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    v1.0.30
    OpenPayerBilling CodesPresumptive Drug Class Screening ProceduresCPT cpt-80307-presumptive-instrumented-drug-screen
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    CPT 80307: Presumptive Drug Test by Instrumented Analyzer

    Commercial payers pay $137 on average nationally for this procedure.

    CPT code 80307 describes a presumptive drug test performed by a laboratory analyst using instrumented chemistry analyzers to screen for one or more drug classes on a single date; service type: laboratory toxicology screening; typical site of service: clinical laboratory or hospital laboratory collection and testing setting.

    For related coverage guidance, see recent payer policy updates: Intraosseous Basivertebral Nerve Ablation for Child Health Plus (CHP) and Essential Plan (EP) Members, Acupuncture Services Payment Policy, Drug Testing in Pain Management and Substance Use Disorder.

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    National Reimbursement Benchmarks

    National commercial reimbursement for CPT 80307 clusters around BUCA’s average commercial rate of $136.60, with substantial differences among individual payers. Blue Cross Blue Shield displays the highest mean and a high median near $195.10, while Aetna and Cigna both show means near $61–$63 and medians in the low $50s. UnitedHealth Group’s mean is lower at $51.20 with a median of $37.30. These differences indicate a stratified market where BUCA sits between the higher Blue Cross Blue Shield levels and the lower Aetna/Cigna/UnitedHealth Group segment.

    Dispersion measured by the interquartile range (P75–P25) highlights variation in contract pricing: Blue Cross Blue Shield’s IQR is $109.50 (P75 $242.80 minus P25 $141.30), the widest, while UnitedHealth Group is the tightest with an IQR of $33.20 (P75 $62.10 minus P25 $26.90). Cigna and BUCA show moderate dispersion at $50.70 and $76.30 respectively, and Aetna’s IQR is $24.00, indicating relatively concentrated pricing for Aetna and UnitedHealth Group compared with Blue Cross Blue Shield.

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    National Payer Mean Reimbursement Rates

    State Reimbursement Rates

    State: Alaska1 / 51

    Rate by payer

    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult presenting to an emergency department or outpatient clinic with altered mental status, suspected drug ingestion, possible overdose, or as part of workplace or pre-procedural screening. A clinician orders a presumptive urine or serum drug screen performed by the laboratory using instrumented chemistry analyzers to rapidly screen for multiple drug classes on a single date. The workflow: clinician documents indication and collects a specimen, the specimen is accessioned in the lab, an automated immunoassay or chemistry analyzer panel is run under the supervision of a laboratory analyst, results are verified and routed to the ordering clinician. Positive or unexpected presumptive results frequently trigger confirmatory testing (e.g., gas chromatography-mass spectrometry) and clinician notification for patient management decisions such as naloxone administration, observation, or consultation with toxicology.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80307Drug screen, presumptive, multiple drug classes, instrumented chemistry analyzers; per dateThis is the primary service: automated presumptive screening of multiple drug classes on a single date.
    80306Drug screen, presumptive, single drug class, instrumented chemistry analyzers

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    95Modifier 95 indicates that a service was provided via synchronous, real‑time audio‑video telehealth rather than in‑person. Per CMS, AAPC and professional associations, append modifier 95 to claim…- Use modifier 95 to indicate a service was furnished via synchronous, real‑time audiovisual telehealth (a live audio‑video conference between patient and provider) rather than in‑person. - Pair…
    99Modifier 99 is a placeholder modifier used when more modifiers apply to a single procedure than the claim form or electronic field allows. The AMA classifies it under Provider Services and Ambulatory…- Use CPT modifier -99 when more modifiers apply to a single procedure line than the claim form or payer field allows (CMS/Noridian: when more than four modifiers are needed); append modifier 99 on…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207L00000X
    3336C0002X
    247000000X
    363LC0200X
    208G00000X
    204F00000X
    2278G0305X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    F10.129Alcohol abuse with intoxication, unspecified
    F10.20Alcohol dependence, uncomplicated
    F11.10Opioid abuse, uncomplicated
    F11.20Opioid dependence, uncomplicated
    F11.21Opioid dependence, in remission
    F12.10Cannabis abuse, uncomplicated
    F12.20Cannabis dependence, uncomplicated
    F14.10Cocaine abuse, uncomplicated
    F14.20Cocaine dependence, uncomplicated
    F15.10Other stimulant abuse, uncomplicated

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Pain Management1 / 2

    10 rows

    PolicyPayerEffective Date
    Intraosseous Basivertebral Nerve Ablation for Child Health Plus (CHP) and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Acupuncture Services Payment Policyfallon_community_health_plan_inc2026-12-01
    Drug Testing in Pain Management and Substance Use Disorderbcbsvermont2026-11-01
    Lysis of Epidural Adhesionsexcellus_health_plan_inc2026-10-15
    Intradiscal Proceduresexcellus_health_plan_inc2026-10-15
    Radiofrequency Facet and Sacroiliac Joint Ablation/ Denervationuniverahealthcare2026-10-15
    Facet Joint Injections/ Medial Branch Blocksuniverahealthcare2026-10-15
    Lysis of Epidural Adhesions (Epidural Adhesiolysis)univerahealthcare2026-10-15
    Epidural Steroid Injections / Selective Nerve Root Block (SNRB)univerahealthcare2026-10-15
    Prolotherapyuniverahealthcare2026-10-15

    Related Codes

    CPT-80305-PRESUMPTIVE-DRUG-TEST-VISUAL-READ

    CPT 80305: Presumptive Drug Test, Visual Read

    CPT-80306-PRESUMPTIVE-DRUG-TESTING-IMMUNOASSAY

    CPT 80306: Presumptive Drug Screen, Instrument-Read

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    Used when only a single drug class is screened rather than multiple classes.
    80320Confirmation of drug(s) using definitive quantitative methods (e.g., GC-MS, LC-MS/MS)Performed after a positive or clinically discordant presumptive screen to provide definitive, confirmatory identification and quantitation.
    81025Urinalysis; non-automated, without microscopyCommon accompanying specimen evaluation when a urine specimen is submitted for drug screening.
    36415Collection of venous blood by venipunctureUsed if serum or plasma is collected for drug screening or confirmatory testing.