CPT code 96422 identifies the initial hour of intra-arterial chemotherapy infusion using an infusion technique. The code captures a specialized, procedure-based chemotherapy delivery method that concentrates cytotoxic agents in the vascular territory of a tumor, often used in interventional oncology and complex infusion programs. Nationally, accurate coding for intra-arterial infusions affects clinical documentation, claims adjudication, and consistent reporting of high-complexity oncology procedures.

Key payers addressed in this overview include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise explanation of the clinical and service context for CPT code 96422, plus an outline of typical sites of service and common operational considerations. The publication provides benchmarking and policy context where available, highlights coding boundaries for the initial hour of infusion, and summarizes implications for billing workflows and claims processing. Where specific payer policies, fee schedules, or applicable modifiers are not provided in the input, the text notes that those details are not available.

This summary is intended for national audiences including coding professionals, revenue cycle managers, and clinical teams involved in interventional oncology and chemotherapy delivery, offering a clear reference to support accurate use of CPT code 96422.