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    v1.0.30
    OpenPayerBilling CodesIncision Procedures on the ProstateCPT cpt-55705-prostate-biopsy-non-image-guided
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    CPT 55705: Prostate Tissue Sampling, Non‑Imaging Guided

    Medicare pays $242 on average nationally for this procedure.

    CPT code 55705 describes a clinician-performed prostate tissue sampling procedure without imaging guidance intended to obtain specimens for cancer or other disease evaluation; service type: percutaneous or transperineal/transrectal prostate biopsy (non–image-guided); typical site of service: outpatient clinic, physician office, or ambulatory surgical center where tissue collection is performed without imaging assistance.

    For related coverage guidance, see recent payer policy updates: Dental Anesthesia Services, Anesthesia Services for Interventional Pain Management Procedures in an Adult, General Anesthesia and Conscious Sedation Services.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 63-year-old male presents to the urology clinic with an elevated prostate-specific antigen (PSA) level of 8.2 ng/mL and a suspicious digital rectal exam finding of a firm nodule in the peripheral zone of the prostate. After informed consent and pre-procedure assessment, the urologist performs a transrectal, non-image-guided prostate needle biopsy to obtain multiple tissue cores for histopathologic evaluation for prostate cancer. The procedure is often performed in an ambulatory surgical center or hospital outpatient department under local anesthesia with or without sedation. Typical workflow: pre-procedure verification and consent, topical or local anesthesia, perineal or transrectal approach to obtain systematic biopsy cores, specimen labeling and submission to pathology, post-procedure observation for bleeding or urinary retention, and discharge with post-biopsy instructions and follow-up for pathology results.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    55700Biopsy, prostate; needle or punch, single or multiple, any approachClosely related code for prostate biopsy when coding specifics differ; used when documentation aligns with this code rather than 55705
    88305Pathology, surgical pathology, gross and microscopic examination, level IV (commonly used for prostate biopsy specimens)Used by pathology to report evaluation of multiple prostate biopsy cores
    76942Ultrasonic guidance for needle placement (eg, biopsy, aspiration, or localization device)Used when imaging guidance is employed; not reported with 55705 which is non-image-guided
    52204Cystourethroscopy, with biopsy (separate procedure)May be performed if concurrent bladder or urethral pathology is being evaluated
    J1050Injection, lidocaine (example supply/drug HCPCS)Associated supplies/medication billing for local anesthesia during the biopsy

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    208600000X
    207R00000X
    207L00000X
    363L00000X
    1223P0300X
    320900000X
    225XE1200X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    C61Malignant neoplasm of prostate
    D07.4Carcinoma in situ of penis
    D07.5Carcinoma in situ of prostate
    D29.1Benign neoplasm of prostate
    N40.0Benign prostatic hyperplasia without lower urinary tract symptoms
    N40.1Benign prostatic hyperplasia with lower urinary tract symptoms
    N40.2Nodular prostate without lower urinary tract symptoms
    N40.3Nodular prostate with lower urinary tract symptoms
    N41.0Acute prostatitis
    N41.1Chronic prostatitis

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Dental Anesthesia ServicesProvidence Health Plan2026-10-01
    Anesthesia Services for Interventional Pain Management Procedures in an AdultCigna2026-09-15
    General Anesthesia and Conscious Sedation ServicesUnitedHealthcare2026-09-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21

    Related Codes

    CPT-55706-TEMPLATE-GUIDED-TRANSPERINEAL-PROSTATE-SATURATION-BIOPSY

    CPT 55706: Template-Guided Saturation Biopsy of Prostate

    CPT-55707-TRANSRECTAL-ULTRASOUND-GUIDED-PROSTATE-BIOPSY-SEXTANT

    CPT 55707: Transrectal Ultrasound-Guided Prostate Biopsy, Sextant and Targeted

    CPT-55708-PROSTATE-BIOPSY-TRANSRECTAL-US-FUSION-TARGETED-SEXTANT

    CPT 55708: Transrectal Ultrasound–Guided Prostate Biopsy with MRI Fusion

    CPT-55709-TRANSPERINEAL-ULTRASOUND-GUIDED-PROSTATE-BIOPSY

    CPT 55709: Perineal Ultrasound-Guided Prostate Biopsy

    CPT-55710-TRANSPERINEAL-ULTRASOUND-FUSION-PROSTATE-BIOPSY

    CPT 55710: Transperineal Ultrasound‑Guided Sextant and Fusion Prostate Biopsy

    CPT-55711-MRI-ULTRASOUND-FUSION-TARGETED-PROSTATE-BIOPSY-FIRST-LESION

    CPT 55711: Transrectal MRI–Ultrasound Fusion Targeted Prostate Biopsy, First Lesion

    CPT-55712-TRANSPERINEAL-MRI-ULTRASOUND-FUSION-BIOPSY-SINGLE-LESION

    CPT 55712: Transperineal MRI–Ultrasound Fusion Targeted Prostate Biopsy, First Lesion

    CPT-55713-IMAGE-GUIDED-PROSTATE-BIOPSY-SEXTANT-AND-TARGETED-LESION

    CPT 55713: Image-Guided Prostate Biopsy, Sextant and Targeted Sampling

    CPT-55714-IMAGE-GUIDED-TARGETED-PROSTATE-BIOPSY-CT-MRI

    CPT 55714: CT or MRI-Guided Targeted Prostate Biopsy

    CPT-55715-TARGETED-PROSTATE-BIOPSY-ADDITIONAL-LESION

    CPT 55715: Additional Targeted Prostate Lesion Biopsy

    Showing 1–10 of 12

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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