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HCPCS G0306: Complete CBC with Automated WBC Differential

HCPCS Level II code G0306 represents an automated complete blood count (CBC) that includes hemoglobin, hematocrit, red blood cell and white blood cell measurements (without platelet count) plus an automated white blood cell differential. As a common diagnostic hematology panel, it is widely used in outpatient and clinical laboratory settings for initial evaluation of infections, hematologic disorders and routine monitoring of medical conditions. Nationally, this code matters because CBCs are among the most frequently ordered laboratory tests and drive utilization, payment and quality-measure workflows across payers.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare and Medicare. Readers will find a concise overview of what G0306 represents clinically, where the service is typically performed and which major payers reimburse for the procedure. The publication summarizes benchmark considerations, coding context and areas where policy updates or payer coverage language can affect billing for automated CBC with differential. It also provides clinical context to help billing and compliance teams understand how this laboratory panel fits into common diagnostic pathways.

Data not available in the input for associated taxonomies, ICD-10 diagnoses, related codes, and service-line level details.

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Billing Code Overview

HCPCS Level II code G0306 describes a complete CBC, automated (Hgb, Hct, RBC, WBC, without platelet count) and automated WBC differential count. This service is a laboratory diagnostic hematology test that provides an automated panel measuring red and white blood cell parameters and a differential to classify white blood cell types.

Service type: Laboratory diagnostic hematology panel

Typical site of service: Clinical laboratory or outpatient laboratory draw site, including hospital outpatient laboratories and independent diagnostic laboratories.

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HCPCS G0306: Complete CBC with Automated WBC Differential

Data not available in the input for associated taxonomies, ICD-10 diagnoses, related codes, and service-line level details.

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Billing Code Overview

Service type: Laboratory diagnostic hematology panel

Typical site of service: Clinical laboratory or outpatient laboratory draw site, including hospital outpatient laboratories and independent diagnostic laboratories.

Clinical & Coding Specifications

Clinical Context

A 68-year-old male with a history of chronic anemia and new onset fatigue presents to an outpatient laboratory order placed by his primary care provider. The clinician orders a complete CBC with automated analysis of hemoglobin, hematocrit, RBC, WBC (without platelet count) and an automated WBC differential to evaluate for causes of anemia and leukocyte abnormalities. The patient presents to a freestanding clinical laboratory or hospital outpatient phlebotomy draw station. Blood is collected by phlebotomy staff, labeled, and sent to the automated hematology analyzer. Results are reviewed by the ordering clinician and documented in the electronic medical record; abnormal findings prompt further evaluation such as iron studies, reticulocyte count, peripheral smear, or hematology referral. Typical sites of service include outpatient laboratory, physician office with on-site lab, hospital outpatient lab, or ambulatory surgery center when part of pre-procedure testing.

Coding Specifications

Modifier	Description	When to Use
`00`	Default — no modifier	Use when no specific modifier applies and service is submitted as standard.
`11`	Normal, routine service	Use to indicate a routine, medically necessary laboratory service when payer requires this distinction.
`22`	Increased procedural services	Rarely used for lab codes; use if extra work or complexity documented beyond typical automated analysis.
`26`	Professional component	Use when reporting only the physician or professional interpretation portion distinct from the technical component.
`52`	Reduced services	Use when the full scope of the test was not completed and documentation supports reduced service.
`53`	Discontinued procedure	Use if specimen collection was attempted but procedure discontinued for documented reason.
`54`	Surgical care only	Not typically used for lab testing; included for cases when laboratory testing is part of a global surgical package and only the surgical portion is reported elsewhere.
`90`	Reference (outside) lab	Use when test performed by an outside reference laboratory and billing requires indication of outsourced testing.
`TC`	Technical component	Use when billing only the laboratory’s technical component of the test (instrumentation, reagents, tech time).
`QX`	Ordering clinician modifier for CLIA-waived specimen collection (supply)	Use when the ordered test requires a qualifying practitioner-performed service modifier (per payer rules).

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine	Primary care clinicians commonly order CBC testing.
207R00000X	Internal Medicine	Internists frequently order and interpret hematology panels.
207K00000X	Emergency Medicine	ED providers order CBCs for acute presentations.
2080P0002X	Clinical Pathology	Pathologists and laboratory medicine specialists oversee testing quality and interpretation.
2085R0208X	Hematology	Hematologists manage interpretation and follow-up for abnormal CBC/differential results.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`D50.9`	Iron deficiency anemia, unspecified	Common indication to obtain CBC and differential to evaluate anemia severity.
`D64.9`	Anemia, unspecified	General reason for CBC testing when etiology not yet established.
`R53.83`	Other fatigue	Nonspecific symptom leading to CBC to assess for anemia or infection.
`R50.9`	Fever, unspecified	CBC with differential is commonly ordered when infection is suspected.
`R73.9`	Hyperglycemia, unspecified	Metabolic disturbance that may be evaluated concurrently with CBC in outpatient workup.
`C91.10`	Chronic lymphocytic leukemia of unspecified cell type not having achieved remission	Hematologic malignancies often prompt CBC with automated differential for monitoring and diagnosis.
`D69.9`	Hemorrhagic condition, unspecified	Bleeding disorders or active bleeding often necessitate CBC testing for hemoglobin evaluation.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80053`	Comprehensive metabolic panel; blood chemistry tests performed together	Often ordered concurrently to assess metabolic contributors to anemia or systemic illness.
`85025`	Blood count; complete (CBC) automated, with auto differential WBC count	Clinical equivalent CPT frequently used for full CBC with platelets; may be ordered alongside or instead depending on payer coding rules.
`85014`	Blood count; Hemoglobin or Hematocrit only	May be ordered when only hemoglobin/hematocrit monitoring is required instead of full panel.
`85018`	Blood count; Hemoglobin; quantitative, automated	Alternative single-parameter test sometimes used for monitoring anemia.
`88184`	Cytopathology, slide review by pathologist, per specimen	May be used when automated differential prompts a manual peripheral smear review by pathology.

HCPCS G9490: Home Visit Assessment for Non-Homebound Patients

HCPCS-G0008-INFLUENZA-VACCINE-ADMINISTRATION

HCPCS G0008: Influenza Virus Vaccine Administration

HCPCS-G0009-PNEUMOCOCCAL-VACCINE-ADMINISTRATION

HCPCS G0009: Administration of Pneumococcal Vaccine

HCPCS-G0010-HEPATITIS-B-VACCINE-ADMINISTRATION

HCPCS G0010: Administration of Hepatitis B Vaccine

HCPCS-G0011-PREP-COUNSELING-HIV-RISK-REDUCTION-ADHERENCE

HCPCS G0011: Individual PrEP Counseling, HIV Risk Assessment

HCPCS-G0012-PRE-EXPOSURE-PROPHYLAXIS-INJECTION-HIV-PREVENTION

HCPCS G0012: Injection of Pre-Exposure Prophylaxis (PrEP) for HIV Prevention

HCPCS-G0013-PREP-INDIVIDUAL-COUNSELING-HIV-RISK-REDUCTION

HCPCS G0013: Individual PrEP Counseling and HIV Risk Assessment

HCPCS-G0017-PSYCHOTHERAPY-CRISIS-FIRST-60-MINUTES-NON-OFFICE

HCPCS G0017: Psychotherapy for Crisis, First 60 Minutes

HCPCS-G0018-PSYCHOTHERAPY-CRISIS-ADDITIONAL-30-MINUTES-NON-OFFICE

HCPCS G0018: Psychotherapy for Crisis, Additional 30 Minutes

HCPCS-G0019-COMMUNITY-HEALTH-INTEGRATION-SDOH-CARE-COORDINATION

HCPCS G0019: Community Health Integration for Social Determinants of Health

Showing 1–10 of 1996

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`00`	Default — no modifier	Use when no specific modifier applies and service is submitted as standard.
`11`	Normal, routine service	Use to indicate a routine, medically necessary laboratory service when payer requires this distinction.
`22`	Increased procedural services	Rarely used for lab codes; use if extra work or complexity documented beyond typical automated analysis.
`26`	Professional component	Use when reporting only the physician or professional interpretation portion distinct from the technical component.
`52`	Reduced services	Use when the full scope of the test was not completed and documentation supports reduced service.
`53`	Discontinued procedure	Use if specimen collection was attempted but procedure discontinued for documented reason.
`54`	Surgical care only	Not typically used for lab testing; included for cases when laboratory testing is part of a global surgical package and only the surgical portion is reported elsewhere.
`90`	Reference (outside) lab	Use when test performed by an outside reference laboratory and billing requires indication of outsourced testing.
`TC`	Technical component	Use when billing only the laboratory’s technical component of the test (instrumentation, reagents, tech time).
`QX`	Ordering clinician modifier for CLIA-waived specimen collection (supply)	Use when the ordered test requires a qualifying practitioner-performed service modifier (per payer rules).

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine	Primary care clinicians commonly order CBC testing.
207R00000X	Internal Medicine	Internists frequently order and interpret hematology panels.
207K00000X	Emergency Medicine	ED providers order CBCs for acute presentations.
2080P0002X	Clinical Pathology	Pathologists and laboratory medicine specialists oversee testing quality and interpretation.
2085R0208X	Hematology	Hematologists manage interpretation and follow-up for abnormal CBC/differential results.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`D50.9`	Iron deficiency anemia, unspecified	Common indication to obtain CBC and differential to evaluate anemia severity.
`D64.9`	Anemia, unspecified	General reason for CBC testing when etiology not yet established.
`R53.83`	Other fatigue	Nonspecific symptom leading to CBC to assess for anemia or infection.
`R50.9`	Fever, unspecified	CBC with differential is commonly ordered when infection is suspected.
`R73.9`	Hyperglycemia, unspecified	Metabolic disturbance that may be evaluated concurrently with CBC in outpatient workup.
`C91.10`	Chronic lymphocytic leukemia of unspecified cell type not having achieved remission	Hematologic malignancies often prompt CBC with automated differential for monitoring and diagnosis.
`D69.9`	Hemorrhagic condition, unspecified	Bleeding disorders or active bleeding often necessitate CBC testing for hemoglobin evaluation.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80053`	Comprehensive metabolic panel; blood chemistry tests performed together	Often ordered concurrently to assess metabolic contributors to anemia or systemic illness.
`85025`	Blood count; complete (CBC) automated, with auto differential WBC count	Clinical equivalent CPT frequently used for full CBC with platelets; may be ordered alongside or instead depending on payer coding rules.
`85014`	Blood count; Hemoglobin or Hematocrit only	May be ordered when only hemoglobin/hematocrit monitoring is required instead of full panel.
`85018`	Blood count; Hemoglobin; quantitative, automated	Alternative single-parameter test sometimes used for monitoring anemia.
`88184`	Cytopathology, slide review by pathologist, per specimen	May be used when automated differential prompts a manual peripheral smear review by pathology.

HCPCS G9490: Home Visit Assessment for Non-Homebound Patients

HCPCS-G0008-INFLUENZA-VACCINE-ADMINISTRATION

HCPCS G0008: Influenza Virus Vaccine Administration

HCPCS-G0009-PNEUMOCOCCAL-VACCINE-ADMINISTRATION

HCPCS G0009: Administration of Pneumococcal Vaccine

HCPCS-G0010-HEPATITIS-B-VACCINE-ADMINISTRATION

HCPCS G0010: Administration of Hepatitis B Vaccine

HCPCS-G0011-PREP-COUNSELING-HIV-RISK-REDUCTION-ADHERENCE

HCPCS G0011: Individual PrEP Counseling, HIV Risk Assessment

HCPCS-G0012-PRE-EXPOSURE-PROPHYLAXIS-INJECTION-HIV-PREVENTION

HCPCS G0012: Injection of Pre-Exposure Prophylaxis (PrEP) for HIV Prevention

HCPCS-G0013-PREP-INDIVIDUAL-COUNSELING-HIV-RISK-REDUCTION

HCPCS G0013: Individual PrEP Counseling and HIV Risk Assessment

HCPCS-G0017-PSYCHOTHERAPY-CRISIS-FIRST-60-MINUTES-NON-OFFICE

HCPCS G0017: Psychotherapy for Crisis, First 60 Minutes

HCPCS-G0018-PSYCHOTHERAPY-CRISIS-ADDITIONAL-30-MINUTES-NON-OFFICE

HCPCS G0018: Psychotherapy for Crisis, Additional 30 Minutes

HCPCS-G0019-COMMUNITY-HEALTH-INTEGRATION-SDOH-CARE-COORDINATION

HCPCS G0019: Community Health Integration for Social Determinants of Health

Showing 1–10 of 1996

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

HCPCS G0306: Complete CBC with Automated WBC Differential

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Billing Code Overview

OpenPayer

HCPCS G0306: Complete CBC with Automated WBC Differential

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References