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    OpenPayerBilling CodesAdministrative, Miscellaneous and InvestigationalHCPCS hcpcs-a9592-copper-cu64-dotatate-diagnostic-1-millicurie
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    HCPCS Level II A9592: Copper Cu-64 Dotatate Diagnostic, 1 Millicurie

    HCPCS Level II code A9592 describes a diagnostic radiopharmaceutical, copper Cu-64 dotatate, supplied in a 1 millicurie quantity for use in diagnostic PET imaging; the service involves preparation and provision of the radiotracer for administration, typically provided in a hospital outpatient imaging department or nuclear medicine/diagnostic imaging center for tumor or somatostatin receptor evaluation.

    For related coverage guidance, see recent payer policy updates: Interferential Stimulation Devices (for home use), Prior Authorization for Durable Medical Equipment (DME), Breast Pumps.

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    Table of contents

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    • Billing CodesCPT, HCPCS, DRG & more
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    • ModifiersCPT modifiers & usage
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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult being evaluated for suspected neuroendocrine tumor (NET) recurrence or metastatic disease. The patient presents with new or progressive symptoms such as flushing, diarrhea, abdominal pain, or unexplained weight loss and has prior imaging or biochemical markers suggestive of somatostatin receptor–expressing tumor. The clinical workflow includes referral from medical oncology or endocrinology to nuclear medicine or a radiology division for a PET/CT study using A9592 (Copper Cu-64, DOTATATE, diagnostic, 1 millicurie) as the radiopharmaceutical. On the day of service, the patient undergoes radiopharmaceutical administration per nuclear medicine protocols, a uptake period as specified by the imaging center, and PET/CT acquisition. Following image reconstruction and interpretation by a nuclear medicine physician or radiologist, a diagnostic report documents somatostatin receptor–avid lesions, compares with prior studies if available, and informs multidisciplinary care decisions such as peptide receptor radionuclide therapy candidacy or surgical planning. Typical sites of service are an outpatient hospital imaging center, freestanding imaging center, or academic medical center nuclear medicine department. The typical patient scenario may involve coordination of scheduling, pre-authorization for radiopharmaceuticals, and radiation safety procedures for handling Cu-64 DOTATATE.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    A9500Radiopharmaceutical, diagnostic, limited area, non-nuclear medicine, per study doseAdministrative/code-level companion for radiopharmaceutical supply; sometimes billed by radiopharmacy when applicable
    78813Positron emission tomography (PET) with concurrently acquired CT for attenuation correction and anatomic localization; skull base to mid-thighCommon PET/CT acquisition that accompanies A9592 when disease survey is needed
    78814PET with concurrently acquired CT; whole body, including brain to mid-thighUsed when whole-body imaging is required to evaluate metastatic NET
    763763D rendering with interpretation and reporting of nuclear medicine studies (list separately in addition to primary imaging)Used for advanced image processing or 3D visualization of somatostatin receptor–positive lesions
    A9512PET Quantification, non-covered/ancillary radiopharmaceutical billing code (example)Occasionally used for specialized quantification services or facility-level radiopharmaceutical cost reporting

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    2080B0002XPediatric Obesity Medicine PhysicianA physician who specializes in the treatment of obesity demonstrates competency in and a thorough understanding of the treatment of obesity and the ge…
    1835N1003XNutrition Support PharmacistA licensed pharmacist who has demonstrated specialized knowledge and skill in maintenance and/or restoration of optimal nutritional status, designing …
    207RA0401XAddiction Medicine (Internal Medicine) PhysicianAn internist doctor of osteopathy that specializes in the treatment of addiction disorders. A doctor of osteopathy that is board eligible/certified b…
    251G00000XCommunity Based Hospice Care AgencyAgencies · Hospice Care, Community Based
    146D00000XPersonal Emergency Response AttendantIndividuals that are specially trained to assist patients living at home with urgent/emergent situations. These individuals must be able to perform C…
    1835P0200XPediatric PharmacistA licensed pharmacist who has demonstrated specialized knowledge and skill in the delivery of patient care services by pharmacists that ensures the sa…

    Related ICD-10-CM Codes

    17 rows

    ICD-10-CM CodeDescription
    C78.7Secondary malignant neoplasm of liver and intrahepatic bile duct
    C79.31Secondary malignant neoplasm of brain
    C7A.011Malignant carcinoid tumor of the jejunum
    C7A.012Malignant carcinoid tumor of the ileum
    C7A.019Malignant carcinoid tumor of the small intestine, unspecified portion
    C7A.021Malignant carcinoid tumor of the cecum
    C7A.022Malignant carcinoid tumor of the ascending colon
    C7A.029Malignant carcinoid tumor of the large intestine, unspecified portion
    C7A.091Malignant carcinoid tumor of the thymus
    C7A.092Malignant carcinoid tumor of the stomach

    Showing 1–10 of 17

    Related Payer Policy Updates

    Specialty: Durable Medical Equipment (DME)1 / 3

    10 rows

    PolicyPayerEffective Date
    Interferential Stimulation Devices (for home use)Moda Health2026-10-01
    Prior Authorization for Durable Medical Equipment (DME)Blue Cross Blue Shield - Rhode Island2026-10-01
    Breast PumpsModa Health2026-09-01
    Personal Emergency Response SystemsCareSource Georgia2026-09-01
    Continuous Passive Motion (CPM) DevicesCigna2026-08-15
    Push-Rim Activated Power-Assist Device (E0986) — Manual Wheelchair Accessorymoda_health_plan_inc2026-08-13
    Beds and Mattresses (for Ohio Only)Colorado Rocky Mountain Health Plans2026-08-01
    Beds and Mattresses (for Kentucky Only)UnitedHealthcare2026-08-01
    Pneumatic Compression Devices (for Nebraska Only)UnitedHealthcare2026-08-01
    Indications for Coverage — Hospital beds, support surfaces, and safety enclosure beds (DME)Colorado Rocky Mountain Health Plans2026-08-01

    Related Codes

    HCPCS-A9150-NON-PRESCRIPTION-DRUGS

    HCPCS Level II A9150: Non-prescription Drugs

    HCPCS-A9152-SINGLE-ORAL-VITAMIN-MINERAL-DOSE

    HCPCS A9152: Single Oral Vitamin/Mineral/Trace Element

    HCPCS-A9153-MULTIVITAMIN-ORAL-PER-DOSE

    HCPCS A9153: Multiple Vitamins, Oral, Per Dose

    HCPCS-A9154-ARTIFICIAL-SALIVA-1ML

    HCPCS Level II A9154: Artificial saliva, 1 ml

    HCPCS-A9155-ARTIFICIAL-SALIVA-30ML

    HCPCS Level II A9155: Artificial Saliva, 30 mL

    HCPCS-A9156-ORAL-MUCOADHESIVE-PER-1ML

    HCPCS Level II A9156: Oral Mucoadhesive, Per 1 ml

    HCPCS-A9180-PEDICULOSIS-TOPICAL-TREATMENT-PATIENT-ADMINISTRATION

    HCPCS Level II A9180: Pediculosis Topical Treatment for Patient/Caretaker

    HCPCS-A9268-PROGRAMMER-TRANSIENT-INGESTED-CAPSULE

    HCPCS Level II A9268: Programmer for Transient Orally Ingested Capsule

    HCPCS-A9269-PROGRAMMABLE-TRANSIENT-ORAL-CAPSULE

    HCPCS Level II A9269: Programmable Orally Ingested Capsule, Per Month

    HCPCS-A9270-NON-COVERED-ITEM-OR-SERVICE

    HCPCS A9270: Non-covered Item or Service

    Showing 1–10 of 138

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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