpatient critical care unit). The workflow includes assessment of vital signs and IV access, review of allergies and medication interactions, preparation of the J0380 unit dose (per 10 mg), administration by an authorized clinician (physician, emergency medicine nurse under protocol, or critical care nurse) with continuous hemodynamic monitoring, documentation of dose, time, route, response, and any adverse effects, and reconciliation with facility medication administration records and billing documentation for J0380 units administered.

Coding Specifications

Modifier	Description	When to Use
`22`	Increased procedural services	Use when additional work or complexity beyond typical administration (e.g., difficult IV access requiring substantially more time) justifies increased payment.

HCPCS J7345: Aminolevulinic Acid HCl 10% Topical Gel, 10 mg

HCPCS-J2327-RISANKIZUMAB-INTRAVENOUS-1MG

HCPCS Level II J2327: Intravenous Injection of Risankizumab-rzaa, 1 mg

HCPCS-J0638-CANAKINUMAB-INJECTION-1MG

HCPCS Level II J0638: Canakinumab Injection, 1 mg

HCPCS-J2260-MILRINONE-LACTATE-INJECTION-5MG

HCPCS J2260: Injection, Milrinone Lactate, 5 mg

HCPCS-J3030-SUMATRIPTAN-INJECTION-6MG-OFFICE-ADMINISTRATION

HCPCS Level II J3030: Sumatriptan Succinate Injection, 6 mg

HCPCS-J8610-METHOTREXATE-ORAL-2-5-MG

HCPCS Level II J8610: Methotrexate, Oral, 2.5 mg

HCPCS-J1010-METHYLPREDNISOLONE-ACETATE-INJECTION-1MG

HCPCS J1010: Injection of Methylprednisolone Acetate, 1 mg

HCPCS-J2020-LINEZOLID-200MG-INJECTION

HCPCS J2020: Injection, Linezolid 200 mg

HCPCS-J7620-ALBUTEROL-IPRATROPIUM-NEBULIZED-DME

HCPCS J7620: Albuterol and Ipratropium Nebulized, DME Administration

HCPCS-J0875-DALBAVANCIN-INJECTION-5MG

HCPCS Level II J0875: Dalbavancin Injection, 5 mg

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Taxonomy Code	Specialty	Notes
`207P00000X`	Emergency Medicine	Common setting for acute IV vasopressor administration for hypotension or shock.
`208000000X`	Internal Medicine	Hospitalists and internists commonly manage hypotension and order IV vasopressors.
`207R00000X`	Anesthesiology	Anesthesiologists administer and manage vasopressors perioperatively and in critical care.
`246Z00000X`	Critical Care Medicine	Intensivists manage continuous vasopressor therapy and acute hemodynamic instability.
`163W00000X`	Nurse Anesthetist / Advanced Practice Nurse	Advanced practice nurses and CRNAs may administer under protocol and manage titration.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`I95.1`	Orthostatic hypotension	Common indication for acute symptomatic hypotension treated with vasopressors.
`I95.9`	Hypotension, unspecified	General code for low blood pressure prompting vasopressor administration when etiology is undifferentiated.
`I46.9`	Cardiac arrest, cause unspecified	Vasopressors such as metaraminol may be used during resuscitation efforts.
`R57.9`	Shock, unspecified	Vasopressors are commonly used to support blood pressure in shock states.
`E86.0`	Dehydration	Volume depletion leading to hypotension where vasopressor support may be required.
`T50.995A`	Poisoning by other unspecified drugs, initial encounter	Drug-induced hypotension may necessitate vasopressor administration.
`I10`	Essential (primary) hypertension	Included as comorbidity; treatment decisions for hypotension consider baseline hypertensive history.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	May be used if metaraminol is administered via IM/SC route in outpatient settings, though IV administration is more typical.
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	Used when metaraminol is given as a continuous IV infusion rather than a single bolus; documents initial infusion management.
`96366`	Intravenous infusion; each additional hour	Used for subsequent hours of continuous infusion management of vasopressor therapy.
`92950`	Cardiopulmonary resuscitation (CPR), in hospital or emergency department; manual	May be billed in conjunction when metaraminol is administered during resuscitation efforts.
`36415`	Collection of venous blood by venipuncture	Often performed for laboratory evaluation related to hypotension management and prior to vasopressor therapy.

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