CPT 86147: Cardiolipin (Antiphospholipid) Antibody Test

CPT code 86147 describes a laboratory technical test for detection of antibodies to cardiolipin (antiphospholipids); report once for each immunoglobulin class tested. Service type: clinical laboratory immunoassay performed by a lab analyst; typical site of service: clinical laboratory or hospital lab where blood or serum specimens are analyzed.

For related coverage guidance, see recent payer policy updates: Diagnosis of Idiopathic Environmental Intolerance, Allergen Testing, Allergen Testing.

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CPT 86147: Cardiolipin (Antiphospholipid) Antibody Test

For related coverage guidance, see recent payer policy updates: Diagnosis of Idiopathic Environmental Intolerance, Allergen Testing, Allergen Testing.

Customize your policy alerts

Sign up for cpt 86147 policy alerts

Get alerted when payer policies referencing 86147 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A 34-year-old female presents to a hematology clinic with a history of recurrent first-trimester pregnancy loss and a prior unexplained deep vein thrombosis. Her hematologist orders serologic testing for antiphospholipid antibodies, including anticardiolipin antibodies (IgG and IgM) to evaluate for antiphospholipid syndrome. A phlebotomy technician draws blood in the outpatient laboratory. The laboratory analyst performs the technical assay corresponding to 86147 to detect antibodies to cardiolipin; the test is reported separately for each immunoglobulin class tested (for example, once for IgG and once for IgM). Results are sent to the ordering clinician and incorporated into the diagnostic workup and management plan. Typical sites of service are outpatient ambulatory laboratory or hospital clinical laboratory performing immunology serology testing.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`36415`	Collection of venous blood by venipuncture	Performed prior to `86147` to obtain the specimen for cardiolipin antibody testing.
`86038`	Antibody; erythrocyte antibody detection (indirect antiglobulin test)	Other immunology serology tests that may be ordered in a hematologic workup alongside antiphospholipid testing.
`86316`	Antibody; direct antiglobulin (Coombs)	Related immunohematology testing that may be performed in patients with suspected autoimmune conditions.
`86765`	Antibody; HIV-1/2, confirmatory, including immunoassays	Example of serologic confirmatory testing workflow; laboratories may perform multiple serologic assays during evaluation.
`99000`	Handling and/or conveyance of specimen	Ancillary services associated with specimen transport and handling for reference lab testing such as `86147`.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
95	Modifier 95 indicates that a service was provided via synchronous, real‑time audio‑video telehealth rather than in‑person. Per CMS, AAPC and professional associations, append modifier 95 to claim…	- Use modifier 95 to indicate a service was furnished via synchronous, real‑time audiovisual telehealth (a live audio‑video conference between patient and provider) rather than in‑person. - Pair…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
226300000X	Kinesiotherapist	A provider trained and educated in the applied science of medically prescribed therapeutic exercise, education and adapted physical activities designe…
207XS0117X	Orthopaedic Surgery of the Spine Physician	Recognized by several state medical boards as a fellowship subspecialty program of orthopaedic surgery, orthopaedic surgeons of the spine deal with th…
364SS0200X	School Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
364SL0600X	Long-Term Care Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist

Related Payer Policy Updates

Specialty: Allergy/Clinical Immunology1 / 3

10 rows

Policy	Payer	Effective Date
Diagnosis of Idiopathic Environmental Intolerance	Oscar Health	2026-10-01
Allergen Testing	blue cross blue shield - louisiana	2026-09-15
Allergen Testing	Blue Cross Blue Shield - New Mexico	2026-09-04
Hereditary Angioedema - Ekterly	Cigna	2026-08-15
Omalizumab products (Xolair, Omlyclo) coverage	Premera Bluecross	2026-08-01
Omalizumab Products (Xolair, Omlyclo) coverage	Premera Bluecross	2026-08-01
Omalizumab Products	Premera Bluecross	2026-08-01
Allergy Testing	univerahealthcare	2026-07-16
EBGLYSS (lebrikizumab-lbkz) prior authorization for atopic dermatitis	Mississippi Division of Medicaid	2026-07-01
Xolair (omalizumab) (Subcutaneous) — Concomitant therapy restrictions and dosing guidance	eocco	2026-07-01

CPT 86803: Hepatitis C Antibody Immunoassay in Serum

CPT-86000-FEBRILE-AGGLUTININS-SEROLOGIC-TEST

CPT 86000: Febrile Agglutinins (Serologic Agglutination) Test

CPT-86001-ALLERGEN-SPECIFIC-IGG-LABORATORY-TEST

CPT 86001: Allergen-Specific IgG Assay, Technical Component

CPT-86003-ALLERGEN-SPECIFIC-IGE-ASSAY-TECHNICAL

CPT 86003: Allergen‑Specific IgE Assay Using Crude Allergen Extract

CPT-86005-MULTI-ALLERGEN-IGE-SCREENING-QUALITATIVE

CPT 86005: Multi-Allergen Allergen-Specific IgE Screening

CPT-86008-ALLERGEN-COMPONENT-SPECIFIC-IGE-ASSAY

CPT 86008: Allergen Component–Specific IgE Assay

CPT-86015-ANTI-ACTIN-SMOOTH-MUSCLE-ANTIBODY-ASMA

CPT 86015: Actin (Smooth Muscle) Antibody (ASMA) Immunoassay

CPT-86021-LEUKOCYTE-ANTIBODY-IDENTIFICATION-LAB-TECHNICAL

CPT 86021: Leukocyte Antibody Identification Laboratory Test

CPT-86022-PLATELET-ANTIBODY-IDENTIFICATION-TECHNICAL-TEST

CPT 86022: Platelet Antibody Detection and Identification

CPT-86023-PLATELET-ASSOCIATED-IMMUNOGLOBULIN-DETECTION

CPT 86023: Platelet-Associated Immunoglobulin Assay

Showing 1–10 of 199

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`36415`	Collection of venous blood by venipuncture	Performed prior to `86147` to obtain the specimen for cardiolipin antibody testing.
`86038`	Antibody; erythrocyte antibody detection (indirect antiglobulin test)	Other immunology serology tests that may be ordered in a hematologic workup alongside antiphospholipid testing.
`86316`	Antibody; direct antiglobulin (Coombs)	Related immunohematology testing that may be performed in patients with suspected autoimmune conditions.
`86765`	Antibody; HIV-1/2, confirmatory, including immunoassays	Example of serologic confirmatory testing workflow; laboratories may perform multiple serologic assays during evaluation.
`99000`	Handling and/or conveyance of specimen	Ancillary services associated with specimen transport and handling for reference lab testing such as `86147`.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
95	Modifier 95 indicates that a service was provided via synchronous, real‑time audio‑video telehealth rather than in‑person. Per CMS, AAPC and professional associations, append modifier 95 to claim…	- Use modifier 95 to indicate a service was furnished via synchronous, real‑time audiovisual telehealth (a live audio‑video conference between patient and provider) rather than in‑person. - Pair…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
226300000X	Kinesiotherapist	A provider trained and educated in the applied science of medically prescribed therapeutic exercise, education and adapted physical activities designe…
207XS0117X	Orthopaedic Surgery of the Spine Physician	Recognized by several state medical boards as a fellowship subspecialty program of orthopaedic surgery, orthopaedic surgeons of the spine deal with th…
364SS0200X	School Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
364SL0600X	Long-Term Care Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist

Related Payer Policy Updates

Specialty: Allergy/Clinical Immunology1 / 3

10 rows

Policy	Payer	Effective Date
Diagnosis of Idiopathic Environmental Intolerance	Oscar Health	2026-10-01
Allergen Testing	blue cross blue shield - louisiana	2026-09-15
Allergen Testing	Blue Cross Blue Shield - New Mexico	2026-09-04
Hereditary Angioedema - Ekterly	Cigna	2026-08-15
Omalizumab products (Xolair, Omlyclo) coverage	Premera Bluecross	2026-08-01
Omalizumab Products (Xolair, Omlyclo) coverage	Premera Bluecross	2026-08-01
Omalizumab Products	Premera Bluecross	2026-08-01
Allergy Testing	univerahealthcare	2026-07-16
EBGLYSS (lebrikizumab-lbkz) prior authorization for atopic dermatitis	Mississippi Division of Medicaid	2026-07-01
Xolair (omalizumab) (Subcutaneous) — Concomitant therapy restrictions and dosing guidance	eocco	2026-07-01

CPT 86803: Hepatitis C Antibody Immunoassay in Serum

CPT-86000-FEBRILE-AGGLUTININS-SEROLOGIC-TEST

CPT 86000: Febrile Agglutinins (Serologic Agglutination) Test

CPT-86001-ALLERGEN-SPECIFIC-IGG-LABORATORY-TEST

CPT 86001: Allergen-Specific IgG Assay, Technical Component

CPT-86003-ALLERGEN-SPECIFIC-IGE-ASSAY-TECHNICAL

CPT 86003: Allergen‑Specific IgE Assay Using Crude Allergen Extract

CPT-86005-MULTI-ALLERGEN-IGE-SCREENING-QUALITATIVE

CPT 86005: Multi-Allergen Allergen-Specific IgE Screening

CPT-86008-ALLERGEN-COMPONENT-SPECIFIC-IGE-ASSAY

CPT 86008: Allergen Component–Specific IgE Assay

CPT-86015-ANTI-ACTIN-SMOOTH-MUSCLE-ANTIBODY-ASMA

CPT 86015: Actin (Smooth Muscle) Antibody (ASMA) Immunoassay

CPT-86021-LEUKOCYTE-ANTIBODY-IDENTIFICATION-LAB-TECHNICAL

CPT 86021: Leukocyte Antibody Identification Laboratory Test

CPT-86022-PLATELET-ANTIBODY-IDENTIFICATION-TECHNICAL-TEST

CPT 86022: Platelet Antibody Detection and Identification

CPT-86023-PLATELET-ASSOCIATED-IMMUNOGLOBULIN-DETECTION

CPT 86023: Platelet-Associated Immunoglobulin Assay

Showing 1–10 of 199

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 86147: Cardiolipin (Antiphospholipid) Antibody Test

Sign up for cpt 86147 policy alerts

OpenPayer

CPT 86147: Cardiolipin (Antiphospholipid) Antibody Test

Sign up for cpt 86147 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

References

CPT 86147: Cardiolipin (Antiphospholipid) Antibody Test

Sign up for cpt 86147 policy alerts

CPT 86147: Cardiolipin (Antiphospholipid) Antibody Test

Sign up for cpt 86147 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

What does CPT 86147 describe?

In what clinical scenarios is 86147 commonly ordered?

What specimen collection and related CPT codes are associated with 86147?

How should 86147 be reported when multiple immunoglobulin classes are tested?

Which diagnoses commonly justify ordering cardiolipin antibody testing (86147)?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

What does CPT 86147 describe?

In what clinical scenarios is 86147 commonly ordered?

What specimen collection and related CPT codes are associated with 86147?

How should 86147 be reported when multiple immunoglobulin classes are tested?

Which diagnoses commonly justify ordering cardiolipin antibody testing (86147)?

References