HCPCS Level II code G0455 denotes preparation with instillation of fecal microbiota by any method and includes assessment of the donor specimen. The code captures services related to fecal microbiota transplantation (FMT), a therapeutic procedure used to restore gut microbial balance in patients with certain gastrointestinal conditions. Nationally, accurate coding for this service matters for payer coverage determinations, clinical tracking, and public health surveillance as interest in microbiome-based therapies grows.

Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the code’s clinical scope, typical sites of service, and the kinds of benchmarks and policy elements commonly associated with FMT billing. The publication summarizes prevailing coverage considerations, coding practice notes, and operational implications for providers and billing teams.

This piece provides: (1) a clinical and coding summary of G0455; (2) benchmarking context for commonly involved payers; and (3) a policy and operational primer to support appropriate documentation and claims submission. Data not available in the input are explicitly noted where applicable.