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    v1.0.30
    OpenPayerBilling CodesDestruction by Neurolytic Agent (eg, Chemical, Thermal, Electrical or Radiofrequency) Procedures on the Somatic NervesCPT cpt-64640-neurolysis-nerve-destruction-pain-management
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    CPT 64640: Neurolysis (Chemical, Heat, or Radiofrequency)

    Medicare pays $278 on average nationally for this procedure.

    CPT code 64640 describes neurolysis, the destruction of pain-transmitting nerves using chemical, heat, or radiofrequency methods; this is a pain management procedure typically performed as an interventional radiology or pain clinic service and commonly delivered in an outpatient procedure suite or ambulatory surgical center where targeted nerve ablation is performed under imaging or needle guidance.

    For related coverage guidance, see recent payer policy updates: Dental Anesthesia Services, Anesthesia Services for Interventional Pain Management Procedures in an Adult, General Anesthesia and Conscious Sedation Services.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 58-year-old with chronic lumbar radicular pain refractory to conservative measures including physical therapy, oral analgesics, and epidural steroid injections. The patient reports persistent shooting pain in the right lower extremity corresponding to the S1 dermatome and has had functional impairment for >6 months. Imaging shows degenerative disc disease with foraminal stenosis and correlates with exam and symptom distribution. After multidisciplinary evaluation, the pain management specialist recommends percutaneous radiofrequency neurolysis (thermodegeneration of targeted dorsal root ganglion or medial branch nerves) to disrupt pain transmission.

    Clinical workflow: the patient undergoes pre-procedure evaluation including informed consent, medication reconciliation (anticoagulation management), and review of prior imaging. On procedure day in an ambulatory surgery center or hospital outpatient department, monitored anesthesia care or local anesthesia with sedation is provided. Fluoroscopic or CT guidance is used to localize the target nerve(s). Neurolytic technique is performed using radiofrequency ablation or chemical neurolysis per protocol. Post-procedure monitoring occurs in recovery with discharge instructions and follow-up arranged with the pain clinic for outcome assessment and potential additional interventions.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    20552Injection(s); single or multiple trigger point(s), 1 or 2 muscle(s)May be performed prior to or instead of neurolysis for myofascial contributors to pain.
    64483Injection(s), anesthetic agent; other peripheral branch of trigeminal nerveExample of a peripheral nerve block that can be diagnostic prior to neurolysis when applicable.
    77002Fluoroscopic guidance for needle placement (radiological supervision and interpretation)Imaging guidance often billed alongside neurolysis when fluoroscopy is used for needle placement.
    76942Ultrasonic guidance for needle placementUltrasound guidance alternative for localization during percutaneous neurolytic procedures.
    99152Moderate sedation services provided by the same physician performing the procedure (initial 15 minutes)Sedation services commonly provided during neurolytic procedures; bill per payer rules.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2084P0800X
    207L00000X
    208D00000X
    2085R0205X
    292200000X
    207RM1200X
    2085U0001X
    2471V0105X

    Related ICD-10-CM Codes

    23 rows

    ICD-10-CM CodeDescription
    B02.22Postherpetic trigeminal neuralgia
    B02.23Postherpetic polyneuropathy
    G50.0Trigeminal neuralgia
    G50.1Atypical facial pain
    G60.3Idiopathic progressive neuropathy
    G62.9Polyneuropathy, unspecified
    G89.0Central pain syndrome
    G89.29Other chronic pain
    G89.3Neoplasm related pain (acute) (chronic)
    G89.4Chronic pain syndrome

    Showing 1–10 of 23

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Dental Anesthesia ServicesProvidence Health Plan2026-10-01
    Anesthesia Services for Interventional Pain Management Procedures in an AdultCigna2026-09-15
    General Anesthesia and Conscious Sedation ServicesUnitedHealthcare2026-09-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21

    Related Codes

    CPT-64600-TRIGEMINAL-NERVE-NEURODESTRUCTIVE-INJECTION

    CPT 64600: Trigeminal Nerve Neurodestruction by Injection

    CPT-64605-TRIGEMINAL-NERVE-NEURODESTRUCTIVE-INJECTION

    CPT 64605: Trigeminal Nerve Neurodestructive Injection

    CPT-64610-TRIGEMINAL-NERVE-NEURODESTRUCTIVE-INJECTION

    CPT 64610: Trigeminal Nerve Neurodestructive Injection

    CPT-64611-SALIVARY-GLAND-CHEMICAL-DENERVATION-BILATERAL

    CPT 64611: Bilateral Salivary Gland Chemical Injection for Sialorrhea

    CPT-64612-FACIAL-NERVE-CHEMICAL-NEUROLYSIS-UNILATERAL

    CPT 64612: Facial Nerve Chemical Neurolysis, Unilateral

    CPT-64615-BILATERAL-CHEMICAL-DENERVATION-FACIAL-CERVICAL-MUSCLES

    CPT 64615: Bilateral Chemical Denervation of Head and Neck Muscles

    CPT-64616-UNILATERAL-CERVICAL-MUSCLE-CHEMICAL-DENERVATION

    CPT 64616: Unilateral Neck Muscle Chemodenervation

    CPT-64617-PERCUTANEOUS-LARYNGEAL-CHEMODENERVATION-UNILATERAL

    CPT 64617: Percutaneous Chemodenervation of Larynx, Unilateral

    CPT-64620-INTERCOSTAL-NERVE-ABLATION

    CPT 64620: Intercostal Nerve Destruction (Chemical/Heat/Radiofrequency)

    CPT-64624-GENICULAR-NERVE-NEUROLYSIS-KNEE

    CPT 64624: Genicular Nerve Neurolysis for Knee Pain

    Showing 1–10 of 26

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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