CPT code 81515 describes a laboratory service in which a vaginal fluid specimen undergoes real-time PCR amplification for specified bacterial DNA markers and an algorithmic analysis combining patient data and test results to report a positive or negative result for a high likelihood of bacterial vaginosis; the service is a molecular diagnostic test with algorithmic interpretation typically performed as a laboratory-based (clinical laboratory) service on vaginal specimens and may additionally report detection of organisms such as Trichomonas vaginalis and Candida species.

For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.