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    v1.0.30
    OpenPayerBilling CodesClinical Pathology ConsultationsCPT cpt-80505-pathology-consultation-high-complexity-41-60-minutes
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    CPT 80505: Pathology Consultation, High Complexity

    Medicare pays $97 on average nationally for this procedure.

    CPT code 80505 describes a pathologist consultation for a highly complex clinical problem requiring a high level of medical judgment; the service includes a comprehensive review of the patient history and medical records and is time-based when 41–60 minutes of consultation are documented on the consultation date, typically provided as a specialized pathology consultation service in an outpatient clinic, hospital, or laboratory setting.

    For related coverage guidance, see recent payer policy updates: Long-Acting Injectable Antiretroviral Agents for HIV, B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old hospitalized patient with complex, undifferentiated hematologic abnormalities is referred by the treating physician to the pathology service for expert interpretation. The pathologist performs a consultation that includes a comprehensive review of the patient history, prior laboratory results, imaging, medication list, and prior pathology slides or reports. The consult addresses a highly complex clinical problem — for example, discordant bone marrow morphology and flow cytometry, unusual neoplastic cell populations on peripheral smear, or ambiguous immunohistochemical patterns on a biopsy — requiring advanced diagnostic judgment. The consultation visit on the documented date requires sustained evaluation and interpretation totaling 41–60 minutes of documented effort, or the pathologist documents that the consultation was requested to assist in clarifying prior diagnostic test findings. The typical workflow includes chart review, review of prior pathology slides and ancillary test results, formulation of differential diagnoses, discussion with the requesting clinician, and preparation of a written consultative report. Typical sites of service are inpatient hospitals, academic medical centers, and reference pathology laboratories providing tertiary-level diagnostic consultations.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80505Pathologist consultation for a highly complex clinical problem; includes comprehensive review of history and records or 41–60 minutes documented on the consultation date.Primary code describing the consultative service performed by the pathologist for complex diagnostic problems.
    88305Level IV surgical pathology, gross and microscopic examinationOften performed before or in conjunction with a consult when additional slide review or resection specimen interpretation is needed.
    88342Immunohistochemistry (per specimen; each antibody)Commonly ordered as adjunct testing when immunophenotypic characterization is required to clarify a complex diagnosis.
    85210Peripheral blood smear, interpretationMay precede or accompany the consult when peripheral smear review is part of the diagnostic evaluation.
    88184Flow cytometry immunophenotyping, up to 4 markers, per specimenFrequently used in hematopathology consults to characterize cell populations and support the consultative opinion.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    207L00000X
    208100000X
    207K00000X
    133VN1005X
    261QX0200X
    246R00000X
    207ZP0101X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C50.911Malignant neoplasm of unspecified site of right female breast
    C61Malignant neoplasm of prostate
    D37.9Neoplasm of uncertain behavior of digestive organ, unspecified
    E11.9Type 2 diabetes mellitus without complications
    E66.9Obesity, unspecified
    E78.5Hyperlipidemia, unspecified
    F33.1Major depressive disorder, recurrent, moderate
    G43.909Migraine, unspecified, not intractable, without status migrainosus
    I10Essential (primary) hypertension

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    CPT-80503-PATHOLOGY-CONSULTATION-LIMITED-STRAIGHTFORWARD

    CPT 80503: Pathologist Consultation, Straightforward Medical Judgment

    CPT-80504-PATHOLOGY-CONSULTATION-MODERATE-COMPLEXITY

    CPT 80504: Pathology Consultation, Moderate Complexity

    CPT-80506-PATHOLOGY-CONSULTATION-ADD-ON-EXTENDED-TIME

    CPT 80506: Pathology Consultation, Additional 30-Minute Unit

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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