Summary & Overview
CPT 80337: Multi-Analyte Assay for Tricyclic and Cyclic Antidepressants
CPT code 80337 represents a laboratory toxicology assay that detects or quantifies six or more tricyclic and other cyclic antidepressant medications in a patient specimen. Nationally, this testing is important for psychiatric medication management, monitoring therapeutic adherence, forensic assessment, and safety surveillance when multiple cyclic antidepressants are involved. The code denotes a complex, multi-analyte assay typically performed by clinical or hospital laboratories and billed separately from specimen collection and interpretation.
Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an overview of the clinical context for multi-analyte antidepressant testing, expected sites of service, and how this CPT code fits into laboratory service lines. The publication also outlines typical billing considerations, common modifiers used with laboratory services, and where to look for policy or coverage guidance. Practical benchmarks, utilization patterns, and payer-specific coverage nuances are summarized to support coding accuracy and billing workflow decisions at a national level.
Data not available in the input for associated taxonomies, specific ICD-10 diagnoses, related codes, and payer-specific reimbursement rates.
Billing Code Overview
CPT code 80337 describes a laboratory assay in which the analyst measures the amount of, or detects the presence of, six or more tricyclic and other cyclic antidepressant medications in a patient specimen. This service is a multi-analyte toxicology screen focused on psychiatric medications used to monitor therapy, assess adherence, or detect potential misuse.
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Service type: Clinical laboratory toxicology assay for multiple tricyclic and cyclic antidepressants
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Typical site of service: Clinical laboratory or hospital laboratory; specimen collection commonly occurs in outpatient clinics, psychiatric practices, emergency departments, or inpatient hospital settings
Clinical & Coding Specifications
Clinical Context
A 42-year-old patient with a history of major depressive disorder and suspected medication nonadherence is evaluated after a change in symptoms and possible polypharmacy concerns. The treating psychiatrist orders a comprehensive urine or serum toxicology panel to detect and quantify tricyclic and other cyclic antidepressants to guide medication management and safety monitoring. The specimen is collected in an outpatient behavioral health clinic or hospital laboratory, labeled and sent to the clinical chemistry/toxicology laboratory. A laboratory analyst performs a multi-analyte assay capable of measuring the presence or amount of six or more tricyclic and other cyclic antidepressants; results are reviewed by the ordering clinician to confirm adherence, identify potential drug interactions or toxicity, and adjust therapy as needed. Typical sites of service include outpatient behavioral health clinics, hospital outpatient labs, emergency departments (for acute presentation or overdose evaluation), and inpatient psychiatric units.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
26 | Professional component | Use when billing provider reports only the professional interpretation component of the laboratory test if applicable under local billing rules. |
52 |