CPT code 64680 denotes a celiac plexus neurolytic injection — an interventional pain management procedure that destroys the celiac plexus with a neurodestructive agent to reduce severe chronic abdominal pain from causes such as abdominal malignancy or chronic pancreatitis. This procedure can be performed with image guidance and is typically delivered in ambulatory surgical centers, hospital outpatient departments, or specialized interventional pain clinics. Nationally, 64680 matters because it is a specialized, clinically-driven service often associated with high-acuity pain management and oncology support care.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context and service settings, common payer coverage considerations, and the types of benchmarks and policy topics typically relevant to this code (coverage criteria, site-of-service implications, and utilization patterns). The publication summarizes common modifiers and administrative details provided in the input and identifies gaps where data were not supplied. The aim is to equip billing, clinical, and payer audiences with a clear, nationally-focused reference for CPT code 64680 to support coding, claims review, and policy discussions.