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    v1.0.30
    OpenPayerBilling CodesProcedures / Professional ServicesHCPCS hcpcs-g0010-hepatitis-b-vaccine-administration
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    HCPCS G0010: Administration of Hepatitis B Vaccine

    HCPCS Level II code G0010 describes the administration of the hepatitis B vaccine, a preventive immunization service typically delivered as an injection in an outpatient clinic, physician office, community health center, or public health setting; the code documents the act of vaccine administration rather than the vaccine product itself and is used for billing and encounter reporting for hepatitis B vaccination services.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Clinical & Coding Specifications

    Clinical Context

    A patient presents to a primary care clinic or public health vaccination site for hepatitis B immunization. Typical patients include adults at routine risk (e.g., unvaccinated healthcare workers, individuals with chronic liver disease, people with diabetes under age 60, travelers to endemic areas) and infants/children per the childhood immunization schedule. The clinical workflow: registration and verification of immunization history and insurance; review of contraindications (severe allergic reaction to prior dose or vaccine component); screening for acute moderate or severe illness; documentation of informed consent; preparation of vaccine (refrigerated hepatitis B vaccine per manufacturer instructions); administration of intramuscular injection, typically into the deltoid for adults or anterolateral thigh for infants; observation for a brief period for adverse reaction; documentation in the medical record and immunization registry; and billing using the HCPCS Level II code G0010 for the vaccine administration when applicable to the payor’s billing rules. Common sites of service are outpatient clinic, physician office, public health clinic, long-term care facility, and pharmacy-based clinics that bill appropriate payors. Typical scenario: a 32-year-old newly hired nurse with no documented hepatitis B vaccination receives dose 1 of the hepatitis B series at an occupational health visit, screened for contraindications, administered intramuscularly in the deltoid, observed 15 minutes, and the encounter is billed using G0010 with applicable modifiers for payer requirements and provider circumstances.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    90460Immunization administration through 18 years of age with counseling by physician or other qualified health care professional; first vaccine/toxoid componentUsed for pediatric encounters where counseling is provided for the first vaccine component; often accompanies hepatitis B vaccine in children
    90461Immunization administration through 18 years of age with counseling; each additional vaccine/toxoid componentUsed when multiple vaccines are given during the same pediatric visit in addition to hepatitis B
    90471Immunization administration (including percutaneous, intradermal, subcutaneous, or intramuscular injections); single vaccine/toxoid/adultCommonly reported for adult vaccine administration when CPT-based billing is required instead of HCPCS
    90472Immunization administration; each additional vaccine (single or combination vaccine/toxoid)Used when more than one adult vaccine is administered during the same encounter alongside hepatitis B
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularUsed in some outpatient settings for administration of injectables when vaccine-specific codes are not used

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    207R00000X
    208000000X
    363LF0000X
    261QP2400X
    207RG0100X
    3336N0007X
    1223D0004X

    Related ICD-10-CM Codes

    23 rows

    ICD-10-CM CodeDescription
    A08.4Viral intestinal infection, unspecified
    A09Infectious gastroenteritis and colitis, unspecified
    B16.9Acute hepatitis B without delta-agent and without hepatic coma
    B18.1Chronic viral hepatitis B without delta-agent
    B18.2Chronic viral hepatitis C
    J02.9Acute pharyngitis, unspecified
    J06.9Acute upper respiratory infection, unspecified
    R10.9Unspecified abdominal pain
    R11.2Nausea with vomiting, unspecified
    R50.9Fever, unspecified

    Showing 1–10 of 23

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    HCPCS-G9490-HOME-ASSESSMENT-NON-HOMEBOUND

    HCPCS G9490: Home Visit Patient Assessment for Non-Homebound Beneficiary

    HCPCS-G0008-INFLUENZA-VACCINE-ADMINISTRATION

    HCPCS G0008: Administration of Influenza Virus Vaccine

    HCPCS-G0009-PNEUMOCOCCAL-VACCINE-ADMINISTRATION

    HCPCS G0009: Administration of Pneumococcal Vaccine

    HCPCS-G0011-PREP-COUNSELING-HIV-RISK-REDUCTION-ADHERENCE

    HCPCS G0011: Individual PrEP Counseling, HIV Risk Assessment

    HCPCS-G0012-PRE-EXPOSURE-PROPHYLAXIS-INJECTION-HIV-PREVENTION

    HCPCS G0012: Injection of PrEP Drug for HIV Prevention

    HCPCS-G0013-PREP-INDIVIDUAL-COUNSELING-HIV-RISK-REDUCTION

    HCPCS G0013: Individual PrEP Counseling by Clinical Staff

    HCPCS-G0017-PSYCHOTHERAPY-CRISIS-FIRST-60-MINUTES-NON-OFFICE

    HCPCS G0017: Psychotherapy for Crisis, First 60 Minutes

    HCPCS-G0018-PSYCHOTHERAPY-CRISIS-ADDITIONAL-30-MINUTES-NON-OFFICE

    HCPCS G0018: Psychotherapy for Crisis, Additional 30 Minutes

    HCPCS-G0019-COMMUNITY-HEALTH-INTEGRATION-SDOH-CARE-COORDINATION

    HCPCS G0019: Community Health Integration, Person-Centered Assessment

    HCPCS-G0022-COMMUNITY-HEALTH-INTEGRATION-ADDITIONAL-30-MIN

    HCPCS G0022: Community Health Integration, Additional 30 Minutes

    Showing 1–10 of 1996

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    90746
    Hepatitis B vaccine, adult dosage, dialysis patients; per dose
    Sometimes used for payer-specific coding of hepatitis B vaccine in dialysis populations when CPT vaccine codes are required