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    v1.0.28
    OpenPayerBilling CodesProcedures / Professional ServicesHCPCS hcpcs-g0431-qualitative-multi-class-drug-screen-high-complexity
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    HCPCS G0431: Drug Screen, Multiple Drug Classes, High-Complexity

    HCPCS Level II code G0431 describes a qualitative drug screen for multiple drug classes performed with a high-complexity test method (for example, immunoassay or enzyme assay), reported per patient encounter; the service is a laboratory toxicology screening typically performed in clinical laboratories or hospital laboratory settings and billed as a single encounter-based diagnostic test.

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    Table of contents

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    Explore openpayer tools

    • Billing CodesCPT, HCPCS, DRG & more
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    • ModifiersCPT modifiers & usage
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    Clinical & Coding Specifications

    Clinical Context

    A patient presents to an outpatient addiction medicine clinic for routine monitoring of medication-assisted treatment and suspected nonadherence. The patient is a 38-year-old receiving buprenorphine for opioid use disorder who reports ongoing cravings. The clinician orders a point-of-care or clinic laboratory drug screen to assess recent use of opioids, benzodiazepines, amphetamines, cocaine, and other common substances. A phlebotomy technician collects a urine specimen during the same visit. The laboratory performs a qualitative, high-complexity immunoassay panel covering multiple drug classes, with results available the same day to guide treatment decisions. The clinic documents medical necessity, the encounter diagnosis (e.g., opioid use disorder), specimen source, and the time of collection. Billing uses HCPCS code G0431 for the high-complexity multiple drug class qualitative screen for that patient encounter. Modifier 26 may be appended when billing only the professional component is reported by the interpreting physician; modifier TC may be appended when billing only the technical component performed by the laboratory or facility. Typical sites of service include outpatient clinics, substance use disorder treatment programs, and hospital outpatient departments where laboratory immunoassay testing is performed.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81003Urinalysis, by dipstick or tablet reagent; non-automated, without microscopyOften performed at or before specimen collection to assess urine validity and provide adjunct information.
    80305Drug test(s), presumptive, any number of drug classes; non-quantitative screen, multiple drug classes by high complexity test methodAlternative laboratory-level CPT for presumptive drug testing; similar clinical purpose when a CPT code is used instead of HCPCS.
    80307Drug test(s), presumptive, definitive, any number of drug classes; chromatographic method (eg, GC, LC), single drug class quantitativeUsed when confirmatory or definitive testing by chromatography is required after a positive immunoassay screen.
    80310Drug test(s), definitive, qualitative or quantitative, multiple drug classes by mass spectrometry or chromatographic methodUsed for confirmatory testing following a positive or unexpected G0431 result; higher specificity than immunoassay.
    36415Collection of venous blood by venipunctureIf blood is required for confirmatory testing or additional toxicology assays, this CPT is billed for specimen collection.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    3PThe CPT Category II modifier -3P denotes a performance‑measure exclusion when a required quality action was not performed because of system‑level constraints. It is appended only to Category II…- When to apply: Use CPT Category II modifier 3P only with Category II (‘‘F’’) codes when a specific quality measure’s specifications allow a system‑level exclusion — append 3P to indicate the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    261QR0400XRehabilitation Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    3336C0003XCommunity/Retail PharmacyA pharmacy where pharmacists store, prepare, and dispense medicinal preparations and/or prescriptions for a local patient population in accordance wit…
    332S00000XHearing Aid EquipmentThe manufacture and/or sale of electronic hearing aids, their component parts, and related products and services on a national basis.
    163WH1000XHospice Registered NurseNursing Service Providers · Registered Nurse
    364SX0204XPediatric Oncology Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist

    Related Codes

    HCPCS-G9490-HOME-ASSESSMENT-NON-HOMEBOUND

    HCPCS G9490: Home Visit Patient Assessment for Non-Homebound Beneficiary

    HCPCS-G0008-INFLUENZA-VACCINE-ADMINISTRATION

    HCPCS G0008: Administration of Influenza Virus Vaccine

    HCPCS-G0009-PNEUMOCOCCAL-VACCINE-ADMINISTRATION

    HCPCS G0009: Administration of Pneumococcal Vaccine

    HCPCS-G0010-HEPATITIS-B-VACCINE-ADMINISTRATION

    HCPCS G0010: Administration of Hepatitis B Vaccine

    HCPCS-G0011-PREP-COUNSELING-HIV-RISK-REDUCTION-ADHERENCE

    HCPCS G0011: Individual PrEP Counseling, HIV Risk Assessment

    HCPCS-G0012-PRE-EXPOSURE-PROPHYLAXIS-INJECTION-HIV-PREVENTION

    HCPCS G0012: Injection of PrEP Drug for HIV Prevention

    HCPCS-G0013-PREP-INDIVIDUAL-COUNSELING-HIV-RISK-REDUCTION

    HCPCS G0013: Individual PrEP Counseling by Clinical Staff

    HCPCS-G0017-PSYCHOTHERAPY-CRISIS-FIRST-60-MINUTES-NON-OFFICE

    HCPCS G0017: Psychotherapy for Crisis, First 60 Minutes

    HCPCS-G0018-PSYCHOTHERAPY-CRISIS-ADDITIONAL-30-MINUTES-NON-OFFICE

    HCPCS G0018: Psychotherapy for Crisis, Additional 30 Minutes

    HCPCS-G0019-COMMUNITY-HEALTH-INTEGRATION-SDOH-CARE-COORDINATION

    HCPCS G0019: Community Health Integration, Person-Centered Assessment

    Showing 1–10 of 1996

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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