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    v1.0.30
    OpenPayerBilling CodesRadiation Treatment ManagementCPT cpt-77469-intraoperative-radiation-therapy-iort-during-surgery
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    CPT 77469: Intraoperative Radiation Therapy Management

    Medicare pays $272 on average nationally for this procedure.

    CPT code 77469 describes management of a complete course of intraoperative radiation treatment in which the provider delivers radiation therapy (irradiating X‑rays or electron beams) directly to an exposed tumor during surgery; service type: intraoperative radiation therapy management; typical site of service: operating room or intraoperative surgical suite.

    For related coverage guidance, see recent payer policy updates: Radiation oncology coverage and treatment delivery guidelines, Proton Beam Therapy, Radiation and Oncologic Procedures.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 62-year-old with a localized soft tissue sarcoma of the retroperitoneum or a recurrent breast carcinoma scheduled for tumor resection. After induction of general anesthesia and surgical exposure, the surgical oncologist and radiation oncologist coordinate to deliver a single high-dose intraoperative radiation therapy (IORT) treatment directly to the tumor bed using either electron beam or orthovoltage X‑ray equipment. The radiation oncologist manages the complete intraoperative radiation course, including patient positioning, selection of applicator or cone, dose prescription, shielding of adjacent normal tissues (using lead/shields or packing), real‑time dosimetry checks, and documentation of delivered dose and field. Nursing and anesthesia personnel facilitate sterile access and hemodynamic monitoring. Typical workflow steps: preoperative planning and consent, multidisciplinary time‑out in the operating room, tumor resection or debulking by the surgeon, placement of applicator and shielding, delivery of IORT by the radiation oncology team, confirmation of dose delivery and treatment record completion, removal of applicator and closure of surgical site. Typical site of service is the hospital operating room or an ambulatory surgery center when equipped for sterile IORT delivery. Service type: intraoperative radiation therapy management provided in the OR during a surgical procedure.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    19301Partial mastectomy, lumpectomy — excision of breast lesionCommonly performed immediately before breast IORT to remove tumor and expose tumor bed for intraoperative radiation.
    55866Laparoscopic radical prostatectomy, includes robotic assistanceProstate surgeries may incorporate IORT to deliver targeted dose to tumor bed in select protocols (adjunctive).
    47120Hepatectomy for tumor (wedge resection)Liver tumor resections may be followed by IORT to the resection margin to reduce local recurrence.
    76942Ultrasonic guidance for needle placement (e.g., intraoperative)Used intraoperatively to assist localization or placement of applicators or shields before IORT delivery.
    77334Continuing medical physics consultation, supervision and interpretation for radiotherapy treatment planning, delivery verification and dose monitoringSupports complex radiation planning and dosimetry related to IORT delivery; may be billed in coordination with IORT services when applicable.
    99152Moderate sedation services provided by the same physician performing a diagnostic or therapeutic serviceIn rare cases where moderate sedation is used instead of general anesthesia for an intraoperative procedure in the OR setting; typically anesthesia codes from anesthesia suite are used instead.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    207L00000X
    208000000X
    171M00000X
    204D00000X
    1835X0200X
    2278E0002X
    2279P3900X

    Related Payer Policy Updates

    Specialty: Radiation Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Radiation oncology coverage and treatment delivery guidelinesevicore2026-11-05
    Proton Beam Therapyuniversityofutahhealthplans2026-10-25
    Radiation and Oncologic ProceduresUnitedHealthcare2026-09-01
    Electronic Brachytherapy for Nonmelanoma Skin CancerBluecross Idaho2026-07-30
    Surface Radiation Therapy for Treatment of Non-Melanoma Skin Cancereocco2026-07-09
    Radiofrequency Ablation of Tumors Outside the LiverProvidence Health Plan2026-07-01
    Therapeutic Radiopharmaceuticals in Oncology (Lutathera, Pluvicto, Xofigo) Coverage CriteriaBlue Cross Blue Shield - North Carolina2026-07-01
    Intensity Modulated Radiation TherapyAmbetter Georgia2026-06-01
    Irreversible Electroporation (IRE) of Tumors Other Than LiverBlue Cross Blue Shield - Rhode Island2026-06-01
    Irreversible Electroporation (IRE) — NanoKnife (Preauthorization Required)Blue Cross Blue Shield - Nebraska2026-06-01

    Related Codes

    CPT-77427-RADIATION-THERAPY-MANAGEMENT-EXTERNAL-BEAM

    CPT 77427: Radiation Treatment Management

    CPT-77431-RADIOTHERAPY-MANAGEMENT-ONE-TWO-FRACTION-COURSE

    CPT 77431: Management of Short-Course Fractionated Radiotherapy

    CPT-77432-SINGLE-SESSION-STEREOTACTIC-RADIOSURGERY-PROFESSIONAL

    CPT 77432: Stereotactic Radiosurgery, Single Session (Professional Component)

    CPT-77435-STEREOTACTIC-BODY-RADIOTHERAPY-TREATMENT-MANAGEMENT

    CPT 77435: Stereotactic Body Radiotherapy Course (≤5 Fractions)

    CPT-77437-SUPERFICIAL-RADIATION-THERAPY-PER-FRACTION

    CPT 77437: Superficial Radiation Therapy, Per Fraction

    CPT-77438-ORTHOVOLTAGE-SURFACE-RADIATION-THERAPY-SINGLE-FRACTION

    CPT 77438: Orthovoltage Surface Radiation Therapy, Single Fraction

    CPT-77439-ULTRASOUND-GUIDED-SRT-FIELD-PLACEMENT

    CPT 77439: Ultrasound-Guided SRT Field Localization for Cutaneous Tumors

    CPT-77470-SPECIAL-RADIOTHERAPY-MANAGEMENT

    CPT 77470: Special Radiotherapy Procedures Requiring Additional Management

    CPT-77499-UNLISTED-THERAPEUTIC-RADIOLOGY-TREATMENT-MANAGEMENT

    CPT 77499: Therapeutic Radiology Treatment Management, Unlisted

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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