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    v1.0.28
    OpenPayerBilling CodesHematology and Coagulation ProceduresCPT cpt-85247-von-willebrand-factor-subtype-analysis
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    CPT 85247: von Willebrand Factor (VWF) Subtype Analysis

    CPT code 85247 describes a laboratory differential analysis of subtypes of coagulation factor VIII, also known as von Willebrand factor (VWF); this is a specialized immunohematology coagulation test typically processed by a clinical laboratory or hospital-based blood bank and reported as a diagnostic laboratory service for evaluation of bleeding disorders and VWF subtype characterization.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult or pediatric patient referred for laboratory evaluation of suspected von Willebrand disease (VWD) or factor VIII subtype abnormalities after clinical signs such as mucocutaneous bleeding, easy bruising, prolonged bleeding after surgery or dental procedures, or a family history of bleeding disorder. The usual workflow begins with the clinician ordering a bleeding profile that may include von Willebrand factor antigen, ristocetin cofactor activity, factor VIII activity, and multimer analysis or subtype differentiation represented by 85247. The specimen is collected via venipuncture into a sodium citrate tube, transported to a coagulation laboratory, centrifuged to obtain platelet-poor plasma, and tested by specialized assays to separate and quantify VWF/factor VIII subtypes. Results are interpreted by a laboratory hematologist or coagulation specialist and reported to the ordering clinician to guide diagnosis (e.g., type 1, 2A, 2B, 2M, 2N, or type 3 VWD), perioperative planning, or management decisions such as desmopressin responsiveness or factor replacement therapy. Typical sites of service include hospital outpatient laboratories, independent reference laboratories, and tertiary care center hematology labs. Common clinical indications include evaluation of abnormal prothrombin time/partial thromboplastin time in the context of bleeding, preoperative hemostatic risk assessment in patients with bleeding history, and family screening for inherited VWD.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    85730Thrombin time (TT)Performed in broader coagulation panels to assess fibrinogen function alongside VWF studies.
    85765Platelet function studies (aggregation)May be ordered concurrently to evaluate platelet-dependent bleeding disorders in patients with abnormal VWF function.
    85306Fibrinogen; functional (Clauss)Often included in a comprehensive hemostasis evaluation when assessing bleeding risk.
    85241Coagulation studies; factor activity assays (single factor)Factor VIII activity assays are commonly performed before or alongside VWF subtype analysis to correlate VWF-FVIII relationships.
    86140Ristocetin cofactor assayDirectly related functional assay of VWF activity frequently ordered with VWF multimer/subtype analysis.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    2080P0208XPediatric Infectious Diseases PhysicianA pediatrician trained to care for children in the diagnosis, treatment and prevention of infectious diseases. This specialist can apply specific know…
    2085R0202XDiagnostic Radiology PhysicianA radiologist who utilizes x-ray, radionuclides, ultrasound and electromagnetic radiation to diagnose and treat disease.
    103TH0100XHealth Service PsychologistA psychologist, certified/licensed at the independent practice level in his/her state, who is duly trained and experienced in the delivery of direct, …
    164X00000XLicensed Vocational NurseAn individual with post-high school vocational training and practical experience in the provision of nursing care at a level less than that required f…
    163WR1000XReproductive Endocrinology/Infertility Registered NurseNursing Service Providers · Registered Nurse
    364SC0200XCritical Care Medicine Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    2084N0600XClinical Neurophysiology PhysicianClinical Neurophysiology is a subspecialty with psychiatric or neurologic expertise in the diagnosis and management of central, peripheral, and autono…

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    CPT-85002-BLEEDING-TIME-TEST-LABORATORY

    CPT 85002: Bleeding Time Test, Technical Component

    CPT-85004-AUTOMATED-DIFFERENTIAL-WHITE-BLOOD-CELL-COUNT

    CPT 85004: Automated White Blood Cell Differential

    CPT-85007-MANUAL-DIFFERENTIAL-WHITE-BLOOD-CELL-COUNT

    CPT 85007: Manual Differential White Blood Cell Count

    CPT-85008-BLOOD-SMEAR-MORPHOLOGIC-REVIEW-NO-DIFFERENTIAL

    CPT 85008: Microscopic Blood Smear Examination, No Differential

    CPT-85009-MANUAL-WBC-COUNT-BUFFY-COAT

    CPT 85009: Manual White Blood Cell Count Using Buffy Coat

    CPT-85013-MICROHEMATOCRIT-TEST-LABORATORY-DIAGNOSTIC

    CPT 85013: Microhematocrit Test by Tube Centrifugation

    CPT-85014-HEMATOCRIT-VOLUME-PERCENT-RED-BLOOD-CELLS

    CPT 85014: Hematocrit (Volume Percent of Red Blood Cells)

    CPT-85018-HEMOGLOBIN-ASSAY-WHOLE-BLOOD

    CPT 85018: Hemoglobin Measurement in Whole Blood

    CPT-85025-COMPLETE-BLOOD-COUNT-CBC

    CPT 85025: Complete Blood Count (CBC)

    CPT-85027-COMPLETE-BLOOD-COUNT-HGB-HCT

    CPT 85027: Complete Blood Count with Hemoglobin and Hematocrit

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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