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    v1.0.30
    OpenPayerBilling CodesStereotactic Radiation Treatment DeliveryCPT cpt-77387-image-guidance-radiation-therapy-targeting
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    CPT 77387: Image Guidance for Radiation Target Localization

    Medicare pays $37 on average nationally for this procedure.

    CPT code 77387 describes imaging guidance used to locate the radiation target site for delivery of therapeutic radiation to a tumor, enabling precise targeting of the lesion while protecting surrounding healthy tissues; service type: image-guided radiation therapy localization; typical site of service: radiation oncology department or hospital outpatient radiation therapy suite.

    For related coverage guidance, see recent payer policy updates: Radiation oncology coverage and treatment delivery guidelines, Proton Beam Therapy, Radiation and Oncologic Procedures.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 65-year-old with a confirmed localized prostate adenocarcinoma scheduled for external beam radiation therapy. On simulation day the radiation oncologist and medical physicist perform CT-based treatment planning. During each treatment fraction the provider uses imaging guidance to localize the target and verify patient position before delivery of therapeutic radiation. Imaging modalities commonly used include on-board cone beam CT or orthogonal kV imaging to align the patient and internal markers, protecting surrounding healthy tissues such as bladder and rectum. The clinical workflow: initial consultation and staging imaging → CT simulation with immobilization and fiducial marker placement if needed → treatment planning and dose calculation → daily image-guided localization using 77387 prior to fraction delivery → periodic on-treatment assessments and follow-up after course completion.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    77300Basic radiation dosimetry calculation and treatment device design; part of radiation planningPerformed earlier in the workflow to calculate dose and design the treatment plan before image-guided localization
    77295Therapeutic radiology simulation-aided field setting; complexPerformed at simulation to localize target anatomy and create reproducible setup used by 77387 during daily guidance
    50542Insertion of prostate fiducial markers, percutaneous, radiologicFiducial placement may precede 77387 image-guided localization when internal markers are used
    77427Radiation treatment management, complex, weekly managementUsed for on-treatment management visits that accompany serial imaging and localization during the radiation course
    77334Continuing medical physics consultation, review of patient treatment records and special proceduresMedical physics services that support imaging guidance accuracy and treatment delivery quality assurance

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    95Modifier 95 indicates that a service was provided via synchronous, real‑time audio‑video telehealth rather than in‑person. Per CMS, AAPC and professional associations, append modifier 95 to claim…- Use modifier 95 to indicate a service was furnished via synchronous, real‑time audiovisual telehealth (a live audio‑video conference between patient and provider) rather than in‑person. - Pair…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208100000X
    208D00000X
    363L00000X
    207SG0203X
    2080S0012X
    229N00000X
    152WP0200X
    163WX0800X

    Related Payer Policy Updates

    Specialty: Radiation Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Radiation oncology coverage and treatment delivery guidelinesevicore2026-11-05
    Proton Beam Therapyuniversityofutahhealthplans2026-10-25
    Radiation and Oncologic ProceduresUnitedHealthcare2026-09-01
    Electronic Brachytherapy for Nonmelanoma Skin CancerBluecross Idaho2026-07-30
    Surface Radiation Therapy for Treatment of Non-Melanoma Skin Cancereocco2026-07-09
    Radiofrequency Ablation of Tumors Outside the LiverProvidence Health Plan2026-07-01
    Therapeutic Radiopharmaceuticals in Oncology (Lutathera, Pluvicto, Xofigo) Coverage CriteriaBlue Cross Blue Shield - North Carolina2026-07-01
    Intensity Modulated Radiation TherapyAmbetter Georgia2026-06-01
    Irreversible Electroporation (IRE) of Tumors Other Than LiverBlue Cross Blue Shield - Rhode Island2026-06-01
    Irreversible Electroporation (IRE) — NanoKnife (Preauthorization Required)Blue Cross Blue Shield - Nebraska2026-06-01

    Related Codes

    CPT-77371-STEREOTACTIC-RADIOSURGERY-TECHNICAL-COBALT-60

    CPT 77371: Stereotactic Radiosurgery Technical Component

    CPT-77372-STEREOTACTIC-RADIOSURGERY-TECHNICAL-COMPONENT

    CPT 77372: Stereotactic Radiosurgery, Technical Component

    CPT-77373-STEREOTACTIC-BODY-RADIATION-THERAPY-TECHNICAL-SINGLE-FRACTION

    CPT 77373: Stereotactic Body Radiation Therapy, Technical Component

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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