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    v1.0.30
    OpenPayerBilling CodesDiagnostic Nuclear Medicine Procedures on the Musculoskeletal SystemCPT cpt-78305-bone-scan-scintigraphy-multi-region
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    CPT 78305: Bone Scan (Skeletal Scintigraphy)

    Medicare pays $169 on average nationally for this procedure.

    CPT code 78305 describes a bone scan (scintigraphy) procedure in nuclear medicine in which a radionuclide is injected and imaging is performed to evaluate multiple areas of the skeleton for abnormalities or bone disease; service type: diagnostic nuclear medicine imaging, typical site of service: hospital outpatient imaging center or freestanding nuclear medicine facility.

    For related coverage guidance, see recent payer policy updates: Clinical Review Criteria Intraoperative Neurophysiological Monitoring (IONM), Remote Electrical Neuromodulation for Migraines (i.e., Nerivio®), Lumbar Microdiscectomy.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old male with a history of prostate cancer presents with new-onset bone pain in the pelvis and lower back. The oncologist orders a whole-body bone scintigraphy to evaluate for osseous metastatic disease. The patient arrives at the nuclear medicine suite, consents to the study, and the technologist administers the intravenous radionuclide (commonly technetium-99m-labeled diphosphonate). After an uptake period of approximately 2–3 hours, the patient returns for planar whole-body imaging and spot views of the pelvis and lumbar spine. The interpreting nuclear medicine physician reviews images, compares with prior imaging when available, documents findings (foci of increased radiotracer uptake consistent with metastases versus degenerative change), and issues a formal report. The study is performed in an outpatient hospital radiology department or freestanding nuclear medicine/imaging center, with the typical site of service being an outpatient imaging center, hospital outpatient department, or ambulatory surgical center when appropriate. The service is coded using 78305 for a whole-body bone scan (bone scintigraphy) performed with radionuclide injection and subsequent imaging.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    71020Radiologic examination, chest; single view, frontalChest radiograph often performed when evaluating metastatic disease or prior to certain therapies; may be ordered in the same diagnostic workup.
    78014Skeletal imaging, whole body; planar bone scanAlternative or antecedent code for bone imaging; 78305 is specifically a whole-body bone scintigraphy — 78014 is a related nuclear medicine skeletal procedure sometimes reported for limited views.
    78803Positron emission tomography (PET), single areaPET imaging (e.g., FDG PET/CT or NaF PET/CT) may be performed as a complementary or follow-up modality for equivocal bone scan findings.
    74177CT abdomen and pelvis with contrast, diagnosticCross-sectional imaging often performed to evaluate potential metastatic disease identified on bone scan; used in the same diagnostic pathway.
    88305Surgical pathology, gross and microscopic examinationIf bone lesion is biopsied following abnormal bone scan, pathology services for tissue diagnosis are coded separately.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208M00000X
    207RH0000X
    174400000X
    364S00000X
    2080P0008X
    347B00000X
    2472E0500X
    251X00000X

    Related ICD-10-CM Codes

    23 rows

    ICD-10-CM CodeDescription
    C79.51Secondary malignant neoplasm of bone
    C79.89Secondary malignant neoplasm of other specified sites
    C90.00Multiple myeloma not having achieved remission
    E66.9Obesity, unspecified
    M05.79Rheumatoid arthritis with rheumatoid factor of multiple sites without organ or systems involvement
    M06.9Rheumatoid arthritis, unspecified
    M16.9Osteoarthritis of hip, unspecified
    M17.9Osteoarthritis of knee, unspecified
    M25.50Pain in unspecified joint
    M25.561Pain in right knee

    Showing 1–10 of 23

    Related Payer Policy Updates

    Specialty: Neurology/Neurosurgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Clinical Review Criteria Intraoperative Neurophysiological Monitoring (IONM)Kaiser Permanente2027-01-01
    Remote Electrical Neuromodulation for Migraines (i.e., Nerivio®)bcbsvermont2026-11-01
    Lumbar Microdiscectomyuniverahealthcare2026-10-15
    Artificial Cervical Intervertebral Discuniverahealthcare2026-10-15
    Lumbar Decompressionuniverahealthcare2026-10-15
    Responsive Neurostimulation for Focal EpilepsyPremera Bluecross2026-10-14
    Intraoperative MonitoringProvidence Health Plan2026-10-01
    Intraoperative MonitoringProvidence Health Plan2026-10-01
    High-Intensity Focused UltrasoundMass General Brigham Health Plan2026-10-01
    Vagal Nerve StimulationAmbetter Nevada2026-10-01

    Related Codes

    CPT-78300-BONE-SCAN-LIMITED-AREA-SCINTIGRAPHY

    CPT 78300: Bone Scan (Limited Area Scintigraphy)

    CPT-78306-FULL-BODY-BONE-SCAN-SCINTIGRAPHY

    CPT 78306: Full‑Body Bone Scan (Scintigraphy)

    CPT-78315-THREE-PHASE-BONE-SCAN-SCINTIGRAPHY

    CPT 78315: Three-Phase Bone Scan (Scintigraphy)

    CPT-78350-BONE-MINERAL-DENSITY-SINGLE-PHOTON-ABSORPTIOMETRY

    CPT 78350: Single-Energy Photon Bone Mineral Density Measurement

    CPT-78351-BONE-MINERAL-DENSITY-DUAL-ENERGY-PHOTON-ABSORPTIOMETRY

    CPT 78351: Dual-Energy Photon Bone Mineral Density Measurement

    CPT-78399-MUSCULOSKELETAL-NUCLEAR-MEDICINE-UNLISTED-PROCEDURE

    CPT 78399: Musculoskeletal Diagnostic Nuclear Medicine Procedure (Unlisted)

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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