CPT code 91321 describes a SARS–CoV–2 vaccine product supplied for intramuscular administration at a 25 mcg/0.25 mL dosage to reduce the patient’s risk of COVID–19; the service is a vaccine administration by intramuscular injection typically provided in outpatient clinic settings, primary care offices, public health clinics, or pharmacies where intramuscular immunizations are delivered.

For related coverage guidance, see recent payer policy updates: B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays, Hepatitis Testing (A, B, C, D) Coverage Criteria.