CPT code 87627 describes a multiplex nucleic acid amplification and probe hybridization test that detects 26 or more pathogens and drug resistance genes from a specimen collected from a joint space (for example, synovial fluid from the knee or hip); service type: molecular infectious disease testing (multiplex PCR/NAAT); typical site of service: clinical laboratory processing synovial/joint fluid specimens, often ordered from outpatient clinics, emergency departments, or inpatient settings for evaluation of septic arthritis or prosthetic joint infection.

For related coverage guidance, see recent payer policy updates: B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays, Hepatitis Testing (A, B, C, D) Coverage Criteria.