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    v1.0.31
    OpenPayerBilling CodesGenetic Analysis ProceduresCPT cpt-81315-pml-raralpha-fusion-detection-quantification
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    CPT 81315: PML/RARα (t(15;17)) Fusion Gene Detection

    CPT code 81315 describes a molecular pathology laboratory test that detects and quantifies the PML/RARα (promyelocytic leukemia/retinoic acid receptor alpha, t(15;17)) fusion resulting from common breakpoints (including introns 3 and 6); service type: targeted molecular diagnostic assay for fusion gene detection; typical site of service: clinical molecular diagnostics laboratory or hospital molecular pathology lab performing technical testing.

    For related coverage guidance, see recent payer policy updates: Minimal Residual Disease (MRD) Testing for Cancer, Biomarker Testing Mandate, Prenatal (Fetal) Diagnostic Testing.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 47-year-old patient presents with symptoms suggestive of acute promyelocytic leukemia (APL) including fatigue, easy bruising, and thrombocytopenia on complete blood count. The hematologist orders molecular testing to detect the PML/RARalpha fusion transcript associated with the t(15;17) translocation. A peripheral blood or bone marrow specimen is collected in an appropriate transport tube and sent to a clinical molecular diagnostics laboratory. The lab analyst performs a targeted nucleic acid test (such as reverse transcription PCR or quantitative PCR) to evaluate the presence and/or amount of the PML/RARalpha fusion resulting from common breakpoints in introns 3 and 6. Results are interpreted and reported to the ordering hematologist/oncologist and included in the medical record to guide diagnosis, induction therapy decisions (for example, use of all-trans retinoic acid), risk stratification, and minimal residual disease monitoring during and after therapy. Typical sites of service include hospital inpatient laboratories, outpatient hospital laboratories, and independent reference molecular diagnostic laboratories.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81206BCR-ABL1 (eg, Philadelphia chromosome) transcript analysis, quantitative or qualitative, each transcriptUsed in evaluation of other fusion transcripts in suspected leukemias; performed in parallel or as part of a broader molecular leukemia panel
    81207BCR-ABL1 (eg, Philadelphia chromosome) transcript analysis, by quantitative methodQuantitative monitoring for therapies in other leukemia subtypes; analogous methodology to 81315
    81479Unlisted molecular pathology procedureUsed when a specific molecular test lacks a unique code; not typically required for PML/RARalpha since 81315 exists
    0000UExample molecular assay codes (placeholder proprietary assay)Proprietary or platform-specific molecular assays used by reference labs for PML/RARalpha detection; reported when applicable
    88185Flow cytometry, antigen marker(s) (per specimen)Performed adjunctively in the diagnostic workup of acute leukemias alongside molecular testing

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RG0100X
    261QR0400X
    246QL0901X
    156FX1700X
    207RM1200X
    208100000X
    156FC0800X
    207RA0401X

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Minimal Residual Disease (MRD) Testing for Cancerregence2027-01-01
    Biomarker Testing MandateBlue Cross Blue Shield - Rhode Island2027-01-01
    Prenatal (Fetal) Diagnostic TestingBlue Cross Blue Shield - Rhode Island2027-01-01
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Polygenic Risk ScoreBlue Cross Blue Shield - Rhode Island2026-12-01
    Gene Expression Profiling for Cutaneous MelanomaBlue Cross Blue Shield - Rhode Island2026-12-01
    Genetic Testing for Macular Degenerationregence2026-11-01
    Pharmacogenetic Panel Testing (for Ohio Only)Colorado Rocky Mountain Health Plans2026-11-01

    Related Codes

    CPT-81105-HPA-1-PLATELET-ANTIGEN-1-GENOTYPING-ITGB3-CD61

    CPT 81105: HPA-1 (ITGB3/CD61) Genotyping, Technical Component

    CPT-81106-HPA-2-T145M-GENETIC-ALLELE-ANALYSIS

    CPT 81106: HPA-2 (T145M) Platelet Antigen Genotyping

    CPT-81107-HPA-3-GENETIC-ANALYSIS-TECHNICAL-COMPONENT

    CPT 81107: HPA‑3 (I843S) Platelet Antigen Genotyping

    CPT-81108-HPA-4-R143Q-GENOTYPING

    CPT 81108: HPA-4 (R143Q) Genotyping

    CPT-81109-HPA-5-K505E-GENETIC-ANALYSIS

    CPT 81109: HPA-5 (K505E) Genotyping Test

    CPT-81110-HPA-6-R489Q-GENOTYPING

    CPT 81110: HPA-6 (R489Q) Genotyping, Technical Component

    CPT-81111-HPA-9-V837M-ALLELE-ANALYSIS

    CPT 81111: HPA-9 (V837M) Genotyping, Technical Test

    CPT-81112-HPA-15-GENETIC-ANALYSIS-S682Y

    CPT 81112: HPA-15 (S682Y) Platelet Antigen Genotyping

    CPT-81120-IDH1-MOLECULAR-DIAGNOSTIC-TEST

    CPT 81120: IDH1 Mutation Detection, Technical Component

    CPT-81121-IDH2-MOLECULAR-DIAGNOSTIC-TEST

    CPT 81121: IDH2 Mutation Detection, Technical Component

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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