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    v1.0.30
    OpenPayerBilling CodesClinical Pathology ConsultationsCPT cpt-80504-pathology-consultation-moderate-complexity
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    CPT 80504: Pathology Consultation, Moderate Complexity

    Medicare pays $53 on average nationally for this procedure.

    CPT code 80504 describes a pathologist consultation performed at the request of a physician or other qualified healthcare provider for a moderately complex clinical problem that requires a moderate level of medical judgment; the service includes review of patient history and medical records and is typically billed when 21–40 minutes are documented on the consultation date, representing a pathology consultation service usually provided in an outpatient clinic, hospital, or laboratory setting.

    For related coverage guidance, see recent payer policy updates: Long-Acting Injectable Antiretroviral Agents for HIV, B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays.

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old patient with a recent core needle liver biopsy has a pathology specimen with atypical findings. The treating hepatologist requests a pathology consultation to help interpret immunohistochemical stains, review the patient’s prior biopsy reports, imaging summaries, and clinical history, and to provide an expert diagnostic impression. The pathologist reviews the medical record, examines the slide set, correlates prior results, and documents 25 minutes of moderate-complexity medical judgment on the consultation date. The service is furnished at an outpatient pathology service within an ambulatory surgery center or hospital outpatient department, and may also occur as an interdepartmental consultation documented in the inpatient chart. Typical workflow includes chart retrieval, slide review, discussion with the requesting physician (phone or electronic), and issuance of a formal consultation addendum in the pathology report.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    88305Level IV surgical pathology, gross and microscopic examinationCommon primary code for review of biopsy slides; consultation may supplement or follow this service.
    88342Immunohistochemistry (per specimen, per antibody stain)Often performed to clarify diagnosis and referenced in consultations for additional interpretation.
    80502Pathology consultation; limited complexity (this is an adjacent consult code)Used for consultations of lower complexity; 80504 is for moderate complexity and is performed when greater judgment/time is required.
    80307Drug assay; qualitative (e.g., toxicology panels)Occasionally correlated in consultations when clinical toxicology or medication effects factor into pathology interpretation.
    G0463Hospital outpatient clinic visit for assessment and management of a patientMay appear in the clinical workflow when the consulting pathologist documents findings in the hospital outpatient chart.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207R00000X
    207L00000X
    208000000X
    207X00000X
    261QA1903X
    207XX0801X
    208C00000X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B20Human immunodeficiency virus [HIV] disease
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C50.912Malignant neoplasm of unspecified site of left female breast
    C61Malignant neoplasm of prostate
    D50.9Iron deficiency anemia, unspecified
    D64.9Anemia, unspecified
    E11.9Type 2 diabetes mellitus without complications
    E78.5Hyperlipidemia, unspecified
    F32.9Major depressive disorder, single episode, unspecified

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    CPT-80503-PATHOLOGY-CONSULTATION-LIMITED-STRAIGHTFORWARD

    CPT 80503: Pathologist Consultation, Straightforward Medical Judgment

    CPT-80505-PATHOLOGY-CONSULTATION-HIGH-COMPLEXITY-41-60-MINUTES

    CPT 80505: Pathology Consultation, High Complexity

    CPT-80506-PATHOLOGY-CONSULTATION-ADD-ON-EXTENDED-TIME

    CPT 80506: Pathology Consultation, Additional 30-Minute Unit

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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