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    v1.0.28
    OpenPayerBilling CodesHome Visit ServicesCPT cpt-99506-home-intramuscular-injection-home-visit
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    CPT 99506: Home Visit for Intramuscular Injection by Nurse

    CPT code 99506 describes a home health service in which a qualified provider, such as a registered nurse, visits a patient’s home to administer an intramuscular injection ordered by another clinician; this code captures the home visit service type with the typical site of service being the patient’s residence and is used for billing the professional visit and injection administration performed in the home setting.

    For related coverage guidance, see recent payer policy updates: Interferential Stimulation Devices (for home use), Durable Medical Equipment (DME): Tumor Treating Fields (Alternating Electric Field Therapy) Medical Guideline, Durable Medical Equipment (DME): Bone Growth Stimulators Medical Guideline.

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    Clinical & Coding Specifications

    Clinical Context

    A home health registered nurse (RN) or licensed practical nurse (LPN) receives a physician order to administer an intramuscular medication in the patient’s residence. Typical patients include homebound adults who require routine or one-time intramuscular injections such as seasonal influenza vaccine, intramuscular antibiotics for cellulitis when oral therapy is inappropriate, vitamin B12 for pernicious anemia, or depot antipsychotic injections for schizophrenia. The clinical workflow: the ordering provider documents the indication and medication, the home health agency schedules a visit, the nurse performs pre‑administration assessment (allergies, vital signs, review of contraindications), verifies the medication and dose, obtains informed consent when required, prepares and administers the intramuscular injection using appropriate technique and site selection, monitors the patient briefly for immediate adverse reaction, documents the administration (medication, lot number, site, route, patient tolerance), and communicates back to the ordering provider about completion and any adverse events. Billing uses the home visit administration code 99506 to represent the professional visit for administering an intramuscular medication in the patient’s residence.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    99211Office or other outpatient visit for the evaluation and management of an established patient, minimal problemsMay be billed by a nurse practitioner or physician for brief assessment or follow-up associated with home injection visits when E/M criteria are met.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularClinically similar CPT for administration of an injection in facility/outpatient settings; 99506 specifies a home visit administration.
    90471Immunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular) with counseling when performed; single or first vaccine/toxoidUsed when the visit is specifically for vaccine administration in many billing scenarios; check payer rules whether 90471 or 99506 is appropriate in home setting.
    99024Postoperative follow-up visit, normally included in the global serviceMay be used when a home visit addresses a post-procedure injection related to recent surgery follow-up when applicable.
    99501Home visit for the evaluation and management of a new patientRelated home visit E/M codes for initial home visit assessments that can precede medication administration during home care.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    163W00000XRegistered Nurse(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
    174400000XSpecialistAn individual educated and trained in an applied knowledge discipline used in the performance of work at a level requiring knowledge and skills beyond…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207RH0002XHospice and Palliative Medicine (Internal Medicine) PhysicianAn internal medicine physician with special knowledge and skills to prevent and relieve the suffering experienced by patients with life-limiting illne…
    122400000XDenturistA denturist is a licensed professional that serves patients with removable dental prosthetic oral health needs. A licensed denturist is trained in rem…
    1223X0400XOrthodontics and Dentofacial Orthopedics DentistryThat area of dentistry concerned with the supervision, guidance and correction of the growing or mature dentofacial structures, including those condit…
    207V00000XObstetrics & Gynecology PhysicianAn obstetrician/gynecologist possesses special knowledge, skills and professional capability in the medical and surgical care of the female reproducti…
    207X00000XOrthopaedic Surgery PhysicianAn orthopaedic surgeon is trained in the preservation, investigation and restoration of the form and function of the extremities, spine and associated…

    Related Payer Policy Updates

    Specialty: Durable Medical Equipment (DME)1 / 3

    5 rows

    PolicyPayerEffective Date
    Interferential Stimulation Devices (for home use)Moda Health2026-10-01
    Durable Medical Equipment (DME): Tumor Treating Fields (Alternating Electric Field Therapy) Medical GuidelineWPS Health Insurance2026-10-01
    Durable Medical Equipment (DME): Bone Growth Stimulators Medical GuidelineWPS Health Insurance2026-10-01
    General Durable Medical Equipment (DME) Medical GuidelineWPS Health Insurance2026-10-01
    Prior Authorization for Durable Medical Equipment (DME)Blue Cross Blue Shield - Rhode Island2026-10-01

    Related Codes

    CPT-99500-HOME-PRENATAL-MONITORING-ASSESSMENT

    CPT 99500: Prenatal Home Health Visit for Pregnancy Complications

    CPT-99501-POSTPARTUM-NEWBORN-HOME-VISIT

    CPT 99501: Home Health Visit for Postpartum and Newborn Follow-Up

    CPT-99502-NEWBORN-HOME-VISIT-NEWBORN-EVALUATION-EDUCATION

    CPT 99502: Newborn Home Visit for Evaluation and Education

    CPT-99503-HOME-RESPIRATORY-THERAPY-NON-PHYSICIAN-PROVIDER

    CPT 99503: Respiratory Therapy in Patient's Home

    CPT-99504-HOME-MECHANICAL-VENTILATION-CARE-RESPIRATORY-THERAPIST

    CPT 99504: Home Mechanical Ventilation Care by Respiratory Therapist

    CPT-99505-HOME-VISIT-STOMA-CARE

    CPT 99505: Home Visit for Stoma Care

    CPT-99507-HOME-HEALTH-CATHETER-ASSESSMENT

    CPT 99507: Home Health Catheter Evaluation

    CPT-99509-HOME-HEALTH-ADL-SELF-CARE-VISIT

    CPT 99509: Home Health Visit for ADL and Self-Care Support

    CPT-99510-HOME-COUNSELING-PSYCHOLOGIST-SOCIAL-WORKER

    CPT 99510: Home Counseling by Psychologist or Social Worker

    CPT-99511-HOME-MANAGEMENT-AND-REMOVAL-OF-FECAL-IMPACTION

    CPT 99511: Home Visit for Fecal Impaction Management and Removal

    Showing 1–10 of 12

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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