CPT code 83088 describes a laboratory assay that measures histamine levels in whole blood, serum, plasma, or urine to evaluate histamine release from mast cells and basophils; the service is a clinical laboratory test typically performed in a hospital laboratory, outpatient laboratory, or reference lab using blood or urine specimens for diagnostic evaluation of conditions involving mast cell activation or allergic responses.

For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing, Bone Turnover Markers Testing.