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    v1.0.28
    OpenPayerBilling CodesCraniectomy or Craniotomy ProceduresCPT cpt-61541-corpus-callosotomy-craniotomy
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    CPT 61541: Partial Corpus Callosotomy with Craniotomy

    Medicare pays $2087 on average nationally for this procedure.

    CPT code 61541 describes a neurosurgical procedure in which the surgeon elevates a portion of the skull (craniotomy) and severs nerve fibers of the corpus callosum to disconnect the right and left cerebral hemispheres; service type: neurosurgical open cranial procedure; typical site of service: hospital operating room.

    For related coverage guidance, see recent payer policy updates: Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders, Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders, Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with medically refractory epilepsy characterized by frequent, disabling generalized tonic-clonic or drop seizures despite optimized antiepileptic drug therapy and consideration of less invasive options. The patient has undergone comprehensive evaluation including video-EEG monitoring, neuroimaging (MRI brain), neuropsychological testing, and multidisciplinary epilepsy conference review. Imaging excludes a resectable focal epileptogenic lesion, or prior focal resection failed to control generalized seizure spread. The surgical plan is for a partial or complete corpus callosotomy performed under general anesthesia with a craniotomy or craniectomy (elevation of a portion of skull bone) to interrupt interhemispheric spread of epileptic discharges. Intraoperative neurophysiologic monitoring (electrocorticography and motor/sensory evoked potentials) is commonly used to guide the extent of callosal sectioning and minimize functional deficits. Postoperative care includes ICU monitoring for airway and hemodynamic stability, serial neurologic examinations, postoperative imaging (CT or MRI) to evaluate surgical changes and complications, adjustment of antiseizure medications, and rehabilitation services as needed for gait or cognitive changes. Typical sites of service are an inpatient operating room with subsequent inpatient stay for observation and recovery.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    61541Craniotomy for corpus callosotomy; open, partial or complete (elevation of skull bone and sectioning of corpus callosum)Primary procedure for severing interhemispheric connections to reduce seizure generalization.
    95886Monitoring for central nervous system intraoperative neurophysiology, evoked potentials and neurophysiologic monitoring during surgery; more than one modality recorded, interpreted and documented separatelyCommonly performed concurrently to monitor interhemispheric function and detect impending neurologic injury.
    61618Stereotactic guidance for lesion localization and neuroendoscopy (when used)May be used if stereotactic navigation assists accurate midline approach or lesion localization.
    99153Moderate sedation services provided by an independent sedation practitioner (initial 15 minutes) — intraoperative or postoperative sedation services when applicableUsed if a dedicated sedation practitioner provides monitored anesthesia care for portions of the procedure or immediate postoperative imaging in selected workflows.
    70551MRI brain without contrastPreoperative or postoperative imaging to evaluate anatomy and extent of callosal section and to exclude complications.
    70450CT head without contrastImmediate postoperative imaging in the recovery period to evaluate for hemorrhage or bony changes after skull elevation.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    2084N0400XNeurology PhysicianA Neurologist specializes in the diagnosis and treatment of diseases or impaired function of the brain, spinal cord, peripheral nerves, muscles, auton…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    261QP2000XPhysical Therapy Clinic/CenterAn entity, facility, or distinct part of a facility providing diagnostic and treatment services related to physical rehabilitation. Physical therapy i…
    163WN0300XNephrology Registered NurseNursing Service Providers · Registered Nurse
    207ZD0900XDermatopathology (Pathology) PhysicianA dermatopathologist is an expert in diagnosing and monitoring diseases of the skin including infectious, immunologic, degenerative, and neoplastic di…
    207UN0903XIn Vivo & In Vitro Nuclear Medicine PhysicianA nuclear medicine physician who specializes in in vivo and in vitro nuclear medicine.
    2086S0120XPediatric Surgery PhysicianA surgeon with expertise in the management of surgical conditions in premature and newborn infants, children and adolescents.

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    9 rows

    PolicyPayerEffective Date
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21
    Mm_0579_Coveragepositioncriteria_Anesthesia_Services_Selected_Nerve_BlocksCigna2026-05-15
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric DisordersBlue Cross Blue Shield - North Carolina2026-04-01

    Related Codes

    CPT-61304-ANTERIOR-SKULL-CRANIOTOMY-BRAIN-INSPECTION

    CPT 61304: Supratentorial Craniotomy for Frontal Brain Inspection

    CPT-61305-POSTERIOR-FOSSA-INSPECTION-SUBTENTORIAL-APPROACH

    CPT 61305: Posterior Fossa Cranial Exploration

    CPT-61312-SUPRATENTORIAL-HEMATOMA-EVACUATION-CRANIOTOMY

    CPT 61312: Supratentorial Hematoma Evacuation, Craniotomy/Craniectomy

    CPT-61313-FRONTAL-HEMATOMA-EVACUATION-BURR-HOLE-CRANIOTOMY

    CPT 61313: Craniotomy/Burr Hole Evacuation of Intracranial Hematoma

    CPT-61314-NEUROSURGICAL-HEMATOMA-EVACUATION-BURR-HOLES

    CPT 61314: Evacuation of Subdural Hematoma via Burr Holes or Craniotomy

    CPT-61315-POSTERIOR-FOSSA-CRANIOTOMY-HEMATOMA-EVACUATION

    CPT 61315: Suboccipital Craniotomy for Cerebellar Hematoma Drainage

    CPT-61316-CRANIAL-BONE-GRAFT-POCKETING-TEMPORARY-ABDOMINAL-STORAGE

    CPT 61316: Temporary Subcutaneous Cranial Bone Graft Placement

    CPT-61320-INTRACRANIAL-ABSCESS-DRAINAGE-SUPRATENTORIAL

    CPT 61320: Craniotomy for Drainage of Intracranial Abscess

    CPT-61321-CRANIAL-ABSCESS-DRAINAGE

    CPT 61321: Craniotomy to Drain Brain Abscess

    CPT-61322-DECOMPRESSIVE-CRANIECTOMY-DURAPLASTY

    CPT 61322: Decompressive Craniectomy for Elevated Intracranial Pressure

    Showing 1–10 of 62

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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