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    OpenPayerBilling CodesHematology and Coagulation ProceduresCPT cpt-85613-russells-viper-venom-clotting-assay
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    CPT 85613: Russell’s Viper Venom Clotting Time Assay

    CPT code 85613 describes a laboratory assay in which a lab analyst measures the effect of specified concentrations of Russell’s viper venom on patient blood clotting time; this is a specialized coagulation/hematology diagnostic in vitro test typically performed in a clinical laboratory or hospital lab setting as a venom-induced clotting time assay for evaluation of coagulopathies or antivenom response.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult presenting to an emergency department or inpatient unit after an envenomation from a suspected Russell’s viper bite, or a patient referred to a hospital laboratory for evaluation of antivenom potency and neutralization studies. The treating team documents local tissue injury, systemic signs (coagulopathy, bleeding, hypotension), and orders laboratory testing to assess venom-induced consumption coagulopathy and to guide antivenom therapy. A blood specimen is collected by phlebotomy and delivered to a clinical or reference laboratory with hematology/coagulation capabilities. The laboratory analyst performs 85613 to measure the effect of graded concentrations of Russell’s viper venom on patient plasma clotting time, interpreting results in the context of fibrinogen levels, prothrombin time (PT), activated partial thromboplastin time (aPTT), platelet count, and clinical findings. Results are reported to the treating clinician to support decisions about antivenom dosing, monitoring for recurrent coagulopathy, and disposition. Typical site of service is a hospital laboratory or specialized reference laboratory; the service type is specialized coagulation/toxicology laboratory testing. The typical patient scenario includes urgent testing for an acute snakebite with suspected or confirmed Russell’s viper envenomation and for research or lot-release testing in public health or antivenom production settings.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    85025Blood count; automated differential WBC countPerformed concurrently to assess platelet count and white blood cells in envenomation workup prior to or alongside 85613.
    85610Prothrombin time test (PT) and INRCommonly ordered to evaluate coagulation status and complement the venom effect assay results.
    85730Thrombin timeUsed to evaluate fibrinogen function and detect fibrin degradation related to venom-induced coagulopathy.
    85384Fibrinogen activity assay (Clauss method)Directly assesses fibrinogen concentration and function, relevant when 85613 indicates venom-mediated fibrinogen consumption.
    86480Antivenin, equine origin, polyvalent, prescribing and administration documentation (not a laboratory test)Related to clinical management; laboratory results from 85613 inform antivenom administration and monitoring.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    2251C2600XCardiopulmonary Physical TherapistA licensed physical therapist, including but not limited to an individual who is a Board Certified Specialist in Cardiovascular & Pulmonary Physical T…
    156FX1202XOptometric TechnicianAn optometric technician assists optometrists by performing duties, including but not limited to, basic eye testing, diagnostic tests, and assistance …
    222Q00000XDevelopmental TherapistA Developmental Therapist is a person qualified by completion of an approved program in Developmental Therapy and where applicable credentialed by the…
    163WP0218XPediatric Oncology Registered NurseNursing Service Providers · Registered Nurse
    225B00000XPulmonary Function TechnologistAn individual who is trained and qualified to perform pulmonary diagnostic tests. In the course of conducting these tests, the Pulmonary Function Tec…
    261QR0401XComprehensive Outpatient Rehabilitation Facility (CORF)Ambulatory Health Care Facilities · Clinic/Center
    163WP0808XPsychiatric/Mental Health Registered NurseNursing Service Providers · Registered Nurse

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    A41.89Other specified sepsis
    A41.9Sepsis, unspecified organism
    B34.9Viral infection, unspecified
    D68.4Acquired coagulation factor deficiency
    D69.49Other primary thrombocytopenia
    D69.9Hemorrhagic condition, unspecified
    I82.90Acute embolism and thrombosis of unspecified vein
    I95.9Hypotension, unspecified
    L03.90Cellulitis, unspecified
    R58Hemorrhage, not elsewhere classified

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    CPT-85002-BLEEDING-TIME-TEST-LABORATORY

    CPT 85002: Bleeding Time Test, Technical Component

    CPT-85004-AUTOMATED-DIFFERENTIAL-WHITE-BLOOD-CELL-COUNT

    CPT 85004: Automated White Blood Cell Differential

    CPT-85007-MANUAL-DIFFERENTIAL-WHITE-BLOOD-CELL-COUNT

    CPT 85007: Manual Differential White Blood Cell Count

    CPT-85008-BLOOD-SMEAR-MORPHOLOGIC-REVIEW-NO-DIFFERENTIAL

    CPT 85008: Microscopic Blood Smear Examination, No Differential

    CPT-85009-MANUAL-WBC-COUNT-BUFFY-COAT

    CPT 85009: Manual White Blood Cell Count Using Buffy Coat

    CPT-85013-MICROHEMATOCRIT-TEST-LABORATORY-DIAGNOSTIC

    CPT 85013: Microhematocrit Test by Tube Centrifugation

    CPT-85014-HEMATOCRIT-VOLUME-PERCENT-RED-BLOOD-CELLS

    CPT 85014: Hematocrit (Volume Percent of Red Blood Cells)

    CPT-85018-HEMOGLOBIN-ASSAY-WHOLE-BLOOD

    CPT 85018: Hemoglobin Measurement in Whole Blood

    CPT-85025-COMPLETE-BLOOD-COUNT-CBC

    CPT 85025: Complete Blood Count (CBC)

    CPT-85027-COMPLETE-BLOOD-COUNT-HGB-HCT

    CPT 85027: Complete Blood Count with Hemoglobin and Hematocrit

    Showing 1–10 of 99

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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