CPT code 82652 represents a laboratory assay for vitamin D, 1,25-dihydroxy, the hormonally active form of vitamin D that stimulates intestinal calcium absorption. This specialized biochemical test is used in clinical evaluations of calcium-phosphate disorders, complex metabolic bone disease, and in monitoring certain renal or parathyroid conditions. Nationally, accurate measurement of 1,25-dihydroxy vitamin D supports diagnosis and management of disorders where active vitamin D levels, rather than total or 25-hydroxy vitamin D, are clinically relevant.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an overview of payer coverage patterns and common billing practices, clinical context distinguishing this assay from other vitamin D tests, and operational benchmarks where available. The publication also outlines typical sites of service and the role of the assay in care pathways for metabolic bone disease and renal/endocrine evaluations.

This summary is intended for clinicians, laboratory managers, and billing professionals seeking concise national-level context on CPT code 82652, including what the test measures, where it is performed, and the aspects of coverage and billing that commonly affect laboratory utilization.