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    OpenPayerBilling CodesMedical And Surgical SuppliesHCPCS hcpcs-a4641-radiopharmaceutical-diagnostic-noc
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    HCPCS Level II A4641: Radiopharmaceutical, Diagnostic, Not Otherwise Classified

    HCPCS Level II code A4641 identifies a diagnostic radiopharmaceutical classified as “not otherwise classified,” used for nuclear medicine imaging procedures; the service is a diagnostic radiopharmaceutical agent typically administered in an outpatient imaging or nuclear medicine department for diagnostic scans to evaluate physiologic or biochemical processes.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Bone Turnover Markers Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old patient with a known history of prostate cancer is referred for a diagnostic nuclear medicine study using a specialized radiopharmaceutical not otherwise classified (A4641) to evaluate suspected metastatic disease. The patient arrives at an outpatient nuclear medicine clinic or hospital radiology department. After registration and verification of allergies and pregnancy status, a nuclear medicine technologist confirms the radiopharmaceutical dose and prepares the tracer under institutional radiation safety protocols. The radiopharmaceutical labeled under A4641 is administered intravenously, with exact timing documented for image acquisition. The patient rests in a monitored uptake room for the appropriate biodistribution interval. Imaging is performed by a nuclear medicine technologist and interpreted by a nuclear medicine physician or radiologist. Post-procedure, the interpreting physician documents findings and a final report is issued for the referring oncologist.

    Typical site of service: outpatient nuclear medicine department, hospital radiology or ambulatory imaging center.

    Typical patient scenario: diagnostic evaluation for occult or metastatic disease, biochemical recurrence surveillance, or localization of disease when standard radiopharmaceuticals are not appropriate or available.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    78258Therapeutic radiopharmaceutical, by intravenous route; non-palliativePerformed when diagnostic radiopharmaceutical imaging precedes or is followed by therapeutic radiopharmaceutical administration in oncology workflows.
    78800Radiopharmaceutical localization of tumor; first study in a single dayMay be used for planar localization studies performed with a diagnostic radiopharmaceutical prior to or in conjunction with A4641 administration.
    78803Radiopharmaceutical localization of tumor; SPECT, single studyUsed when single-photon emission computed tomography imaging is performed after administration of the diagnostic radiopharmaceutical coded as A4641.
    78815PET imaging, tumor imaging; whole body, single studyUsed when a PET radiotracer (if applicable) and PET/CT imaging accompany diagnostic radiopharmaceutical administration for systemic disease evaluation.
    79005Radiopharmaceutical agent, diagnostic, per study dose, not otherwise classifiedUsed when a specific per-dose reporting of a non-standard diagnostic radiopharmaceutical is required alongside administration codes such as A4641.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    364S00000XClinical Nurse SpecialistA registered nurse who, through a graduate degree program in nursing, or through a formal post-basic education program or continuing education courses…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    163WX0200XOncology Registered NurseNursing Service Providers · Registered Nurse
    208M00000XHospitalist PhysicianHospitalists are physicians whose primary professional focus is the general medical care of hospitalized patients. Their activities include patient ca…
    101YM0800XMental Health CounselorBehavioral Health & Social Service Providers · Counselor
    2084V0102XVascular Neurology PhysicianVascular Neurology is a subspecialty in the evaluation, prevention, treatment and recovery from vascular diseases of the nervous system. This subspeci…

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    C50.911Malignant neoplasm of unspecified site of right female breast
    C71.9Malignant neoplasm of brain, unspecified
    C79.31Secondary malignant neoplasm of brain
    E11.9Type 2 diabetes mellitus without complications
    E78.5Hyperlipidemia, unspecified
    F33.1Major depressive disorder, recurrent, moderate
    G40.909Epilepsy, unspecified, not intractable, without status epilepticus
    I20.9Angina pectoris, unspecified
    I25.10Atherosclerotic heart disease of native coronary artery without angina pectoris
    I63.9Cerebral infarction, unspecified

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    5 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01

    Related Codes

    HCPCS-A4206-STERILE-SYRINGE-1CC-NEEDLE

    HCPCS A4206: Syringe with Needle, 1 cc or Less, Sterile

    HCPCS-A4207-STERILE-2CC-SYRINGE-WITH-NEEDLE

    HCPCS Level II A4207: Syringe with Needle, Sterile 2 cc

    HCPCS-A4208-STERILE-3CC-SYRINGE-WITH-NEEDLE

    HCPCS Level II A4208: Syringe with Needle, Sterile 3 cc

    HCPCS-A4209-STERILE-SYRINGE-WITH-NEEDLE-5CC-OR-GREATER

    HCPCS Level II A4209: Syringe with Needle, Sterile 5 cc or Greater

    HCPCS-A4210-NEEDLE-FREE-INJECTION-DEVICE

    HCPCS Level II A4210: Needle-free Injection Device, Each

    HCPCS-A4211-SUPPLIES-SELF-ADMINISTERED-INJECTIONS

    HCPCS Level II A4211: Supplies for Self-Administered Injections

    HCPCS-A4212-NON-CORING-NEEDLE-STYLET-CATHETER-ACCESS-SUPPLY

    HCPCS Level II A4212: Non-coring Needle or Stylet with/without Catheter

    HCPCS-A4213-STERILE-SYRINGE-20CC-OR-GREATER

    HCPCS Level II A4213: Syringe, Sterile, 20 cc or Greater, Each

    HCPCS-A4215-STERILE-NEEDLE-SINGLE-EACH

    HCPCS Level II A4215: Needle, Sterile, Any Size

    HCPCS-A4216-STERILE-DILUENT-FLUSH-10ML

    HCPCS Level II A4216: Sterile Diluent/Flush, 10 ml

    Showing 1–10 of 633

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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