CPT 80306: Presumptive Drug Screen, Instrument-Read

Commercial payers pay $30 on average nationally for this procedure.

CPT code 80306 describes a presumptive drug screening performed by a laboratory analyst using instrument-assisted direct optical observation (commonly immunoassay) to screen one or more drug classes on a single date; service type: presumptive toxicology/drug screen (instrument-read immunoassay); typical site of service: clinical laboratory or outpatient laboratory collection site where instrument-based immunoassay testing is performed.

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National Reimbursement Benchmarks

Across national commercial payers, BUCA (average commercial) centers near $30.4 for CPT 80306, offering a useful midpoint for comparison. Blue Cross Blue Shield displays the highest mean at $42.5 and a wide interquartile spread ($44.10 p75 minus $37.80 p25 = $6.30), while Cigna’s mean of $16.4 and Aetna’s mean of $12.6 sit well below BUCA. UnitedHealth Group and Aetna have lower medians ($10.3 and $13.0 respectively) compared with Blue Cross Blue Shield and Cigna.

Dispersion varies meaningfully by payer: Blue Cross Blue Shield’s IQR equals $6.30, the widest among payers, indicating greater regional or contractual variability. UnitedHealth Group shows a tighter IQR of $9.00 (p75 $17.10 minus p25 $7.20 = $9.90) and Cigna’s IQR is $12.40 (p75 $21.40 minus p25 $9.00 = $12.40), while Aetna’s IQR is $6.00 (p75 $16.00 minus p25 $10.00 = $6.00), making Aetna one of the tighter distributions around its median.

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CPT 80306: Presumptive Drug Screen, Instrument-Read

Commercial payers pay $30 on average nationally for this procedure.

Customize your policy alerts

Sign up for cpt 80306 policy alerts

Get alerted when payer policies referencing 80306 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

National Reimbursement Benchmarks

National Payer Mean Reimbursement Rates

Clinical & Coding Specifications

Clinical Context

A 32-year-old patient presents to an outpatient addiction medicine clinic for routine monitoring during a medication-assisted treatment program. A urine sample is collected and sent to the clinic laboratory. The lab analyst performs a presumptive instrument-read urine drug screen using an immunoassay panel that simultaneously screens multiple drug classes (e.g., opioids, benzodiazepines, amphetamines, cocaine metabolites, THC). Results are reviewed by the clinic and documented in the medical record the same day; any presumptive positives may prompt confirmatory testing by a reference laboratory. Typical workflow: sample collection at point of care or sent to lab → accessioning and labeling → instrument-assisted immunoassay presumptive screen (80306) → result entry and clinician review → reflex confirmatory testing if required → clinical follow-up and documentation.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80307`	Drug confirmation, any number of drug classes; chromatographic method (eg, GC, LC), includes immunoassay when performed, and confirmation by mass spectrometry or other definitive methods	Used when a presumptive positive on `80306` is confirmed by definitive laboratory methods
`81002`	Urinalysis, non-automated, without microscopy	Often performed alongside `80306` to evaluate urine appearance, concentration, and basic chemistry
`81003`	Urinalysis, non-automated, with microscopy	Performed when microscopic evaluation is clinically indicated after abnormal screening results
`36415`	Collection of venous blood by venipuncture	May be used if blood testing is required for confirmatory or additional toxicology assays
`G0480`	Drug testing, definitive, any number of drug classes, separate procedure (Medicare)	Alternative definitive testing code used in some payer workflows when confirmation is performed

Related Modifiers

7 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
3336C0002X	Clinic Pharmacy	A pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
385HR2050X	Respite Care Camp	A camping facility that provides specialized respite care to individuals requiring enhanced services to enable them to remain in the community, (e.g.,…
261QR0400X	Rehabilitation Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center
261QM0801X	Mental Health Clinic/Center (Including Community Mental Health Center)	Ambulatory Health Care Facilities · Clinic/Center
152WP0200X	Pediatric Optometrist	Optometrists who work in Pediatrics are concerned with the prevention, development, diagnosis, and treatment of visual problems in children.

Related ICD-10-CM Codes

24 rows

ICD-10-CM Code	Description
F10.10	Alcohol abuse, uncomplicated
F10.20	Alcohol dependence, uncomplicated
F11.10	Opioid abuse, uncomplicated
F11.20	Opioid dependence, uncomplicated
F12.10	Cannabis abuse, uncomplicated
F12.20	Cannabis dependence, uncomplicated
F13.20	Sedative, hypnotic or anxiolytic dependence, uncomplicated
F14.20	Cocaine dependence, uncomplicated
F17.200	Nicotine dependence, unspecified, uncomplicated
F17.210	Nicotine dependence, cigarettes, uncomplicated

Showing 1–10 of 24

CPT 80305: Presumptive Drug Test, Visual Read

CPT-80307-PRESUMPTIVE-INSTRUMENTED-DRUG-SCREEN

CPT 80307: Presumptive Drug Test by Instrumented Analyzer

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80307`	Drug confirmation, any number of drug classes; chromatographic method (eg, GC, LC), includes immunoassay when performed, and confirmation by mass spectrometry or other definitive methods	Used when a presumptive positive on `80306` is confirmed by definitive laboratory methods
`81002`	Urinalysis, non-automated, without microscopy	Often performed alongside `80306` to evaluate urine appearance, concentration, and basic chemistry
`81003`	Urinalysis, non-automated, with microscopy	Performed when microscopic evaluation is clinically indicated after abnormal screening results
`36415`	Collection of venous blood by venipuncture	May be used if blood testing is required for confirmatory or additional toxicology assays
`G0480`	Drug testing, definitive, any number of drug classes, separate procedure (Medicare)	Alternative definitive testing code used in some payer workflows when confirmation is performed

Related Modifiers

7 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
208D00000X	General Practice Physician	A physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
3336C0002X	Clinic Pharmacy	A pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
385HR2050X	Respite Care Camp	A camping facility that provides specialized respite care to individuals requiring enhanced services to enable them to remain in the community, (e.g.,…
261QR0400X	Rehabilitation Clinic/Center	Ambulatory Health Care Facilities · Clinic/Center
261QM0801X	Mental Health Clinic/Center (Including Community Mental Health Center)	Ambulatory Health Care Facilities · Clinic/Center
152WP0200X	Pediatric Optometrist	Optometrists who work in Pediatrics are concerned with the prevention, development, diagnosis, and treatment of visual problems in children.

Related ICD-10-CM Codes

24 rows

ICD-10-CM Code	Description
F10.10	Alcohol abuse, uncomplicated
F10.20	Alcohol dependence, uncomplicated
F11.10	Opioid abuse, uncomplicated
F11.20	Opioid dependence, uncomplicated
F12.10	Cannabis abuse, uncomplicated
F12.20	Cannabis dependence, uncomplicated
F13.20	Sedative, hypnotic or anxiolytic dependence, uncomplicated
F14.20	Cocaine dependence, uncomplicated
F17.200	Nicotine dependence, unspecified, uncomplicated
F17.210	Nicotine dependence, cigarettes, uncomplicated

Showing 1–10 of 24

CPT 80305: Presumptive Drug Test, Visual Read

CPT-80307-PRESUMPTIVE-INSTRUMENTED-DRUG-SCREEN

CPT 80307: Presumptive Drug Test by Instrumented Analyzer

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 80306: Presumptive Drug Screen, Instrument-Read

Sign up for cpt 80306 policy alerts

National Reimbursement Benchmarks

OpenPayer

CPT 80306: Presumptive Drug Screen, Instrument-Read

Sign up for cpt 80306 policy alerts

National Reimbursement Benchmarks

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

CPT 80306: Presumptive Drug Screen, Instrument-Read

Sign up for cpt 80306 policy alerts

National Reimbursement Benchmarks

CPT 80306: Presumptive Drug Screen, Instrument-Read

Sign up for cpt 80306 policy alerts

National Reimbursement Benchmarks

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does CPT 80306 describe and where is it typically performed?

Which CPT codes are commonly reported with or after 80306?

How do national payer reimbursement benchmarks compare for CPT 80306?

Which modifiers are documented as applicable to 80306 and when are they used?

In what clinical workflows and specialties is 80306 commonly used and what is the typical workflow?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does CPT 80306 describe and where is it typically performed?

Which CPT codes are commonly reported with or after 80306?

How do national payer reimbursement benchmarks compare for CPT 80306?

Which modifiers are documented as applicable to 80306 and when are they used?

In what clinical workflows and specialties is 80306 commonly used and what is the typical workflow?

References