CPT code 78305 represents a multi-region or whole-body bone scan (scintigraphy), a nuclear medicine procedure that uses injected radionuclide tracer to assess bone metabolism across multiple skeletal sites. Nationally, bone scintigraphy remains important for diagnosing fractures, evaluating suspected metastatic disease, and investigating inflammatory or infectious bone conditions. The code captures the physician or professional service associated with performing and interpreting such studies.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context, typical sites of service, and the practical billing scope of the code. The publication also outlines common modifiers and payer coverage patterns where available, summarizes benchmark considerations, and highlights relevant policy and coding points that affect claim adjudication.

This review is intended to give billing managers, practice leaders, and policy analysts a clear national-level snapshot of CPT code 78305, what it represents clinically, and the areas that most commonly affect coding and reimbursement for bone scintigraphy services.