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    v1.0.30
    OpenPayerBilling CodesTherapeutic Drug AssaysCPT cpt-80373-tramadol-toxicology-assay
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    CPT 80373: Tramadol Detection/Quantification in Patient Specimen

    CPT code 80373 describes a laboratory test that measures the amount of or detects the presence of tramadol, a centrally acting opioid analgesic, in a patient specimen; this is a toxicology/drug assay service typically performed by a clinical laboratory using urine or other biological specimens and reported as a discrete lab procedure for drug monitoring or toxicology screening in outpatient, inpatient, or reference laboratory settings.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A 42-year-old patient on chronic pain management presents for an outpatient urine or serum drug test to confirm tramadol use and detect possible misuse or diversion. The clinician orders a targeted tramadol assay when the patient reports increased pain, requests dose escalation, or when pill count/observed behavior raises concern for nonadherence. A specimen (urine or blood) is collected in a clinic laboratory or sent to a reference lab. The laboratory analyst performs qualitative or quantitative testing to detect the presence of tramadol and/or its major metabolite(s). Results are reported to the ordering clinician and used to guide therapy decisions, verify adherence to a controlled-substance agreement, or support occupational or forensic testing. Typical site of service: outpatient clinic, hospital laboratory, or independent diagnostic laboratory. Service type: laboratory drug/toxicology test specific to tramadol detection/quantification using immunoassay and/or confirmatory methods such as gas chromatography-mass spectrometry (GC-MS) or liquid chromatography–tandem mass spectrometry (LC-MS/MS).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80373Tramadol detection; laboratory assay for presence or quantitation of tramadol in specimenPrimary code describing the laboratory measurement of tramadol in a patient specimen.
    80305Drug test, presumptive, any number of drug classes; any number of specimens, through immunoassay, per date of serviceCommonly used as an initial screening test before specific tramadol confirmation; may trigger 80373 for tramadol-specific analysis.
    80307Drug confirmation test, any number of drug classes; confirmatory testing using methods such as GC-MS or LC-MS/MSPerformed when a presumptive screen is positive or when quantitative confirmation of tramadol is required; follows or accompanies 80373 for definitive identification/quantitation.
    36415Collection of venous blood by venipunctureSpecimen collection code when blood is used for tramadol quantitation.
    81002Urinalysis, non-automated, without microscopy, non-qualitative; collection and handlingRepresents specimen handling/urine collection steps when urine is the specimen for tramadol testing.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    363L00000X
    208D00000X
    207Q00000X
    193200000X
    2085N0904X
    2086S0127X
    207VC0200X
    207QS1201X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-80143-ACETAMINOPHEN-QUANTITATIVE-SERUM-ASSAY

    CPT 80143: Acetaminophen Quantitative Assay

    CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80145: Adalimumab Quantitative Drug Level Assay

    CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80150: Amikacin Quantitative Serum Level

    CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

    CPT 80151: Amiodarone Quantitative Drug Level Assay

    CPT-80155-CAFFEINE-LEVEL-TESTING

    CPT 80155: Caffeine Level Quantification

    CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

    CPT 80156: Carbamazepine Total Level (Serum)

    CPT-80157-FREE-CARBAMAZEPINE-ASSAY

    CPT 80157: Free Carbamazepine Quantitative Assay

    CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

    CPT 80158: Cyclosporine Quantitation, Laboratory

    CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80159: Clozapine Level Measurement

    CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

    CPT 80161: Carbamazepine 10,11-Epoxide Level, Quantitative

    Showing 1–10 of 87

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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