CPT 80337: Multiple Tricyclic and Cyclic Antidepressant Detection

CPT code 80337 describes a laboratory test that measures the amount of or detects the presence of six or more tricyclic and other cyclic antidepressant medications in a patient specimen, a toxicology/therapeutic drug monitoring service typically performed by a clinical laboratory using blood or urine specimens and usually provided in an inpatient, outpatient, or reference laboratory setting.

For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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Clinical & Coding Specifications

Clinical Context

A 42-year-old patient with a history of major depressive disorder and suspected medication nonadherence is evaluated after a change in symptoms and possible polypharmacy concerns. The treating psychiatrist orders a comprehensive urine or serum toxicology panel to detect and quantify tricyclic and other cyclic antidepressants to guide medication management and safety monitoring. The specimen is collected in an outpatient behavioral health clinic or hospital laboratory, labeled and sent to the clinical chemistry/toxicology laboratory. A laboratory analyst performs a multi-analyte assay capable of measuring the presence or amount of six or more tricyclic and other cyclic antidepressants; results are reviewed by the ordering clinician to confirm adherence, identify potential drug interactions or toxicity, and adjust therapy as needed. Typical sites of service include outpatient behavioral health clinics, hospital outpatient labs, emergency departments (for acute presentation or overdose evaluation), and inpatient psychiatric units.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80336`	Drug assay, presumptive, any number of drug classes; combined immunoassay screens that do not confirm individual analytes	Frequently performed as an initial rapid screen prior to definitive multi-analyte confirmation such as `80337`.
`80339`	Drug confirmation test, definitive, each specimen; chromatographic with mass spectrometry (e.g., GC/MS, LC/MS)	Often used when confirmatory testing for specific antidepressant analytes is required after the multi-analyte measurement in `80337`.
`81002`	Urinalysis, by dipstick or tablet reagent for bilirubin, glucose, hemoglobin, etc.; without microscopy	May be performed at specimen collection to assess specimen integrity or concurrent urinary findings.
`36415`	Collection of venous blood by venipuncture	Commonly billed when blood (serum/plasma) is the specimen type for measuring antidepressant levels.
`99000`	Handling and/or conveyance of specimen for transfer from clinic to laboratory	Used when special handling or courier services are required to transport specimens for `80337`.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
2084P0800X	Psychiatry Physician	A Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
261QM2500X	Medical Specialty Clinic/Center	An entity, facility, or distinct part of a facility providing diagnostic, treatment, and prescriptive services related to a specific area of medical s…
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
207XP3100X	Pediatric Orthopaedic Surgery Physician	An orthopedic surgeon who has additional training and experience in diagnosing, treating and managing musculoskeletal problems in infants, children an…
246ZE0600X	Electroneurodiagnostic Specialist/Technologist	Technologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Other
261QI0500X	Infusion Therapy Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center

Related Payer Policy Updates

Specialty: Hematology/Oncology1 / 2

4 rows

Policy	Payer	Effective Date
Epithelial Cell Cytology in Breast Cancer Risk Assessment	Oscar Health	2026-10-01
Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)	UnitedHealthcare	2026-08-01
Antibody-Drug Conjugates	Premera Bluecross	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)	UnitedHealthcare	2026-08-01

CPT 80143: Acetaminophen Quantitative Assay

CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80145: Adalimumab Quantitative Drug Level Assay

CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80150: Amikacin Quantitative Serum Level

CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

CPT 80151: Amiodarone Quantitative Drug Level Assay

CPT-80155-CAFFEINE-LEVEL-TESTING

CPT 80155: Caffeine Level Quantification

CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

CPT 80156: Carbamazepine Total Level (Serum)

CPT-80157-FREE-CARBAMAZEPINE-ASSAY

CPT 80157: Free Carbamazepine Quantitative Assay

CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

CPT 80158: Cyclosporine Quantitation, Laboratory

CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80159: Clozapine Level Measurement

CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

CPT 80161: Carbamazepine 10,11-Epoxide Level, Quantitative

Showing 1–10 of 87

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80336`	Drug assay, presumptive, any number of drug classes; combined immunoassay screens that do not confirm individual analytes	Frequently performed as an initial rapid screen prior to definitive multi-analyte confirmation such as `80337`.
`80339`	Drug confirmation test, definitive, each specimen; chromatographic with mass spectrometry (e.g., GC/MS, LC/MS)	Often used when confirmatory testing for specific antidepressant analytes is required after the multi-analyte measurement in `80337`.
`81002`	Urinalysis, by dipstick or tablet reagent for bilirubin, glucose, hemoglobin, etc.; without microscopy	May be performed at specimen collection to assess specimen integrity or concurrent urinary findings.
`36415`	Collection of venous blood by venipuncture	Commonly billed when blood (serum/plasma) is the specimen type for measuring antidepressant levels.
`99000`	Handling and/or conveyance of specimen for transfer from clinic to laboratory	Used when special handling or courier services are required to transport specimens for `80337`.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
2084P0800X	Psychiatry Physician	A Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
261QM2500X	Medical Specialty Clinic/Center	An entity, facility, or distinct part of a facility providing diagnostic, treatment, and prescriptive services related to a specific area of medical s…
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
207XP3100X	Pediatric Orthopaedic Surgery Physician	An orthopedic surgeon who has additional training and experience in diagnosing, treating and managing musculoskeletal problems in infants, children an…
246ZE0600X	Electroneurodiagnostic Specialist/Technologist	Technologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Other
261QI0500X	Infusion Therapy Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center

Related Payer Policy Updates

Specialty: Hematology/Oncology1 / 2

4 rows

Policy	Payer	Effective Date
Epithelial Cell Cytology in Breast Cancer Risk Assessment	Oscar Health	2026-10-01
Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)	UnitedHealthcare	2026-08-01
Antibody-Drug Conjugates	Premera Bluecross	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)	UnitedHealthcare	2026-08-01

CPT 80143: Acetaminophen Quantitative Assay

CPT-80145-ADALIMUMAB-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80145: Adalimumab Quantitative Drug Level Assay

CPT-80150-AMIKACIN-QUANTITATIVE-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80150: Amikacin Quantitative Serum Level

CPT-80151-AMIODARONE-QUANTITATIVE-SERUM-ASSAY

CPT 80151: Amiodarone Quantitative Drug Level Assay

CPT-80155-CAFFEINE-LEVEL-TESTING

CPT 80155: Caffeine Level Quantification

CPT-80156-CARBAMAZEPINE-TOTAL-LEVEL-LAB-ASSAY

CPT 80156: Carbamazepine Total Level (Serum)

CPT-80157-FREE-CARBAMAZEPINE-ASSAY

CPT 80157: Free Carbamazepine Quantitative Assay

CPT-80158-CYCLOSPORINE-QUANTITATIVE-ASSAY-LAB

CPT 80158: Cyclosporine Quantitation, Laboratory

CPT-80159-CLOZAPINE-LEVEL-ASSAY-THERAPEUTIC-DRUG-MONITORING

CPT 80159: Clozapine Level Measurement

CPT-80161-CARBAMAZEPINE-EPOXIDE-QUANTITATIVE-ASSAY

CPT 80161: Carbamazepine 10,11-Epoxide Level, Quantitative

Showing 1–10 of 87

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

CPT 80337: Multiple Tricyclic and Cyclic Antidepressant Detection

Sign up for cpt 80337 policy alerts

CPT 80337: Multiple Tricyclic and Cyclic Antidepressant Detection

Sign up for cpt 80337 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

References

CPT 80337: Multiple Tricyclic and Cyclic Antidepressant Detection

Sign up for cpt 80337 policy alerts

CPT 80337: Multiple Tricyclic and Cyclic Antidepressant Detection

Sign up for cpt 80337 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

What is CPT 80337 and when is it used?

Where is the 80337 test performed and where is the specimen commonly collected?

Which billing modifiers are applicable to CPT 80337?

What are common related CPT codes and services associated with 80337?

Which diagnoses or clinical scenarios support ordering CPT 80337?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Payer Policy Updates

Related Codes

What is CPT 80337 and when is it used?

Where is the 80337 test performed and where is the specimen commonly collected?

Which billing modifiers are applicable to CPT 80337?

What are common related CPT codes and services associated with 80337?

Which diagnoses or clinical scenarios support ordering CPT 80337?

References