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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-82379-total-and-free-carnitine-testing
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    CPT 82379: Total and Free Carnitine Measurement

    CPT code 82379 describes laboratory measurement of total and free carnitine in serum, plasma, urine, or tissue specimens, a biochemical test used to evaluate carnitine status and disorders of fatty acid oxidation; the service is a clinical laboratory quantitative assay of carnitine and acylcarnitine fractions, typically performed in a clinical laboratory or reference laboratory and ordered following abnormal newborn screening or when metabolic evaluation is indicated.

    For related coverage guidance, see recent payer policy updates: Diabetic Supplies, Radiofrequency Ablation for Thyroid Nodules, Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A newborn infant born at a community hospital has a positive newborn screening blood spot for possible carnitine deficiency. The pediatrician orders quantitative serum testing for both total and free carnitine to confirm the screen. The infant is brought to the hospital outpatient laboratory or the hospital clinical chemistry laboratory where a phlebotomy technician collects a serum or plasma specimen. The specimen is sent to the biochemical genetics or hospital chemistry lab where a laboratory analyst performs analysis for total and free carnitine (CPT 82379). Results are reviewed by the pediatrician or a metabolic specialist; abnormal results prompt confirmatory testing, metabolic consult, nutritional counseling, and potential initiation of carnitine supplementation. Typical workflow steps: order placement in the electronic health record, specimen collection (serum, plasma, or urine), specimen processing and testing in the lab, result verification by laboratory personnel, and clinician review with documentation in the infant’s chart. Typical sites of service include hospital outpatient laboratory, ambulatory clinic laboratory, reference laboratory, and inpatient hospital laboratory when performed on hospitalized infants or patients under metabolic workup.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81025Urinalysis by dip stick or tablet reagent for bilirubin, glucose, hemoglobin, ketones, leukocytes, nitrite, pH, protein, specific gravity, urobilinogen, any number of these tests; non-automated, with microscopyPerformed when urine specimens are collected in parallel to evaluate renal function or to obtain urine specimen for carnitine measurement.
    82043Assay of carnitine (free and total) — note: alternative lab codes may be used depending on methodologyRelated biochemical assays and alternate lab code usage; used when reporting specific carnitine analyses depending on laboratory billing practice.
    82607Assay of serum ammoniaOften performed alongside carnitine testing in suspected metabolic disorders to assess for hyperammonemia.
    83970Assay of amino acids, quantitative, plasma (e.g., amino acid profile)Performed as part of a metabolic workup for inborn errors of metabolism that can accompany abnormal carnitine levels.
    81000Urinalysis, by dipstick or tablet reagent; automated, without microscopyUsed when automated urinalysis is obtained with urine specimens submitted for metabolic evaluation.
    80053Comprehensive metabolic panel (CMP)Often ordered concurrently to assess overall metabolic status and organ function during evaluation of possible metabolic disorders.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    2080P0202XPediatric Cardiology PhysicianA pediatric cardiologist provides comprehensive care to patients with cardiovascular problems. This specialist is skilled in selecting, performing and…
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    2085R0202XDiagnostic Radiology PhysicianA radiologist who utilizes x-ray, radionuclides, ultrasound and electromagnetic radiation to diagnose and treat disease.
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207QS0010XSports Medicine (Family Medicine) PhysicianA family medicine physician that is trained to be responsible for continuous care in the field of sports medicine, not only for the enhancement of hea…
    208G00000XThoracic Surgery (Cardiothoracic Vascular Surgery) PhysicianA thoracic surgeon provides the operative, perioperative and critical care of patients with pathologic conditions within the chest. Included is the su…
    261QV0200XVA Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    3336C0003XCommunity/Retail PharmacyA pharmacy where pharmacists store, prepare, and dispense medicinal preparations and/or prescriptions for a local patient population in accordance wit…

    Related ICD-10-CM Codes

    20 rows

    ICD-10-CM CodeDescription
    E10.9Type 1 diabetes mellitus without complications
    E11.9Type 2 diabetes mellitus without complications
    E45Retarded development following protein-calorie malnutrition
    E66.01Morbid (severe) obesity due to excess calories
    E66.9Obesity, unspecified
    E70.0Classical phenylketonuria
    E70.1Other hyperphenylalaninemias
    E78.5Hyperlipidemia, unspecified
    E83.39Other disorders of phosphorus metabolism
    E88.09Other disorders of plasma-protein metabolism, not elsewhere classified

    Showing 1–10 of 20

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Diabetic SuppliesCigna2026-10-15
    Radiofrequency Ablation for Thyroid NodulesCigna2026-10-15
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only)UnitedHealthcare2026-10-01
    Tzield (teplizumab-mzwv) CoverageUnitedHealthcare2026-10-01
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Indiana Only)UnitedHealthcare2026-10-01
    Medical Necessity Guidelines Insulin PumpsMass General Brigham Health Plan2026-10-01
    Medical Necessity Guidelines: Continuous Glucose MonitorsMass General Brigham Health Plan2026-10-01
    Continuous Glucose MonitoringAmbetter Nevada2026-10-01
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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