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    v1.0.28
    OpenPayerBilling CodesExcision and Implantation Procedures on the Somatic NervesCPT cpt-64795-nerve-biopsy-nerve-sample-excision
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    CPT 64795: Nerve Biopsy (Excision of Small Nerve Segment)

    Medicare pays $188 on average nationally for this procedure.

    CPT code 64795 describes surgical excision of a small segment of nerve (nerve biopsy) for laboratory examination to evaluate nerve damage, degeneration, or inflammatory neuropathies; service type: surgical diagnostic procedure; typical site of service: outpatient surgical suite, hospital operating room, or ambulatory surgery center for collection and tissue processing.

    For related coverage guidance, see recent payer policy updates: Artificial Cervical Intervertebral Disc, Lumbar Microdiscectomy, Lumbar Decompression.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 45-year-old adult referred to a peripheral nerve surgeon or neurosurgeon for progressive numbness, paresthesia, and focal weakness in a limb after trauma or with suspected neuropathy. Prior evaluation includes a history and physical, electromyography/nerve conduction studies showing abnormalities, and imaging when indicated. The provider obtains informed consent for surgical nerve biopsy to obtain a small segment of a peripheral sensory nerve (commonly sural nerve) for histopathology, special stains, and possible immunohistochemistry to evaluate for demyelination, axonal degeneration, vasculitis, amyloid, or inflammatory neuropathies.

    The clinical workflow: preoperative assessment and optimization, marking the biopsy site (often sural nerve in the posterior-lateral calf for sensory testing), administration of local or general anesthesia, aseptic exposure of the nerve, excision of the required small segment with preservation of proximal and distal continuity where possible, hemostasis, specimen labeling and submission to pathology with relevant clinical history, closure of the incision, and postoperative follow-up for wound care and review of pathology results that inform diagnosis and further medical management.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    29807Arthroscopy, shoulder, diagnostic, with synovial biopsyNot directly related anatomically but represents minimally invasive biopsy techniques; included when concomitant joint evaluation is needed.
    20220Biopsy of soft tissue of neck; open, superficialRelevant as another open soft tissue biopsy code when concurrent regional soft tissue biopsies are performed.
    36415Collection of venous blood by venipunctureOften performed preoperatively for blood tests and sent with biopsy specimen workup (serologies, labs).
    88305Level IV surgical pathology, gross and microscopic examinationCommon pathology CPT for processing and interpreting a nerve biopsy specimen; billed by pathology.
    95004Percutaneous test, cutaneous, scratch, or puncture (allergen)Not commonly used with nerve biopsy; listed only if differential diagnostic testing for allergy-related neuropathies is performed.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    207RH0000XHematology (Internal Medicine) PhysicianAn internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    364SI0800XInformatics Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    207ZH0000XHematology (Pathology) PhysicianA hematopathologist is expert in diseases that affect blood cells, blood clotting mechanisms, bone marrow and lymph nodes. This physician has the know…
    374700000XTechnician(1) A person with specialized training in a narrow field of expertise whose occupation requires training and is skilled in specific technical processe…
    103T00000XPsychologistA psychologist is an individual who is licensed to practice psychology which is defined as the observation, description, evaluation, interpretation, a…

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    B58.9Toxoplasmosis, unspecified
    E10.42Type 1 diabetes mellitus with diabetic polyneuropathy
    E11.42Type 2 diabetes mellitus with diabetic polyneuropathy
    G54.0Brachial plexus disorders
    G54.1Lumbosacral plexus disorders
    G54.3Thoracic root disorders, not elsewhere classified
    G56.00Carpal tunnel syndrome, unspecified upper limb
    G56.01Carpal tunnel syndrome, right upper limb
    G56.02Carpal tunnel syndrome, left upper limb
    G57.00Lesion of sciatic nerve, unspecified lower limb

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Neurology/Neurosurgery1 / 3

    7 rows

    PolicyPayerEffective Date
    Artificial Cervical Intervertebral Discuniverahealthcare2026-10-15
    Lumbar Microdiscectomyuniverahealthcare2026-10-15
    Lumbar Decompressionuniverahealthcare2026-10-15
    Nerve Fiber Density Testing (IENFD/ENFD) Coverage CriteriaOscar Health2026-10-01
    Biomarker Testing for Multiple Sclerosis and Related Neurologic DiseasesOscar Health2026-10-01
    Biochemical Markers of Alzheimer Disease and DementiaOscar Health2026-10-01
    Serum Testing For Evidence of Mild Traumatic Brain InjuryOscar Health2026-10-01

    Related Codes

    CPT-64774-NERVE-TUMOR-EXCISION-PERIPHERAL-NERVE

    CPT 64774: Excision of Tumor From Peripheral Nerve

    CPT-64776-DIGITAL-NERVE-TUMOR-EXCISION-FINGER-TOE

    CPT 64776: Excision of Tumor on Digital Nerve

    CPT-64778-PERIPHERAL-NERVE-TUMOR-EXCISION-ADDITIONAL-DIGIT

    CPT 64778: Excision of Peripheral Nerve Tumor in Finger or Toe

    CPT-64782-PERIPHERAL-NERVE-TUMOR-EXCISION-HAND-FOOT

    CPT 64782: Excision of Neuroma on Peripheral Nerve of Hand or Foot

    CPT-64783-PERIPHERAL-NERVE-NEUROMA-EXCISION-HAND-FOOT-ADDITIONAL

    CPT 64783: Excision of Additional Peripheral Nerve Neuroma, Hand or Foot

    CPT-64784-PERIPHERAL-NERVE-TUMOR-EXCISION

    CPT 64784: Peripheral Nerve Tumor Excision

    CPT-64786-SCIATIC-NERVE-TUMOR-EXCISION

    CPT 64786: Excision of Sciatic Nerve Neuroma

    CPT-64787-NERVE-END-IMPLANTATION-AFTER-NEUROMA-EXCISION

    CPT 64787: Implantation of Transected Nerve End into Bone or Muscle

    CPT-64788-EXCISION-SUBCUTANEOUS-TUMOR-CUTANEOUS-NERVE

    CPT 64788: Excision of Tumor Along Cutaneous Nerve

    CPT-64790-PERIPHERAL-NERVE-SHEATH-TUMOR-EXCISION

    CPT 64790: Excision of Tumor of Major Peripheral Nerve

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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