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    OpenPayerBilling CodesOutpatient PPSHCPCS hcpcs-c7526-coronary-angiography-left-heart-catheterization-flow-measurement
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    HCPCS Level II C7526: Coronary Angiography with Left Heart Catheterization and CFR Measurement

    HCPCS Level II code C7526 describes catheter placement in coronary artery(ies) for coronary angiography with intraprocedural injections, imaging supervision and interpretation, left heart catheterization with ventriculography when performed, catheterization of bypass grafts with graft angiography, and intravascular Doppler velocity and/or pressure-derived coronary flow reserve measurement for the initial coronary vessel or graft during coronary angiography; this is an advanced cardiovascular diagnostic and interventional imaging service typically performed in a cardiac catheterization laboratory (inpatient or outpatient hospital setting) or specialized ambulatory surgical center and includes image acquisition, hemodynamic measurements, and interpretation.

    For related coverage guidance, see recent payer policy updates: Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA), Cardiovascular Disease Risk Assessment, Biomarkers for Myocardial Infarction and Chronic Heart Failure.

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    Clinical & Coding Specifications

    Clinical Context

    A 67-year-old male with a history of hypertension, hyperlipidemia, and prior coronary artery bypass grafting presents to the emergency department with exertional chest pain and new ischemic changes on ECG. Noninvasive testing is equivocal for ischemia. The interventional cardiology team schedules a diagnostic coronary angiography with left heart catheterization and coronary flow reserve measurement to assess native coronary arteries and bypass grafts.

    Procedure workflow: the patient is prepped in a cardiac catheterization laboratory. Conscious sedation or monitored anesthesia care is provided based on anesthesiology evaluation. Vascular access is obtained (typically femoral or radial). Selective catheterization of coronary ostia is performed with intraprocedural contrast injections for coronary angiography. Left heart catheterization is performed with left ventriculography when indicated. Catheterization of bypass grafts (internal mammary, saphenous vein or arterial grafts) is performed with graft angiography. Intravascular Doppler velocity and/or pressure-derived coronary flow reserve (CFR) measurements are performed in the initial coronary vessel or graft during pharmacologic stress when clinically indicated. Imaging supervision and interpretation are documented by the attending interventional cardiologist, procedural findings recorded, and post-procedure hemostasis and recovery arranged in the cath lab recovery area or same-day observation unit.

    Typical site of service: hospital outpatient department (cardiac catheterization laboratory) or inpatient cardiac catheterization lab when performed during an admission.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    93458Catheterization of coronary artery(ies), including intraprocedural injections for coronary angiography, imaging supervision and interpretation, with left heart catheterization including intraprocedural injection(s) for left ventriculography, when performed; with right heart catheterization including measurement of oxygen saturation and cardiac output, when performedOften reported for comprehensive diagnostic coronary angiography with both left and right heart catheterizations when performed in the same session.
    93459Added to 93458 for additional vessel graft angiography or when separate reporting for additional procedures is requiredUsed when additional distinct coronary or graft vessel evaluations require separate coding per payer rules.
    93463Injection procedure during pharmacologic stress imaging for assessment of coronary flow reserveReported when pharmacologic stress with imaging and CFR assessment is performed as part of angiographic evaluation.
    92980Percutaneous transluminal coronary thrombectomyMay be performed during the same session if intracoronary thrombus is identified and requires mechanical thrombectomy.
    93460Catheter placement in coronary artery(ies) for coronary angiography, including imaging supervision and interpretation; with left heart catheterization including ventriculography, when performed; with coronary flow reserve measurement (when performed)Related code variant describing CFR measurement; used per payer coding guidance when separate reporting is appropriate.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208800000XUrology PhysicianA urologist manages benign and malignant medical and surgical disorders of the genitourinary system and the adrenal gland. This specialist has compreh…
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    1223P0221XPediatric DentistryAn age-defined specialty that provides both primary and comprehensive preventive and therapeutic oral health care for infants and children through ado…
    2471V0105XVascular Sonography Radiologic TechnologistA radiologic technologist who specializes in vascular sonography and is trained in the use of ultrasound equipment to image veins and arteries, which …
    2083P0500XPreventive Medicine/Occupational Environmental Medicine PhysicianA preventive medicine physician who specializes in preventive medicine/occupational-environmental medicine, which is focused on protecting the populat…

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    E11.9Type 2 diabetes mellitus without complications
    E78.5Hyperlipidemia, unspecified
    I20.0Unstable angina
    I20.9Angina pectoris, unspecified
    I21.09ST elevation (STEMI) myocardial infarction involving other coronary artery of anterior wall
    I21.4Non-ST elevation (NSTEMI) myocardial infarction
    I22.9Subsequent ST elevation (STEMI) myocardial infarction of unspecified site
    I25.10Atherosclerotic heart disease of native coronary artery without angina pectoris
    I25.110Atherosclerotic heart disease of native coronary artery with unstable angina pectoris
    I25.119Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA)univerahealthcare2026-10-15
    Cardiovascular Disease Risk AssessmentOscar Health2026-10-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2026-10-01
    Multiple Procedure Payment Reduction for Diagnostic Cardiovascular ProceduresBlue Cross Blue Shield - Maine2026-10-01
    Cardiovascular Disease Risk Assessmentblue cross blue shield - louisiana2026-09-15
    Cardiovascular Disease Risk AssessmentBlue Cross Blue Shield - New Mexico2026-09-04
    Computed Tomography to Detect Coronary Artery CalcificationBluecross Idaho2026-09-01
    Intracoronary Drug Delivery Balloon ProceduresBlue Cross Blue Shield - Rhode Island2026-09-01
    Cardiac Imaging Guidelinesevicore2026-09-01
    Percutaneous Left Atrial Appendage Closure Device for Stroke PreventionAmbetter Georgia2026-08-26

    Related Codes

    HCPCS-C1713-IMPLANTABLE-ANCHOR-SCREW-BONE-FIXATION

    HCPCS C1713: Anchor/Screw for Bone or Soft Tissue Fixation (Implantable)

    HCPCS-C1714-TRANSLUMINAL-DIRECTIONAL-ATHERECTOMY-CATHETER

    HCPCS C1714: Catheter, transluminal atherectomy, directional

    HCPCS-C1715-BRACHYTHERAPY-NEEDLE

    HCPCS C1715: Brachytherapy Needle

    HCPCS-C1716-BRACHYTHERAPY-GOLD-198-SOURCE

    HCPCS C1716: Brachytherapy Source, Gold-198, Per Source

    HCPCS-C1717-HDR-BRACHYTHERAPY-IRIDIUM-192-SOURCE

    HCPCS C1717: HDR Iridium-192 Brachytherapy Source, Per Source

    HCPCS-C1719-BRACHYTHERAPY-IRIDIUM-192-SOURCE-NON-STRANDED

    HCPCS C1719: Brachytherapy Source, Iridium-192, Non-Stranded

    HCPCS-C1721-IMPLANTABLE-DUAL-CHAMBER-CARDIOVERTER-DEFIBRILLATOR

    HCPCS C1721: Cardioverter-Defibrillator, Dual Chamber (Implantable)

    HCPCS-C1724-ROTATIONAL-TRANSLUMINAL-ATHERECTOMY-CATHETER

    HCPCS Level II C1724: Rotational Transluminal Atherectomy Catheter

    HCPCS-C1725-TRANSLUMINAL-ANGIOPLASTY-CATHETER-NON-LASER

    HCPCS Level II C1725: Transluminal Angioplasty Catheter, Non-Laser

    HCPCS-C1726-NON-VASCULAR-BALLOON-DILATATION-CATHETER

    HCPCS C1726: Catheter, Balloon Dilatation, Non-Vascular

    Showing 1–10 of 603

    • More pages

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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