CPT code 87391 identifies a laboratory immunoassay performed to detect antigens of human immunodeficiency virus 2 (HIV-2). This test plays a role in diagnosing or screening for HIV-2 infection and is relevant to public health surveillance, infectious disease management, and laboratory service billing on a national scale. Accurate coding for antigen detection is important for clinical decision-making, reporting, and reimbursement workflows across payers.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical context for antigen-based HIV-2 testing, the typical laboratory and site-of-service settings where the test is performed, and the payer landscape relevant to claims processing. The publication outlines common billing modifiers and identifies where input data is not available.

The report helps readers understand the purpose of CPT code 87391, how it fits into laboratory infectious disease testing, and what to expect when preparing claims for major commercial payers and Medicare. Data not available in the input is explicitly noted where relevant.