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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-84030-phenylalanine-quantitative-assay-phenylketonuria-screening
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    CPT 84030: Phenylalanine Assay, Blood Spot or Plasma

    CPT code 84030 describes a laboratory assay that detects and measures the amino acid phenylalanine, commonly performed on a filter-paper newborn blood spot card or on blood plasma; this test is a quantitative phenylalanine assay used for screening and monitoring phenylketonuria and related metabolic conditions, typically provided as a clinical laboratory service in hospital laboratories, independent diagnostic testing facilities, or public health screening programs.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing, Bone Turnover Markers Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A newborn infant born at a community hospital undergoes routine newborn metabolic screening. A heel-stick blood sample is collected onto a filter paper blood spot card within 24–48 hours of life and sent to the hospital laboratory. The lab analyst performs quantitative measurement of phenylalanine using a validated assay to screen for phenylketonuria (PKU) and other hyperphenylalaninemias. Results that exceed institutional cutoff values trigger reflex testing, confirmatory plasma phenylalanine measurement, and notification of the newborn nursery, pediatrician, and the state newborn screening program. For an older child or adult with developmental delay or suspected metabolic disorder, a clinician orders a plasma phenylalanine level; a phlebotomist obtains a venous blood sample, and the laboratory performs the 84030 assay to quantify phenylalanine concentration. Typical workflow steps include specimen collection, labeling and accessioning, analytical testing, result validation by a laboratory scientist, and result reporting to the ordering clinician and public health authorities when required.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80048Blood, amino acids; quantitative, multiple amino acidsSometimes ordered alongside 84030 when a broader amino acid panel is required to evaluate metabolic disorders.
    80055Chromosome analysis; postnatal (e.g., cytogenetic studies)Not directly related to routine PKU screening but may be performed in the diagnostic workup of developmental delay when genetic etiologies are considered.
    82607Phenylalanine; quantitativeAlternative or related code for plasma phenylalanine measurement in some billing systems; may be used depending on payer policies and specimen type.
    36415Collection of venous blood by venipunctureProcedure code for obtaining a plasma sample when 84030 is performed on plasma rather than filter paper.
    81025Urine pregnancy test (not relevant)Not typically related; included here only if pregnancy-related metabolic screening is indicated (rare).

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    231H00000XAudiologist(1) A specialist in evaluation, habilitation and rehabilitation of those whose communication disorders center in whole or in part in hearing function.…
    246ZI1000XMedical IllustratorNone
    125Q00000XOral Medicine DentistryOral Medicine is the specialty of dentistry responsible for the oral health care of medically complex patients and for the diagnosis and management of…
    261QH0100XHealth Service Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    2081N0008XNeuromuscular Medicine (Physical Medicine & Rehabilitation) PhysicianA physician who specializes in neuromuscular medicine possesses specialized knowledge in the science, clinical evaluation and management of these diso…

    Related ICD-10-CM Codes

    20 rows

    ICD-10-CM CodeDescription
    E10.9Type 1 diabetes mellitus without complications
    E11.9Type 2 diabetes mellitus without complications
    E70.0Classical phenylketonuria
    E70.1Other hyperphenylalaninemias
    E70.5Disorders of tryptophan metabolism
    E70.9Disorder of aromatic amino-acid metabolism, unspecified
    E78.5Hyperlipidemia, unspecified
    F84.0Autistic disorder
    G31.84Mild cognitive impairment of uncertain or unknown etiology
    P04.0Newborn affected by maternal anesthesia and analgesia in pregnancy, labor and delivery

    Showing 1–10 of 20

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Diabetes Mellitus Testing — Coverage CriteriaOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01
    Thyroid Disease Testingblue cross blue shield - louisiana2026-09-15
    Thyroid Disease TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Parathyroid Hormone, Phosphorous, Calcium and Magnesium TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Testosterone laboratory testing and managementPremera Bluecross2026-09-04

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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