CPT code 78454 denotes a cardiac nuclear imaging procedure consisting of multiple planar myocardial perfusion studies to identify areas of deficient blood flow. This imaging modality is used to detect myocardial ischemia and guide clinical decision making for patients with suspected or known coronary artery disease. Nationally, myocardial perfusion imaging remains a widely used noninvasive test for evaluating perfusion abnormalities and informing diagnostic and treatment pathways.

Key payers referenced in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise synthesis of what 78454 represents clinically, typical sites where the service is delivered, and the payer landscape affecting coverage and claims processing. The publication summarizes common modifiers and administrative considerations encountered with this service line and highlights typical billing contexts.

This report is intended to give clinicians, coding staff, and policy analysts a clear, national-level overview of CPT code 78454, its clinical role in cardiac imaging, and the administrative dimensions relevant to reimbursement and documentation. Data not available in the input is noted where applicable.