CPT 80307: Presumptive Drug Test by Instrumented Analyzer

Commercial payers pay $137 on average nationally for this procedure.

CPT code 80307 describes a presumptive drug test performed by a laboratory analyst using instrumented chemistry analyzers to screen for one or more drug classes on a single date; service type: laboratory toxicology screening; typical site of service: clinical laboratory or hospital laboratory collection and testing setting.

Customize your policy alerts

Sign up for cpt 80307 policy alerts

Get alerted when payer policies referencing 80307 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

National Reimbursement Benchmarks

National commercial reimbursement for CPT 80307 clusters around BUCA’s average commercial rate of $136.60, with substantial differences among individual payers. Blue Cross Blue Shield displays the highest mean and a high median near $195.10, while Aetna and Cigna both show means near $61–$63 and medians in the low $50s. UnitedHealth Group’s mean is lower at $51.20 with a median of $37.30. These differences indicate a stratified market where BUCA sits between the higher Blue Cross Blue Shield levels and the lower Aetna/Cigna/UnitedHealth Group segment.

Dispersion measured by the interquartile range (P75–P25) highlights variation in contract pricing: Blue Cross Blue Shield’s IQR is $109.50 (P75 $242.80 minus P25 $141.30), the widest, while UnitedHealth Group is the tightest with an IQR of $33.20 (P75 $62.10 minus P25 $26.90). Cigna and BUCA show moderate dispersion at $50.70 and $76.30 respectively, and Aetna’s IQR is $24.00, indicating relatively concentrated pricing for Aetna and UnitedHealth Group compared with Blue Cross Blue Shield.

Explore openpayer tools

View all tools

CPT 80307: Presumptive Drug Test by Instrumented Analyzer

Commercial payers pay $137 on average nationally for this procedure.

Customize your policy alerts

Sign up for cpt 80307 policy alerts

Get alerted when payer policies referencing 80307 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

National Reimbursement Benchmarks

National Payer Mean Reimbursement Rates

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult presenting to an emergency department or outpatient clinic with altered mental status, suspected drug ingestion, possible overdose, or as part of workplace or pre-procedural screening. A clinician orders a presumptive urine or serum drug screen performed by the laboratory using instrumented chemistry analyzers to rapidly screen for multiple drug classes on a single date. The workflow: clinician documents indication and collects a specimen, the specimen is accessioned in the lab, an automated immunoassay or chemistry analyzer panel is run under the supervision of a laboratory analyst, results are verified and routed to the ordering clinician. Positive or unexpected presumptive results frequently trigger confirmatory testing (e.g., gas chromatography-mass spectrometry) and clinician notification for patient management decisions such as naloxone administration, observation, or consultation with toxicology.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80307`	Drug screen, presumptive, multiple drug classes, instrumented chemistry analyzers; per date	This is the primary service: automated presumptive screening of multiple drug classes on a single date.
`80306`	Drug screen, presumptive, single drug class, instrumented chemistry analyzers	Used when only a single drug class is screened rather than multiple classes.
`80320`	Confirmation of drug(s) using definitive quantitative methods (e.g., GC-MS, LC-MS/MS)	Performed after a positive or clinically discordant presumptive screen to provide definitive, confirmatory identification and quantitation.
`81025`	Urinalysis; non-automated, without microscopy	Common accompanying specimen evaluation when a urine specimen is submitted for drug screening.
`36415`	Collection of venous blood by venipuncture	Used if serum or plasma is collected for drug screening or confirmatory testing.

Related Modifiers

8 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
76	Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…	- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
77	Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…	- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
95	Modifier 95 indicates that a service was provided via synchronous, real‑time audio‑video telehealth rather than in‑person. Per CMS, AAPC and professional associations, append modifier 95 to claim…	- Use modifier 95 to indicate a service was furnished via synchronous, real‑time audiovisual telehealth (a live audio‑video conference between patient and provider) rather than in‑person. - Pair…
99	Modifier 99 is a placeholder modifier used when more modifiers apply to a single procedure than the claim form or electronic field allows. The AMA classifies it under Provider Services and Ambulatory…	- Use CPT modifier -99 when more modifiers apply to a single procedure line than the claim form or payer field allows (CMS/Noridian: when more than four modifiers are needed); append modifier 99 on…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
3336C0002X	Clinic Pharmacy	A pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
247000000X	Health Information Technician	Preferred term for an Accredited Record Technician who is an individual with an associate's degree from an accredited college or independent study pro…
363LC0200X	Critical Care Medicine Nurse Practitioner	Physician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
208G00000X	Thoracic Surgery (Cardiothoracic Vascular Surgery) Physician	A thoracic surgeon provides the operative, perioperative and critical care of patients with pathologic conditions within the chest. Included is the su…
204F00000X	Transplant Surgery Physician	A surgeon who specializes in transplant surgery.
2278G0305X	Geriatric Care Certified Respiratory Therapist	Care of older patients who have age and/or disease related decremental pulmonary changes. Diagnosis and treatment is very important for this group si…

Related ICD-10-CM Codes

28 rows

ICD-10-CM Code	Description
F10.129	Alcohol abuse with intoxication, unspecified
F10.20	Alcohol dependence, uncomplicated
F11.10	Opioid abuse, uncomplicated
F11.20	Opioid dependence, uncomplicated
F11.21	Opioid dependence, in remission
F12.10	Cannabis abuse, uncomplicated
F12.20	Cannabis dependence, uncomplicated
F14.10	Cocaine abuse, uncomplicated
F14.20	Cocaine dependence, uncomplicated
F15.10	Other stimulant abuse, uncomplicated

Showing 1–10 of 28

CPT 80305: Presumptive Drug Test, Visual Read

CPT-80306-PRESUMPTIVE-DRUG-TESTING-IMMUNOASSAY

CPT 80306: Presumptive Drug Screen, Instrument-Read

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80307`	Drug screen, presumptive, multiple drug classes, instrumented chemistry analyzers; per date	This is the primary service: automated presumptive screening of multiple drug classes on a single date.
`80306`	Drug screen, presumptive, single drug class, instrumented chemistry analyzers	Used when only a single drug class is screened rather than multiple classes.
`80320`	Confirmation of drug(s) using definitive quantitative methods (e.g., GC-MS, LC-MS/MS)	Performed after a positive or clinically discordant presumptive screen to provide definitive, confirmatory identification and quantitation.
`81025`	Urinalysis; non-automated, without microscopy	Common accompanying specimen evaluation when a urine specimen is submitted for drug screening.
`36415`	Collection of venous blood by venipuncture	Used if serum or plasma is collected for drug screening or confirmatory testing.

Related Modifiers

8 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
76	Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…	- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
77	Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…	- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
95	Modifier 95 indicates that a service was provided via synchronous, real‑time audio‑video telehealth rather than in‑person. Per CMS, AAPC and professional associations, append modifier 95 to claim…	- Use modifier 95 to indicate a service was furnished via synchronous, real‑time audiovisual telehealth (a live audio‑video conference between patient and provider) rather than in‑person. - Pair…
99	Modifier 99 is a placeholder modifier used when more modifiers apply to a single procedure than the claim form or electronic field allows. The AMA classifies it under Provider Services and Ambulatory…	- Use CPT modifier -99 when more modifiers apply to a single procedure line than the claim form or payer field allows (CMS/Noridian: when more than four modifiers are needed); append modifier 99 on…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
3336C0002X	Clinic Pharmacy	A pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
247000000X	Health Information Technician	Preferred term for an Accredited Record Technician who is an individual with an associate's degree from an accredited college or independent study pro…
363LC0200X	Critical Care Medicine Nurse Practitioner	Physician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
208G00000X	Thoracic Surgery (Cardiothoracic Vascular Surgery) Physician	A thoracic surgeon provides the operative, perioperative and critical care of patients with pathologic conditions within the chest. Included is the su…
204F00000X	Transplant Surgery Physician	A surgeon who specializes in transplant surgery.
2278G0305X	Geriatric Care Certified Respiratory Therapist	Care of older patients who have age and/or disease related decremental pulmonary changes. Diagnosis and treatment is very important for this group si…

Related ICD-10-CM Codes

28 rows

ICD-10-CM Code	Description
F10.129	Alcohol abuse with intoxication, unspecified
F10.20	Alcohol dependence, uncomplicated
F11.10	Opioid abuse, uncomplicated
F11.20	Opioid dependence, uncomplicated
F11.21	Opioid dependence, in remission
F12.10	Cannabis abuse, uncomplicated
F12.20	Cannabis dependence, uncomplicated
F14.10	Cocaine abuse, uncomplicated
F14.20	Cocaine dependence, uncomplicated
F15.10	Other stimulant abuse, uncomplicated

Showing 1–10 of 28

CPT 80305: Presumptive Drug Test, Visual Read

CPT-80306-PRESUMPTIVE-DRUG-TESTING-IMMUNOASSAY

CPT 80306: Presumptive Drug Screen, Instrument-Read

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 80307: Presumptive Drug Test by Instrumented Analyzer

Sign up for cpt 80307 policy alerts

National Reimbursement Benchmarks

OpenPayer

CPT 80307: Presumptive Drug Test by Instrumented Analyzer

Sign up for cpt 80307 policy alerts

National Reimbursement Benchmarks

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

CPT 80307: Presumptive Drug Test by Instrumented Analyzer

Sign up for cpt 80307 policy alerts

National Reimbursement Benchmarks

CPT 80307: Presumptive Drug Test by Instrumented Analyzer

Sign up for cpt 80307 policy alerts

National Reimbursement Benchmarks

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does CPT 80307 represent and when is it used?

In what clinical settings and workflows is 80307 commonly performed?

How do reimbursement rates for CPT 80307 vary across payers nationally?

Which modifiers are commonly used with CPT 80307 according to the coding specifications?

What other CPT codes are commonly reported alongside 80307?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does CPT 80307 represent and when is it used?

In what clinical settings and workflows is 80307 commonly performed?

How do reimbursement rates for CPT 80307 vary across payers nationally?

Which modifiers are commonly used with CPT 80307 according to the coding specifications?

What other CPT codes are commonly reported alongside 80307?

References