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CPT 64653: Chemical Injection to Eccrine Glands for Non‑Axillary Hyperhidrosis
CPT code 64653 identifies a procedure in which a chemical compound is injected into eccrine sweat glands outside the axillae to treat hyperhidrosis. This targeted, outpatient procedure addresses focal excessive sweating in regions such as palms, soles, or craniofacial areas and is relevant to dermatology, plastic surgery, and outpatient procedural practices. Nationally, the code matters because it captures a non-surgical, focal treatment option for a common and quality-of-life–affecting condition and is used to track utilization, coverage decisions, and payment policy for non-axillary hyperhidrosis therapies.
Key payers discussed in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an overview of clinical context for the procedure, payer coverage themes, common billing modifiers, and benchmarks where available. The publication also outlines coding considerations, typical sites of service, and policy or coverage trends that may influence access to this non-axillary hyperhidrosis treatment. Data not available in the input is noted where applicable.
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Billing Code Overview
CPT code 64653 describes injection of a chemical compound into eccrine glands in areas other than the axillae to treat hyperhidrosis (excessive sweating). The procedure targets sweat-producing glands with localized chemical treatment to reduce sweating in affected non-axillary regions.
Service type: Procedure — chemical injection for hyperhidrosis treatment
Typical site of service: Outpatient clinic or ambulatory procedure setting