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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-82088-aldosterone-quantitative-assay-serum-plasma-urine
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    CPT 82088: Aldosterone Quantitative Assay

    Commercial payers pay $74 on average nationally for this procedure.

    CPT code 82088 describes a quantitative laboratory assay to measure aldosterone concentration, typically performed on serum, plasma, or urine to evaluate suspected primary or secondary hyperaldosteronism; this is a clinical laboratory service (endocrine/metabolic testing) commonly ordered from outpatient clinics or hospital laboratories and performed in a clinical laboratory or hospital lab setting.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing, Bone Turnover Markers Testing.

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    National Reimbursement Benchmarks

    For CPT 82088 the average commercial benchmark (BUCA) sits at $73.90, positioning national commercial reimbursement near the mid-range among large payers. Blue Cross Blue Shield exhibits the highest mean at $100.50 and the largest spread between the 25th and 75th percentiles ($61.60 to $122.60), while Aetna and Cigna have lower means of $35.10 and $45.10 respectively. UnitedHealth Group’s mean is $35.40, with a notably low median of $24.50 versus its mean, suggesting skew toward higher outliers.

    Measuring dispersion as P75 minus P25, Blue Cross Blue Shield is the widest with a spread of $60.10, indicating greater regional or contractual variability; BUCA’s interquartile spread is $44.40, reflecting moderate commercial variability around the $73.90 average. The tightest spreads are with UnitedHealth Group ($19.70) and Cigna ($34.10), implying relatively more consistency in negotiated commercial rates for those payers.

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    National Payer Mean Reimbursement Rates

    State Reimbursement Rates

    State: Alaska1 / 51

    Rate by payer

    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old patient with treatment-resistant hypertension and unexplained hypokalemia is referred by an internal medicine physician for endocrine evaluation. The clinician suspects primary hyperaldosteronism due to persistent elevated blood pressure despite three antihypertensive agents and low serum potassium on prior basic metabolic testing. The provider orders a quantitative aldosterone measurement to determine circulating aldosterone levels, typically on a morning serum sample after appropriate medication adjustments or posture/sodium preparation per local protocol. The specimen is collected in an ambulatory laboratory or hospital phlebotomy station and sent to the clinical medical laboratory for analysis. Results are reviewed by the ordering clinician (family medicine or internal medicine) and interpreted alongside plasma renin activity or direct renin concentration and other metabolic lab tests to establish a diagnosis and guide further imaging or referral to endocrinology.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80053Comprehensive metabolic panelProvides baseline electrolytes, renal function, and metabolic data; used alongside aldosterone testing to assess hypokalemia and renal status.
    82310

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    291U00000XClinical Medical Laboratory(1) A clinical laboratory is a facility for the biological, microbiological, serological, chemical, immunohematological, hematological, biophysical, c…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    364SI0800XInformatics Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    283Q00000XPsychiatric HospitalAn organization including a physical plant and personnel that provides multidisciplinary diagnostic and treatment mental health services to patients r…
    213EP0504XPublic Medicine PodiatristPodiatric Medicine & Surgery Service Providers · Podiatrist
    221700000XArt Therapist(1) An individual who uses art to achieve the therapeutic goals of symptom relief, emotional integration, and recovery from or adjustment to illness o…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …

    Related ICD-10-CM Codes

    31 rows

    ICD-10-CM CodeDescription
    E03.9Hypothyroidism, unspecified
    E11.65Type 2 diabetes mellitus with hyperglycemia
    E16.2Hypoglycemia, unspecified
    E24.9Cushing's syndrome, unspecified
    E26.1Secondary hyperaldosteronism
    E26.9Hyperaldosteronism, unspecified
    E27.0Other adrenocortical overactivity
    E27.1Primary adrenocortical insufficiency
    E27.8Other specified disorders of adrenal gland
    E83.50Unspecified disorder of calcium metabolism

    Showing 1–10 of 31

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Diabetes Mellitus Testing — Coverage CriteriaOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01
    Thyroid Disease Testingblue cross blue shield - louisiana2026-09-15
    Thyroid Disease TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Parathyroid Hormone, Phosphorous, Calcium and Magnesium TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Testosterone laboratory testing and managementPremera Bluecross2026-09-04

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

    Calcium; total
    Often ordered with metabolic panels to evaluate electrolyte disturbances that can accompany endocrine disorders.
    82247Bilirubin; totalPart of liver function assessment when liver disease is in the differential or comorbid conditions are present.
    84153Prostate specific antigen (PSA); totalUnrelated to aldosterone measurement clinically; listed as an associated laboratory test that may be ordered in routine male health maintenance.
    84460Alanine aminotransferase (ALT) (SGPT)Ordered to evaluate hepatic injury or chronic liver disease when liver-related ICD-10 codes are present in the medical record.