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    v1.0.30
    OpenPayerBilling CodesGenetic Analysis ProceduresCPT cpt-81110-hpa-6-r489q-genotyping
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    CPT 81110: HPA-6 (R489Q) Genotyping, Technical Component

    CPT code 81110 describes a laboratory genotyping test that detects the two common alleles of Human Platelet Antigen 6 (HPA–6 / R489Q) from a specimen such as blood or amniotic fluid; service type is molecular/diagnostic laboratory testing and the typical site of service is a clinical laboratory or hospital lab where the technical laboratory analysis is performed.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A pregnant patient undergoes targeted platelet antigen genotyping when there is concern for maternal alloimmunization to fetal platelet antigens or when planning transfusion support. Typical scenarios include a woman with a prior pregnancy complicated by neonatal alloimmune thrombocytopenia (NAIT), a history of fetal or neonatal intracranial hemorrhage, or an obstetric history of unexplained fetal thrombocytopenia. A specimen (peripheral blood or amniotic fluid) is sent to a molecular diagnostics laboratory for analysis of Human Platelet Antigen 6 (HPA-6, also called R489Q) alleles. The laboratory technologist performs DNA extraction, PCR-based allele discrimination or sequencing, and reports genotype results (e.g., HPA-6a/HPA-6a, HPA-6a/HPA-6b, HPA-6b/HPA-6b). Results inform obstetric management (risk assessment for NAIT), selection of antigen-negative platelet units if transfusion is needed, and counseling of parents regarding recurrence risk. Typical site of service is a hospital-based or independent clinical molecular diagnostics laboratory; specimens are collected from outpatient clinics, inpatient obstetric units, or maternal-fetal medicine practices.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81162HLA class I typing, sequence-specific oligonucleotide probe (SSOP) or sequence-based typing (SBT)Performed when broader platelet or HLA compatibility is needed for platelet transfusion planning; may be ordered alongside HPA typing.
    81479Unlisted molecular pathology procedureUsed for molecular tests that do not have a specific CPT; rarely used if HPA-6 testing is performed by a method without an assigned code.
    82948Blood count; platelet countCommonly performed in newborns or pregnant patients to document thrombocytopenia associated with alloimmune platelet disease.
    87491Infectious agent detection by nucleic acid (e.g., PCR), single organismNot directly related but may be performed in parallel testing workflows in molecular labs; typically unrelated.
    36415Collection of venous blood by venipunctureSpecimen collection code commonly used when peripheral blood is drawn for HPA genotyping.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    207Q00000X
    207L00000X
    208100000X
    2084P0800X
    106E00000X
    207XS0114X
    2471V0105X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    D56.9Thalassemia, unspecified
    D66Hereditary factor VIII deficiency
    D67Hereditary factor IX deficiency
    D68.9Coagulation defect, unspecified
    D69.2Other nonthrombocytopenic purpura
    D69.3Immune thrombocytopenic purpura
    D69.49Other primary thrombocytopenia
    D69.51Posttransfusion purpura
    D69.59Other secondary thrombocytopenia
    D69.6Thrombocytopenia, unspecified

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-81105-HPA-1-PLATELET-ANTIGEN-1-GENOTYPING-ITGB3-CD61

    CPT 81105: HPA-1 (ITGB3/CD61) Genotyping, Technical Component

    CPT-81106-HPA-2-T145M-GENETIC-ALLELE-ANALYSIS

    CPT 81106: HPA-2 (T145M) Platelet Antigen Genotyping

    CPT-81107-HPA-3-GENETIC-ANALYSIS-TECHNICAL-COMPONENT

    CPT 81107: HPA‑3 (I843S) Platelet Antigen Genotyping

    CPT-81108-HPA-4-R143Q-GENOTYPING

    CPT 81108: HPA-4 (R143Q) Genotyping

    CPT-81109-HPA-5-K505E-GENETIC-ANALYSIS

    CPT 81109: HPA-5 (K505E) Genotyping Test

    CPT-81111-HPA-9-V837M-ALLELE-ANALYSIS

    CPT 81111: HPA-9 (V837M) Genotyping, Technical Test

    CPT-81112-HPA-15-GENETIC-ANALYSIS-S682Y

    CPT 81112: HPA-15 (S682Y) Platelet Antigen Genotyping

    CPT-81120-IDH1-MOLECULAR-DIAGNOSTIC-TEST

    CPT 81120: IDH1 Mutation Detection, Technical Component

    CPT-81121-IDH2-MOLECULAR-DIAGNOSTIC-TEST

    CPT 81121: IDH2 Mutation Detection, Technical Component

    CPT-81161-DMD-GENE-DELETION-DUPLICATION-ANALYSIS

    CPT 81161: Dystrophin (DMD) Gene Deletion/Duplication Analysis

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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