CPT code 81265 denotes laboratory testing for Short Tandem Repeat (STR) markers used to compare genetic similarity between a patient and another specimen. STR analysis is central to identity verification, relationship testing, forensic comparison, and certain legal or investigational scenarios. As a technical laboratory service, this code reflects the lab-based analytic component rather than clinical interpretation or counseling.

Key payers included in the coverage discussion are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a national-level overview of the code’s clinical context and service setting, coverage considerations by major payers, and common billing elements. The publication summarizes benchmarks where available, highlights policy and coding guidance relevant to laboratory STR testing, and outlines operational points such as typical site of service and the technical nature of the procedure.

This summary is intended for billing managers, laboratory administrators, and policy analysts who need a concise reference to CPT code 81265 — what it represents, why it matters in clinical and legal testing pathways, and the types of payer policies and documentation topics that commonly accompany STR laboratory services. Data not available in the input is noted where applicable.