Summary & Overview
CPT 85410: Alpha-2 Antiplasmin Assay, Laboratory Test
CPT code 85410 represents a laboratory assay for alpha-2 antiplasmin, a key inhibitor of fibrinolysis that helps maintain clot stability. Nationally, this test is used in the evaluation of bleeding and thrombotic disorders, monitoring of clotting function, and in some specialized coagulation workups. Accurate measurement of alpha-2 antiplasmin can affect diagnosis and management of fibrinolytic states and is relevant to hematology and coagulation services.
Key payers in typical analyses include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers can expect coverage and reimbursement benchmarks, common billing and coding considerations, and clinical context describing when the assay is ordered. The publication outlines typical sites of service and the laboratory service type, clarifies common modifiers and billing components where available, and summarizes implications for laboratory operations and billing workflows.
This overview is intended for a national audience of laboratory managers, billing professionals, and clinical teams seeking concise information on CPT code 85410, including how the test fits into diagnostic pathways and what payers commonly cover such testing.
Billing Code Overview
CPT code 85410 describes a laboratory assay measuring alpha-2 antiplasmin, a fibrinolytic inhibitor important in regulating clot stability. The test is performed by a laboratory analyst and provides a quantitative or qualitative assessment of alpha-2 antiplasmin activity or concentration.
Service type: Laboratory diagnostic test
Typical site of service: Clinical laboratory or hospital/medical laboratory
Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.
Clinical & Coding Specifications
Clinical Context
A 54-year-old male with a history of recurrent deep vein thrombosis (DVT) and abnormal bleeding following minor trauma is referred to the hematology laboratory for hemostasis evaluation. The clinician orders specialized fibrinolytic testing, including an alpha-2 antiplasmin assay, to assess inhibitors of fibrinolysis after routine coagulation studies (PT/INR, aPTT) and D-dimer remain inconclusive. A venous blood specimen is collected in a citrate tube and transported under chilled conditions to a reference coagulation laboratory. The laboratory analyst performs the 85410 test to measure alpha-2 antiplasmin antigen or functional activity using immunoassay or chromogenic methods. Results are reported in the electronic medical record and communicated to the ordering hematologist to guide diagnosis of hyperfibrinolysis, assessment of bleeding diatheses, or evaluation of therapeutic response to antifibrinolytic agents (for example, tranexamic acid) in perioperative or trauma settings.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
26 | Professional component | Use when only the professional interpretation or consultation portion is billed separately from the technical component. |
TC |