HCPCS Level II code G0480 describes a definitive drug test performed per day for 1–7 drug classes, using instrumental methods that identify individual drugs and distinguish structural isomers (for example, GC/MS or LC/MS), with stable isotope or similar internal standards and method-specific calibration and matrix-matched quality control; this service includes specimen validity testing and can be reported for qualitative or quantitative testing, typically performed in clinical laboratories or specialized toxicology laboratories and billed as a laboratory/diagnostic service.

For related coverage guidance, see recent payer policy updates: Esophagogastroduodenoscopy (EGD) Coverage Policy, Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD), Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant Testing.