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    v1.0.28
    OpenPayerBilling CodesCraniectomy or Craniotomy ProceduresCPT cpt-61548-pituitary-tumor-resection-transnasal-transoral
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    CPT 61548: Transnasal/Transoral Resection of Pituitary Tumor, No Imaging Guidance

    Medicare pays $1491 and commercial payers pay $1951 on average nationally for this procedure.

    CPT code 61548 describes surgical resection of part of the pituitary gland or excision of a pituitary tumor performed via a transnasal or transoral approach without the use of imaging guidance; service type: surgical resection of pituitary lesion; typical site of service: operating room or ambulatory surgical center under general anesthesia for neurosurgical procedures.

    For related coverage guidance, see recent payer policy updates: Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders, Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders, Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders.

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    National Reimbursement Benchmarks

    Medicare’s mean rate of $1490.8 sits below BUCA’s average commercial mean of $1950.8, indicating that commercial arrangements through BUCA pay substantially more on average than Medicare for CPT 61548. The gap of $460.0 between the two means highlights a meaningful commercial premium versus the federal program.

    Dispersion (P75 minus P25) varies notably: Blue Cross Blue Shield shows a tight range of $1125.6 (P75 $2244.7 minus P25 $1119.1), while UnitedHealth Group and Cigna exhibit the widest spreads at $1714.9 (UnitedHealth Group P75 $3498.3 minus P25 $1783.4) and $1684.0 (Cigna P75 $3249.2 minus P25 $1564.2), respectively. BUCA’s interquartile spread is $1345.3, placing it between the tightest and widest payers.

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    National Payer Mean Reimbursement Rates

    State Reimbursement Rates

    State: Alaska1 / 51

    Rate by payer

    Clinical & Coding Specifications

    Clinical Context

    A 48-year-old patient presents with progressive headaches, visual field defects and endocrine abnormalities. MRI demonstrates a pituitary macroadenoma causing optic chiasm compression and progressive visual loss; pathology evaluation is consistent with a nonfunctioning pituitary tumor. The neurosurgeon schedules a transnasal transsphenoidal resection without use of intraoperative imaging guidance. The clinical workflow includes preoperative endocrine and ophthalmologic evaluation, informed consent, anesthesia evaluation, endoscopic transnasal approach to the sella, resection of tumor tissue with hemostasis, specimen submission for pathology, intraoperative reconstruction of the skull base if needed, postoperative monitoring in recovery or ICU for neurologic and endocrine status, and short-term follow-up with pituitary endocrinology and neuro-ophthalmology for surveillance and replacement therapy as indicated.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    61781Stereotactic computer-assisted procedure; intraoperative navigationMay be used when image-guided stereotactic assistance is employed instead of blind transnasal resection; alternative or adjunct in complex cases.
    61210Burr hole for biopsy, or for access to deep intracranial lesion

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207T00000XNeurological Surgery PhysicianA neurological surgeon provides the operative and non-operative management (i.e., prevention, diagnosis, evaluation, treatment, critical care, and reh…
    208600000XSurgery PhysicianA general surgeon has expertise related to the diagnosis - preoperative, operative and postoperative management - and management of complications of s…
    207ZP0102XAnatomic Pathology & Clinical Pathology PhysicianA pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis and treatment through knowledge gained by the labora…
    261QM2800XMethadone ClinicAn entity, facility, or distinct part of a facility providing diagnostic, and replacement maintenance treatment services related to individuals with d…
    282NW0100XWomen's HospitalHospitals · General Acute Care Hospital
    227800000XCertified Respiratory TherapistA Certified Respiratory Therapist (CRT) is a an entry level therapist who has passed a standardized written examination administered by the National B…
    302R00000XHealth Maintenance Organization(1) A form of health insurance in which its members prepay a premium for the HMO's health services which generally include inpatient and ambulatory ca…
    261QC1500XCommunity Health Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    9 rows

    PolicyPayerEffective Date
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21
    Mm_0579_Coveragepositioncriteria_Anesthesia_Services_Selected_Nerve_BlocksCigna2026-05-15
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric DisordersBlue Cross Blue Shield - North Carolina2026-04-01

    Related Codes

    CPT-61304-ANTERIOR-SKULL-CRANIOTOMY-BRAIN-INSPECTION

    CPT 61304: Supratentorial Craniotomy for Frontal Brain Inspection

    CPT-61305-POSTERIOR-FOSSA-INSPECTION-SUBTENTORIAL-APPROACH

    CPT 61305: Posterior Fossa Cranial Exploration

    CPT-61312-SUPRATENTORIAL-HEMATOMA-EVACUATION-CRANIOTOMY

    CPT 61312: Supratentorial Hematoma Evacuation, Craniotomy/Craniectomy

    CPT-61313-FRONTAL-HEMATOMA-EVACUATION-BURR-HOLE-CRANIOTOMY

    CPT 61313: Craniotomy/Burr Hole Evacuation of Intracranial Hematoma

    CPT-61314-NEUROSURGICAL-HEMATOMA-EVACUATION-BURR-HOLES

    CPT 61314: Evacuation of Subdural Hematoma via Burr Holes or Craniotomy

    CPT-61315-POSTERIOR-FOSSA-CRANIOTOMY-HEMATOMA-EVACUATION

    CPT 61315: Suboccipital Craniotomy for Cerebellar Hematoma Drainage

    CPT-61316-CRANIAL-BONE-GRAFT-POCKETING-TEMPORARY-ABDOMINAL-STORAGE

    CPT 61316: Temporary Subcutaneous Cranial Bone Graft Placement

    CPT-61320-INTRACRANIAL-ABSCESS-DRAINAGE-SUPRATENTORIAL

    CPT 61320: Craniotomy for Drainage of Intracranial Abscess

    CPT-61321-CRANIAL-ABSCESS-DRAINAGE

    CPT 61321: Craniotomy to Drain Brain Abscess

    CPT-61322-DECOMPRESSIVE-CRANIECTOMY-DURAPLASTY

    CPT 61322: Decompressive Craniectomy for Elevated Intracranial Pressure

    Showing 1–10 of 62

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    May be used when an open cranial approach or stereotactic biopsy is performed instead of transsphenoidal resection.
    61304Craniectomy or craniotomy for evacuation of hematomaRelevant for management of intracranial hemorrhagic complications that could occur and require separate surgical evacuation.
    61607Resection of arteriovenous malformation, intracranialListed as a related intracranial resection code; represents other complex intracranial resections performed by the same surgical specialties.