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    v1.0.28
    OpenPayerBilling CodesTherapeutic Drug AssaysCPT cpt-80352-synthetic-cannabinoids-panel-seven-or-more
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    CPT 80352: Multi-Analyte Synthetic Cannabinoid Detection

    CPT code 80352 describes a laboratory procedure in which the analyst measures or detects the presence of seven or more synthetic cannabinoids in a patient specimen; this is a multi-analyte toxicology test typically performed as a laboratory toxicology assay on biological specimens such as urine or blood in a clinical laboratory or reference lab setting for clinical, forensic, or substance-use monitoring purposes.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only).

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient scenario involves an adult or adolescent who presents to an emergency department, outpatient clinic, occupational health program, substance use disorder program, correctional facility, or occupational drug testing laboratory with suspected use of synthetic cannabinoids (commonly known as K2, Spice, or synthetic marijuana) after acute behavioral changes, altered mental status, agitation, hallucinations, cardiovascular symptoms (tachycardia, hypertension), or as part of a workplace or forensic drug screen. A clinician orders comprehensive toxicology testing when standard urine or serum drug screens are negative or when there is clinical suspicion for newer synthetic cannabinoid analogs.

    The clinical workflow begins with specimen collection (urine, serum, or plasma) and labeling, with proper chain-of-custody if forensically required. The specimen is sent to a clinical laboratory that performs targeted mass spectrometry or immunoassay panels configured to detect multiple synthetic cannabinoid compounds. The laboratory analyst performs qualitative or quantitative testing that identifies seven or more synthetic cannabinoid analytes, documents method and limits of detection, and reports results to the ordering provider. Results inform clinical management (supportive care, psychiatric evaluation, toxicology consultation) and may be used for public health surveillance, workplace compliance, or legal proceedings. Turnaround time varies from hours (stat) to days (routine) depending on assay complexity and instrumentation availability.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80351Drug screen, qualitative; multiple drug classes by immunoassay with instrumented chemistry analyzers (e.g., toxicology screen)Often performed as an initial broad screen; 80352 follows when specific synthetic cannabinoid panels are required or when more analytes are detected.
    80354Drug test, definitive, each specimen; any method, but definitive (e.g., mass spectrometry), for non-quantitative confirmatory testing of drugs of abuseUsed for definitive confirmation of specific synthetic cannabinoid analytes detected in the screening process; may accompany or follow 80352 depending on laboratory workflow.
    80360Drug testing, definitive, quantitative, each drug class; includes mass spectrometry for quantitationEmployed when quantitation of specific synthetic cannabinoid concentrations is clinically necessary for management or legal purposes.
    G0480Drug screen, definitive, chromatographic method, each specimen (Medicare-specific G-code)Applicable in workflows where Medicare billing requires G-codes for definitive toxicology testing and to report confirmatory chromatographic tests alongside 80352.
    81002Urinalysis, non-automated, without microscopyPerformed at specimen collection as part of initial assessment and documentation; supports interpretation of urine-based synthetic cannabinoid testing.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    292200000XDental LaboratoryA commercial laboratory specializing in the construction of dental appliances that conform to a dentist's specifications including the construction of…
    281P00000XChronic Disease Hospital(1) A hospital including a physical plant and personnel that provides multidisciplinary diagnosis and treatment for diseases that have one or more of …
    211D00000XPodiatric AssistantAn individual who assists a podiatrist in tasks, such as exposing and developing x-rays; taking and recording patient histories; assisting in biomecha…
    322D00000XEmotionally Disturbed Childrens' Residential Treatment FacilityA residential facility that provides habilitation services and other care and treatment to children diagnosed with mental health illness, behavioral i…
    207QA0000XAdolescent Medicine (Family Medicine) PhysicianA family medicine physician with multidisciplinary training in the unique physical, psychological and social characteristics of adolescents and their …

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Chimeric Antigen Receptor (CAR) T-Cell TherapyColorado Rocky Mountain Health Plans2026-08-01
    Allogeneic Hematopoietic Progenitor Cell TherapyAmbetter Georgia2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)UnitedHealthcare2026-08-01
    Reblozyl (luspatercept-aamt) Medical Benefit Drug PolicyUnitedHealthcare2026-08-01

    Related Codes

    CPT-80143-ACETAMINOPHEN-QUANTITATIVE-SERUM-ASSAY

    CPT 80143: Acetaminophen Quantitative Assay

    CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80145: Adalimumab Quantitative Drug Level Assay

    CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80150: Amikacin Quantitative Serum Level

    CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

    CPT 80151: Amiodarone Quantitative Drug Level Assay

    CPT-80155-CAFFEINE-LEVEL-TESTING

    CPT 80155: Caffeine Level Quantification

    CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

    CPT 80156: Carbamazepine Total Level (Serum)

    CPT-80157-FREE-CARBAMAZEPINE-ASSAY

    CPT 80157: Free Carbamazepine Quantitative Assay

    CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

    CPT 80158: Cyclosporine Quantitation, Laboratory

    CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

    CPT 80159: Clozapine Level Measurement

    CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

    CPT 80161: Carbamazepine 10,11-Epoxide Level, Quantitative

    Showing 1–10 of 87

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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